ENSG00000111647

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000279907 ENSG00000111647 HEK293_OSMI2_6hA HEK293_TMG_6hB UHRF1BP1L protein_coding protein_coding 5.641253 1.834809 10.34704 0.673212 0.4604232 2.489069 4.1360241 0.89646368 8.26079137 0.22388132 0.41134540 3.1897043 0.56544167 0.56076667 0.801466667 0.2407000 3.029383e-01 6.441289e-05 FALSE TRUE
ENST00000356828 ENSG00000111647 HEK293_OSMI2_6hA HEK293_TMG_6hB UHRF1BP1L protein_coding protein_coding 5.641253 1.834809 10.34704 0.673212 0.4604232 2.489069 0.1888886 0.03854286 0.05630811 0.02206016 0.02823530 0.4499264 0.05418333 0.02886667 0.005266667 -0.0236000 5.486839e-01 6.441289e-05 FALSE TRUE
ENST00000545232 ENSG00000111647 HEK293_OSMI2_6hA HEK293_TMG_6hB UHRF1BP1L protein_coding protein_coding 5.641253 1.834809 10.34704 0.673212 0.4604232 2.489069 0.4646232 0.41519391 0.49366751 0.16976725 0.49366751 0.2443507 0.18186667 0.23730000 0.044166667 -0.1931333 2.291531e-01 6.441289e-05 FALSE TRUE
ENST00000548712 ENSG00000111647 HEK293_OSMI2_6hA HEK293_TMG_6hB UHRF1BP1L protein_coding protein_coding 5.641253 1.834809 10.34704 0.673212 0.4604232 2.489069 0.3011477 0.47628804 0.00000000 0.47628804 0.00000000 -5.6037392 0.11603333 0.16013333 0.000000000 -0.1601333 6.440482e-01 6.441289e-05 FALSE TRUE
MSTRG.7845.1 ENSG00000111647 HEK293_OSMI2_6hA HEK293_TMG_6hB UHRF1BP1L protein_coding   5.641253 1.834809 10.34704 0.673212 0.4604232 2.489069 0.3386608 0.00000000 1.24595716 0.00000000 0.09491432 6.9726434 0.03560000 0.00000000 0.121000000 0.1210000 6.441289e-05 6.441289e-05 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000111647 E001 1.4155550 0.0122836659 8.748179e-01 9.386520e-01 12 100028455 100028551 97 - 0.307 0.258 -0.344
ENSG00000111647 E002 2.6107943 0.4227863882 5.236281e-01 7.175538e-01 12 100028552 100028610 59 - 0.386 0.656 1.298
ENSG00000111647 E003 3.1036851 0.0114787266 6.912841e-01 8.298845e-01 12 100037072 100037142 71 - 0.503 0.419 -0.428
ENSG00000111647 E004 2.5991134 0.0090494927 3.544496e-01 5.912471e-01 12 100037143 100037180 38 - 0.466 0.258 -1.250
ENSG00000111647 E005 81.2830802 0.0005618007 1.419836e-02 7.512486e-02 12 100037181 100037755 575 - 1.739 1.864 0.422
ENSG00000111647 E006 56.8392702 0.0011950478 2.584720e-06 6.522213e-05 12 100039596 100039789 194 - 1.557 1.829 0.922
ENSG00000111647 E007 47.4247020 0.0009977788 1.213781e-03 1.153680e-02 12 100047530 100047638 109 - 1.494 1.703 0.712
ENSG00000111647 E008 67.2487977 0.0031672427 7.734633e-02 2.395227e-01 12 100047943 100048196 254 - 1.661 1.772 0.378
ENSG00000111647 E009 45.6356781 0.0041693959 4.168682e-01 6.412901e-01 12 100050168 100050264 97 - 1.507 1.572 0.220
ENSG00000111647 E010 34.9012164 0.0015864539 6.388363e-01 7.961948e-01 12 100050265 100050318 54 - 1.403 1.442 0.137
ENSG00000111647 E011 49.4616914 0.0013662562 5.171697e-01 7.131213e-01 12 100051079 100051221 143 - 1.546 1.592 0.156
ENSG00000111647 E012 0.8567829 0.1733615627 6.467634e-01   12 100051222 100051874 653 - 0.218 0.001 -8.750
ENSG00000111647 E013 44.6052246 0.0010862069 2.616918e-02 1.158260e-01 12 100057571 100057746 176 - 1.483 1.635 0.519
ENSG00000111647 E014 161.1527750 0.0041175701 7.040433e-01 8.381487e-01 12 100058029 100059038 1010 - 2.056 2.036 -0.069
ENSG00000111647 E015 89.1353821 0.0016776081 3.837037e-01 6.153115e-01 12 100059039 100059533 495 - 1.804 1.755 -0.167
ENSG00000111647 E016 39.1493123 0.0044118265 4.104371e-01 6.363996e-01 12 100059850 100060043 194 - 1.463 1.389 -0.255
ENSG00000111647 E017 0.6791589 0.0216741646 8.046826e-02   12 100069908 100070169 262 - 0.099 0.419 2.662
ENSG00000111647 E018 18.8742545 0.0105593045 4.229589e-01 6.458211e-01 12 100072672 100072678 7 - 1.167 1.062 -0.377
ENSG00000111647 E019 30.3767778 0.0098407778 9.934021e-01 9.983479e-01 12 100072679 100072778 100 - 1.349 1.342 -0.025
ENSG00000111647 E020 20.0309490 0.0022422230 8.765716e-01 9.394711e-01 12 100072779 100072785 7 - 1.176 1.192 0.059
ENSG00000111647 E021 19.9166490 0.0026201298 9.515547e-01 9.777197e-01 12 100072786 100072813 28 - 1.176 1.169 -0.024
ENSG00000111647 E022 42.9861660 0.0009269823 7.512402e-03 4.708934e-02 12 100083016 100083134 119 - 1.518 1.293 -0.779
ENSG00000111647 E023 32.6028611 0.0011019146 5.272565e-02 1.860539e-01 12 100084476 100084532 57 - 1.396 1.215 -0.634
ENSG00000111647 E024 44.5630332 0.0009286384 6.511209e-02 2.141521e-01 12 100084533 100084658 126 - 1.522 1.375 -0.506
ENSG00000111647 E025 38.6625404 0.0026862917 4.447136e-01 6.619335e-01 12 100086275 100086358 84 - 1.454 1.389 -0.224
ENSG00000111647 E026 49.9059722 0.0010287841 3.246371e-01 5.639008e-01 12 100088915 100089095 181 - 1.563 1.491 -0.246
ENSG00000111647 E027 0.0000000       12 100092722 100092902 181 -      
ENSG00000111647 E028 0.0000000       12 100092903 100092908 6 -      
ENSG00000111647 E029 0.0000000       12 100092909 100092964 56 -      
ENSG00000111647 E030 48.2756479 0.0071461312 2.389950e-01 4.754729e-01 12 100095667 100095837 171 - 1.554 1.454 -0.342
ENSG00000111647 E031 43.0908174 0.0010589213 1.469928e-01 3.579967e-01 12 100097365 100097505 141 - 1.505 1.389 -0.398
ENSG00000111647 E032 47.8237858 0.0013344047 1.821266e-01 4.067646e-01 12 100098352 100098541 190 - 1.545 1.443 -0.349
ENSG00000111647 E033 36.1813062 0.0011818396 3.185990e-01 5.584444e-01 12 100102766 100102857 92 - 1.428 1.344 -0.293
ENSG00000111647 E034 23.3552259 0.0014823936 7.854496e-01 8.878129e-01 12 100103913 100103934 22 - 1.241 1.215 -0.095
ENSG00000111647 E035 21.5893281 0.0015723911 1.441105e-01 3.535393e-01 12 100103935 100103951 17 - 1.225 1.062 -0.585
ENSG00000111647 E036 33.4652493 0.0011514625 4.255499e-02 1.613885e-01 12 100108386 100108548 163 - 1.405 1.215 -0.664
ENSG00000111647 E037 1.1364427 0.0142084776 1.000000e+00   12 100128580 100128725 146 - 0.248 0.258 0.073
ENSG00000111647 E038 22.2799957 0.0015726716 3.094590e-01 5.499446e-01 12 100142592 100142874 283 - 1.229 1.119 -0.390