ENSG00000111678

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000229281 ENSG00000111678 HEK293_OSMI2_6hA HEK293_TMG_6hB C12orf57 protein_coding protein_coding 248.6071 376.9541 83.78029 84.72561 4.557287 -2.169572 199.82264 311.42091 59.724753 70.051787 4.3622347 -2.3822697 0.78187083 0.82580000 0.7114667 -0.114333333 8.665353e-05 2.503157e-09 FALSE TRUE
ENST00000458811 ENSG00000111678 HEK293_OSMI2_6hA HEK293_TMG_6hB C12orf57 protein_coding snRNA 248.6071 376.9541 83.78029 84.72561 4.557287 -2.169572 18.80657 23.72378 13.662608 5.785052 0.3621219 -0.7956534 0.09834167 0.06216667 0.1642667 0.102100000 2.503157e-09 2.503157e-09   FALSE
ENST00000537087 ENSG00000111678 HEK293_OSMI2_6hA HEK293_TMG_6hB C12orf57 protein_coding protein_coding 248.6071 376.9541 83.78029 84.72561 4.557287 -2.169572 25.10478 35.73335 7.174142 8.232596 0.7333339 -2.3147870 0.09603333 0.09466667 0.0852000 -0.009466667 7.982230e-01 2.503157e-09   FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000111678 E001 5.277481 0.6076920174 1.350219e-02 7.238634e-02 12 6942978 6943244 267 + 1.200 0.451 -3.026
ENSG00000111678 E002 3.565239 0.0072775929 1.448556e-06 3.922789e-05 12 6943433 6943501 69 + 1.062 0.362 -3.017
ENSG00000111678 E003 2.655488 0.0206049472 1.897083e-03 1.638116e-02 12 6943502 6943541 40 + 0.854 0.339 -2.380
ENSG00000111678 E004 5.708130 0.0052790331 2.129516e-03 1.793853e-02 12 6943542 6943662 121 + 1.027 0.610 -1.650
ENSG00000111678 E005 2.025090 0.2364584649 1.382611e-01 3.449125e-01 12 6943816 6943816 1 + 0.654 0.296 -1.842
ENSG00000111678 E006 16.716378 0.0083579337 5.368392e-04 6.010921e-03 12 6943817 6943833 17 + 1.360 1.011 -1.242
ENSG00000111678 E007 109.993758 0.0004539459 6.103708e-05 9.876607e-04 12 6943834 6944021 188 + 1.993 1.848 -0.488
ENSG00000111678 E008 838.307371 0.6238575822 3.869732e-01 6.181110e-01 12 6944022 6944106 85 + 2.651 2.741 0.298
ENSG00000111678 E009 898.554704 0.6315207658 3.498751e-01 5.871363e-01 12 6944107 6944121 15 + 2.658 2.773 0.384
ENSG00000111678 E010 1032.437028 0.7244186956 3.895163e-01 6.200835e-01 12 6944122 6944173 52 + 2.736 2.832 0.317
ENSG00000111678 E011 28.955220 0.0099217163 1.787872e-01 4.023488e-01 12 6944380 6944475 96 + 1.392 1.289 -0.357
ENSG00000111678 E012 1273.717206 0.8859870031 4.398536e-01 6.586037e-01 12 6944476 6944565 90 + 2.846 2.921 0.250
ENSG00000111678 E013 1025.415292 0.0001424769 8.393859e-01 9.190432e-01 12 6944566 6944652 87 + 2.783 2.832 0.163
ENSG00000111678 E014 17.764346 0.2782193531 1.310323e-02 7.086718e-02 12 6944653 6945098 446 + 1.487 1.000 -1.723
ENSG00000111678 E015 975.669325 0.3068780510 2.964977e-01 5.370207e-01 12 6945771 6946003 233 + 2.804 2.796 -0.025