ENSG00000111731

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000333957 ENSG00000111731 HEK293_OSMI2_6hA HEK293_TMG_6hB C2CD5 protein_coding protein_coding 10.86901 3.614652 19.47391 0.3524476 0.9152598 2.426369 6.8182602 2.29617193 13.144061 0.33937873 1.0755160 2.511936 0.63432917 0.6290667 0.67276667 0.04370000 8.608659e-01 1.891092e-10 FALSE TRUE
ENST00000446597 ENSG00000111731 HEK293_OSMI2_6hA HEK293_TMG_6hB C2CD5 protein_coding protein_coding 10.86901 3.614652 19.47391 0.3524476 0.9152598 2.426369 0.5322307 0.49562226 0.000000 0.13837956 0.0000000 -5.659988 0.07981667 0.1330000 0.00000000 -0.13300000 1.891092e-10 1.891092e-10 FALSE TRUE
ENST00000542676 ENSG00000111731 HEK293_OSMI2_6hA HEK293_TMG_6hB C2CD5 protein_coding protein_coding 10.86901 3.614652 19.47391 0.3524476 0.9152598 2.426369 0.9169307 0.00000000 2.466610 0.00000000 0.2140130 7.952223 0.05073333 0.0000000 0.12720000 0.12720000 8.850712e-09 1.891092e-10 FALSE TRUE
ENST00000543888 ENSG00000111731 HEK293_OSMI2_6hA HEK293_TMG_6hB C2CD5 protein_coding retained_intron 10.86901 3.614652 19.47391 0.3524476 0.9152598 2.426369 0.7387398 0.37229045 1.025277 0.25677210 0.1814320 1.437276 0.08721667 0.1138000 0.05263333 -0.06116667 9.923740e-01 1.891092e-10   FALSE
MSTRG.6949.5 ENSG00000111731 HEK293_OSMI2_6hA HEK293_TMG_6hB C2CD5 protein_coding   10.86901 3.614652 19.47391 0.3524476 0.9152598 2.426369 0.8003049 0.01070757 1.122362 0.01070757 0.6415533 5.773033 0.04495833 0.0025000 0.06083333 0.05833333 6.600129e-01 1.891092e-10 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000111731 E001 177.3013411 1.5742562749 3.088813e-01 0.5493787347 12 22448583 22449544 962 - 1.996 2.471 1.589
ENSG00000111731 E002 29.2773873 0.7005248666 1.876185e-01 0.4139062787 12 22449545 22449580 36 - 1.245 1.678 1.491
ENSG00000111731 E003 37.0634812 0.7825865048 2.253562e-01 0.4597628612 12 22449581 22449655 75 - 1.351 1.762 1.407
ENSG00000111731 E004 67.4905336 0.9722336828 2.643343e-01 0.5035514156 12 22449656 22449814 159 - 1.606 2.010 1.363
ENSG00000111731 E005 54.2102904 0.3663061732 1.282990e-01 0.3291207281 12 22449815 22449891 77 - 1.520 1.903 1.299
ENSG00000111731 E006 62.1376958 0.0361772281 7.716105e-03 0.0479972211 12 22453896 22454042 147 - 1.595 1.926 1.121
ENSG00000111731 E007 92.3545630 0.0034807347 2.544104e-01 0.4929008299 12 22456971 22457161 191 - 1.807 1.959 0.512
ENSG00000111731 E008 15.9465655 0.0041546026 4.876283e-01 0.6923901488 12 22458484 22458555 72 - 1.068 1.229 0.575
ENSG00000111731 E009 11.4679748 0.0033621650 4.850578e-02 0.1762067525 12 22458556 22458585 30 - 0.903 1.209 1.119
ENSG00000111731 E010 6.2705147 0.1734932923 2.749621e-01 0.5149642062 12 22458586 22458864 279 - 0.662 1.034 1.451
ENSG00000111731 E011 21.0918665 0.0169211662 4.359064e-01 0.6557033067 12 22459492 22459542 51 - 1.177 1.348 0.600
ENSG00000111731 E012 71.7091806 0.0102953045 4.593990e-01 0.6727403563 12 22469709 22469795 87 - 1.719 1.756 0.125
ENSG00000111731 E013 42.4837126 0.0021753581 1.565579e-01 0.3716557596 12 22470824 22470835 12 - 1.507 1.496 -0.036
ENSG00000111731 E014 57.3852094 0.0025814522 1.397400e-01 0.3470925731 12 22470836 22470896 61 - 1.633 1.630 -0.007
ENSG00000111731 E015 36.3231961 0.0052467087 4.674630e-01 0.6783793786 12 22470897 22470911 15 - 1.432 1.464 0.109
ENSG00000111731 E016 58.2416357 0.0082802365 3.512401e-01 0.5884018854 12 22471399 22471488 90 - 1.636 1.659 0.079
ENSG00000111731 E017 57.5916957 0.0071575111 7.774929e-01 0.8832146164 12 22471967 22472065 99 - 1.623 1.699 0.260
ENSG00000111731 E018 55.0012050 0.0061914164 3.469434e-01 0.5844968216 12 22472286 22472347 62 - 1.609 1.637 0.094
ENSG00000111731 E019 0.7013366 0.0917065059 7.300865e-01   12 22472348 22472445 98 - 0.150 0.247 0.890
ENSG00000111731 E020 53.8141840 0.0009480809 8.981620e-01 0.9508631254 12 22472744 22472807 64 - 1.594 1.681 0.297
ENSG00000111731 E021 67.5599251 0.0063921204 9.797759e-01 0.9917090175 12 22474751 22474891 141 - 1.686 1.786 0.339
ENSG00000111731 E022 0.1614157 0.0329686558 1.000000e+00   12 22477262 22477338 77 - 0.056 0.000 -9.237
ENSG00000111731 E023 0.5474829 0.2039755456 5.096613e-03   12 22478028 22478312 285 - 0.000 0.522 15.753
ENSG00000111731 E024 78.5494859 0.0022525915 9.339529e-01 0.9690934950 12 22478313 22478477 165 - 1.751 1.844 0.312
ENSG00000111731 E025 30.7412067 0.0037568028 5.765467e-01 0.7548050437 12 22482557 22482561 5 - 1.345 1.485 0.482
ENSG00000111731 E026 76.7971628 0.0048011284 3.185364e-01 0.5584082093 12 22482562 22482743 182 - 1.752 1.792 0.136
ENSG00000111731 E027 0.6434498 0.0193240943 4.994762e-01   12 22484338 22484696 359 - 0.190 0.000 -11.237
ENSG00000111731 E028 41.5077231 0.0517890747 1.760980e-01 0.3985962854 12 22484697 22484742 46 - 1.503 1.464 -0.135
ENSG00000111731 E029 33.3244807 0.0016717052 1.160641e-01 0.3092847459 12 22484743 22484754 12 - 1.410 1.376 -0.118
ENSG00000111731 E030 37.1409113 0.0088233141 1.266830e-01 0.3265354005 12 22484755 22484794 40 - 1.456 1.424 -0.110
ENSG00000111731 E031 49.6729039 0.0048834185 2.803629e-02 0.1213571985 12 22484795 22484888 94 - 1.582 1.515 -0.229
ENSG00000111731 E032 54.4470144 0.0071141499 2.921049e-02 0.1250028496 12 22490123 22490218 96 - 1.619 1.545 -0.252
ENSG00000111731 E033 63.5747384 0.0126969095 3.610618e-03 0.0269903130 12 22493223 22493337 115 - 1.693 1.536 -0.535
ENSG00000111731 E034 0.1779838 0.0435127956 1.000000e+00   12 22502739 22502804 66 - 0.056 0.000 -9.239
ENSG00000111731 E035 60.1657130 0.0151029609 4.976288e-03 0.0345029536 12 22506711 22506819 109 - 1.671 1.507 -0.559
ENSG00000111731 E036 0.4820342 0.0214489978 7.408056e-01   12 22506820 22506967 148 - 0.150 0.000 -10.822
ENSG00000111731 E037 0.4986023 0.0860220585 7.400798e-01   12 22512647 22512679 33 - 0.150 0.000 -10.827
ENSG00000111731 E038 56.4966481 0.0180581252 4.090088e-02 0.1570388230 12 22513294 22513379 86 - 1.638 1.542 -0.327
ENSG00000111731 E039 64.6784552 0.0201961499 5.077018e-02 0.1815146332 12 22517986 22518095 110 - 1.695 1.621 -0.250
ENSG00000111731 E040 45.9610964 0.0139097815 3.584199e-02 0.1438108629 12 22518096 22518137 42 - 1.552 1.459 -0.322
ENSG00000111731 E041 2.0838254 0.0437579265 7.005757e-01 0.8359838045 12 22519040 22519114 75 - 0.421 0.400 -0.114
ENSG00000111731 E042 3.5299279 0.0075152159 1.957594e-01 0.4243069650 12 22519115 22519239 125 - 0.588 0.401 -0.923
ENSG00000111731 E043 86.3244798 0.0005140340 5.167068e-04 0.0058285421 12 22523426 22523624 199 - 1.820 1.733 -0.294
ENSG00000111731 E044 79.0838307 0.0005330269 1.418846e-03 0.0130347751 12 22524472 22524627 156 - 1.781 1.702 -0.267
ENSG00000111731 E045 70.4206248 0.0073908544 1.224543e-03 0.0116130849 12 22525610 22525705 96 - 1.737 1.597 -0.475
ENSG00000111731 E046 89.1007877 0.0028633569 4.900555e-05 0.0008177528 12 22527721 22527892 172 - 1.838 1.694 -0.484
ENSG00000111731 E047 0.1614157 0.0329686558 1.000000e+00   12 22534707 22535257 551 - 0.056 0.000 -9.237
ENSG00000111731 E048 50.0897398 0.0007883505 1.224076e-05 0.0002498212 12 22535258 22535344 87 - 1.604 1.376 -0.784
ENSG00000111731 E049 51.4511547 0.0125548631 3.145051e-02 0.1316340644 12 22544061 22544179 119 - 1.599 1.513 -0.293
ENSG00000111731 E050 6.0989033 0.0046617893 4.784540e-01 0.6860397706 12 22544180 22544319 140 - 0.709 0.893 0.731
ENSG00000111731 E051 29.0048336 0.0408644586 1.737579e-01 0.3955506795 12 22544320 22544546 227 - 1.358 1.263 -0.334