ENSG00000111707

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000541591 ENSG00000111707 HEK293_OSMI2_6hA HEK293_TMG_6hB SUDS3 protein_coding processed_transcript 19.64117 14.9701 22.97692 1.860078 0.6116727 0.6177661 2.266211 1.67973 0.00000 1.084438 0.0000000 -7.4006491 0.1339167 0.1012667 0.0000000 -0.10126667 0.0001322963 0.0001322963   FALSE
ENST00000543473 ENSG00000111707 HEK293_OSMI2_6hA HEK293_TMG_6hB SUDS3 protein_coding protein_coding 19.64117 14.9701 22.97692 1.860078 0.6116727 0.6177661 16.016341 12.45017 21.32369 1.090859 0.8737059 0.7758099 0.8019917 0.8417667 0.9273333 0.08556667 0.4479221018 0.0001322963 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000111707 E001 12.4298237 0.0033523961 0.2054634385 0.436449823 12 118376555 118376569 15 + 1.048 1.219 0.611
ENSG00000111707 E002 90.5455911 0.0005141679 0.8871591871 0.945197422 12 118376570 118376833 264 + 1.923 1.982 0.200
ENSG00000111707 E003 85.2122541 0.0020244541 0.0058333304 0.038918585 12 118380162 118380231 70 + 1.945 1.879 -0.222
ENSG00000111707 E004 101.4143865 0.0025213416 0.0227779359 0.105232606 12 118384012 118384067 56 + 2.014 1.972 -0.140
ENSG00000111707 E005 128.9026990 0.0003711421 0.0017354938 0.015266862 12 118386114 118386185 72 + 2.117 2.071 -0.156
ENSG00000111707 E006 93.5366905 0.0004580128 0.0002722269 0.003450286 12 118389927 118389946 20 + 1.992 1.908 -0.284
ENSG00000111707 E007 171.3775490 0.0004128207 0.0415940524 0.158872422 12 118391126 118391282 157 + 2.225 2.222 -0.009
ENSG00000111707 E008 103.2090678 0.0008351233 0.8734668036 0.937864100 12 118400659 118400754 96 + 1.986 2.034 0.161
ENSG00000111707 E009 63.8829867 0.0070287224 0.5282747425 0.720831137 12 118401759 118401771 13 + 1.796 1.814 0.060
ENSG00000111707 E010 79.4539337 0.0037970227 0.0947850993 0.272585009 12 118401772 118401820 49 + 1.906 1.878 -0.097
ENSG00000111707 E011 75.5822256 0.0005406091 0.0241831520 0.109654856 12 118401983 118402004 22 + 1.887 1.846 -0.137
ENSG00000111707 E012 8.1542535 0.0708595151 0.5396813439 0.728760663 12 118402233 118402648 416 + 0.866 1.056 0.709
ENSG00000111707 E013 124.5317598 0.0027655817 0.0164766979 0.083565950 12 118403412 118403500 89 + 2.101 2.061 -0.136
ENSG00000111707 E014 72.0490748 0.0055926248 0.0297672799 0.126635657 12 118403501 118403517 17 + 1.871 1.809 -0.210
ENSG00000111707 E015 0.4929928 0.0217681645 0.7853329614   12 118404056 118404473 418 + 0.179 0.149 -0.314
ENSG00000111707 E016 114.3624110 0.0030788230 0.1025801404 0.286379536 12 118411073 118411157 85 + 2.053 2.040 -0.042
ENSG00000111707 E017 118.6243878 0.0027550065 0.9117675064 0.958040228 12 118414335 118414470 136 + 2.040 2.091 0.171
ENSG00000111707 E018 1615.0153582 0.0078283632 0.0044066126 0.031416632 12 118414471 118418033 3563 + 3.142 3.271 0.430
ENSG00000111707 E019 0.2027342 0.0356379365 0.3484636859   12 118431823 118431969 147 + 0.000 0.149 9.031