ENSG00000111639

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000229238 ENSG00000111639 HEK293_OSMI2_6hA HEK293_TMG_6hB MRPL51 protein_coding protein_coding 280.2722 205.9097 254.7222 25.61462 16.17808 0.3068993 175.98850 146.83009 141.09379 18.801285 8.4810085 -0.05748914 0.6260042 0.7122000 0.5541667 -0.15803333 1.734255e-06 1.734255e-06 FALSE FALSE
ENST00000537701 ENSG00000111639 HEK293_OSMI2_6hA HEK293_TMG_6hB MRPL51 protein_coding protein_coding 280.2722 205.9097 254.7222 25.61462 16.17808 0.3068993 43.45753 24.76434 48.22222 1.842286 4.4517007 0.96115057 0.1563708 0.1220667 0.1887667 0.06670000 2.894403e-02 1.734255e-06 FALSE FALSE
ENST00000543164 ENSG00000111639 HEK293_OSMI2_6hA HEK293_TMG_6hB MRPL51 protein_coding protein_coding 280.2722 205.9097 254.7222 25.61462 16.17808 0.3068993 43.08804 26.59533 47.45148 2.937708 0.5011031 0.83504182 0.1554042 0.1296000 0.1877667 0.05816667 4.960773e-02 1.734255e-06   FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000111639 E001 10.984140 0.0172033152 1.000000e+00 1.000000e+00 12 6491886 6492102 217 - 1.078 1.088 0.037
ENSG00000111639 E002 9.783771 0.0126160288 7.365842e-01 8.583240e-01 12 6492103 6492146 44 - 1.002 1.060 0.212
ENSG00000111639 E003 17.396723 0.0051715492 1.215694e-03 1.155154e-02 12 6492147 6492150 4 - 1.051 1.359 1.093
ENSG00000111639 E004 17.224348 0.0076834954 2.382908e-03 1.958067e-02 12 6492151 6492151 1 - 1.050 1.354 1.076
ENSG00000111639 E005 627.437606 0.0038539071 6.630615e-01 8.118102e-01 12 6492152 6492280 129 - 2.789 2.790 0.002
ENSG00000111639 E006 1702.069152 0.0009463390 7.683389e-02 2.384620e-01 12 6492281 6492467 187 - 3.233 3.217 -0.054
ENSG00000111639 E007 1751.687708 0.0001135839 1.412653e-01 3.493977e-01 12 6492862 6492972 111 - 3.233 3.241 0.028
ENSG00000111639 E008 9.148358 0.1806501115 7.926207e-01 8.919452e-01 12 6492973 6493046 74 - 0.882 1.059 0.657
ENSG00000111639 E009 1522.234357 0.0007816479 3.745132e-07 1.199113e-05 12 6493058 6493250 193 - 3.127 3.205 0.261
ENSG00000111639 E010 184.923245 0.0022675239 3.712807e-02 1.472558e-01 12 6493251 6493295 45 - 2.217 2.292 0.251
ENSG00000111639 E011 252.427997 0.0002758482 5.592004e-12 5.045967e-10 12 6493459 6493673 215 - 2.494 2.329 -0.550
ENSG00000111639 E012 137.282270 0.0011255280 4.700305e-06 1.091061e-04 12 6493674 6493716 43 - 2.228 2.067 -0.538
ENSG00000111639 E013 227.304197 0.0067915574 2.177617e-04 2.869632e-03 12 6493717 6493841 125 - 2.451 2.274 -0.587