ENSG00000111726

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000229329 ENSG00000111726 HEK293_OSMI2_6hA HEK293_TMG_6hB CMAS protein_coding protein_coding 38.41734 21.10971 50.35956 4.77041 1.553581 1.253962 33.879561 20.63181 38.12267 4.677952 1.350646 0.8854581 0.89483333 0.9768667 0.7580667 -0.2188 7.331696e-15 1.252512e-19 FALSE TRUE
ENST00000538498 ENSG00000111726 HEK293_OSMI2_6hA HEK293_TMG_6hB CMAS protein_coding protein_coding 38.41734 21.10971 50.35956 4.77041 1.553581 1.253962 3.411073 0.00000 10.55984 0.000000 1.736175 10.0457375 0.07120417 0.0000000 0.2092000 0.2092 1.252512e-19 1.252512e-19 FALSE FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000111726 E001 4.851951 0.0055253459 0.8971650841 0.950405397 12 22046218 22046224 7 + 0.755 0.782 0.111
ENSG00000111726 E002 47.283462 0.0108434709 0.0037581844 0.027783995 12 22046225 22046286 62 + 1.579 1.792 0.721
ENSG00000111726 E003 162.210668 0.0022561149 0.0005091672 0.005762771 12 22046287 22046563 277 + 2.148 2.280 0.443
ENSG00000111726 E004 1.166065 0.1187800893 0.9550560590   12 22055119 22055148 30 + 0.346 0.352 0.040
ENSG00000111726 E005 211.508205 0.0004011970 0.1465958173 0.357332324 12 22055149 22055291 143 + 2.326 2.301 -0.083
ENSG00000111726 E006 265.803933 0.0002363864 0.0004050502 0.004778855 12 22055455 22055610 156 + 2.437 2.370 -0.223
ENSG00000111726 E007 271.098893 0.0009679637 0.0249767748 0.112153116 12 22058567 22058700 134 + 2.438 2.394 -0.146
ENSG00000111726 E008 1.769106 0.0116848328 0.4837185090 0.689605765 12 22060642 22060831 190 + 0.473 0.355 -0.637
ENSG00000111726 E009 252.336651 0.0002531583 0.0286912026 0.123446316 12 22060832 22060926 95 + 2.407 2.369 -0.128
ENSG00000111726 E010 321.994142 0.0037090960 0.6952070949 0.832408444 12 22061281 22061452 172 + 2.500 2.490 -0.033
ENSG00000111726 E011 328.436761 0.0002080093 0.7201893160 0.848307336 12 22062281 22062434 154 + 2.504 2.508 0.014
ENSG00000111726 E012 414.055757 0.0030408328 0.0038198757 0.028140845 12 22065121 22065674 554 + 2.567 2.657 0.298