ENSG00000111602

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000229201 ENSG00000111602 HEK293_OSMI2_6hA HEK293_TMG_6hB TIMELESS protein_coding protein_coding 68.63298 86.17451 50.60968 3.209544 1.21506 -0.7677302 41.745203 54.377561 26.709825 7.5019134 0.8304654 -1.02536620 0.5942250 0.6264667 0.52776667 -0.09870000 0.675788652 0.008185371 FALSE TRUE
ENST00000553532 ENSG00000111602 HEK293_OSMI2_6hA HEK293_TMG_6hB TIMELESS protein_coding protein_coding 68.63298 86.17451 50.60968 3.209544 1.21506 -0.7677302 8.862524 11.568287 4.701207 0.4346728 0.5179744 -1.29725305 0.1248833 0.1349000 0.09276667 -0.04213333 0.329299400 0.008185371 FALSE TRUE
ENST00000557589 ENSG00000111602 HEK293_OSMI2_6hA HEK293_TMG_6hB TIMELESS protein_coding retained_intron 68.63298 86.17451 50.60968 3.209544 1.21506 -0.7677302 7.618708 8.664666 7.093153 2.7695485 0.2003416 -0.28834873 0.1138875 0.1030333 0.14036667 0.03733333 0.731555636 0.008185371 TRUE TRUE
MSTRG.7463.4 ENSG00000111602 HEK293_OSMI2_6hA HEK293_TMG_6hB TIMELESS protein_coding   68.63298 86.17451 50.60968 3.209544 1.21506 -0.7677302 8.211117 9.735485 9.464288 0.3491682 0.0514816 -0.04071646 0.1320167 0.1135667 0.18716667 0.07360000 0.008185371 0.008185371 TRUE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000111602 E001 121.3685064 0.0133492185 1.845742e-01 4.099362e-01 12 56416363 56417118 756 - 1.984 2.077 0.314
ENSG00000111602 E002 25.4662663 0.0051667043 7.853080e-01 8.877043e-01 12 56417119 56417126 8 - 1.366 1.387 0.074
ENSG00000111602 E003 302.6504199 0.0001833543 6.650509e-06 1.474232e-04 12 56417127 56417308 182 - 2.369 2.473 0.347
ENSG00000111602 E004 1252.5996116 0.0014415538 1.362389e-05 2.741196e-04 12 56417309 56417786 478 - 2.996 3.087 0.304
ENSG00000111602 E005 699.2134508 0.0004928112 3.939806e-05 6.795345e-04 12 56417907 56418008 102 - 2.755 2.829 0.246
ENSG00000111602 E006 700.6363984 0.0012054056 9.581358e-03 5.632220e-02 12 56418134 56418289 156 - 2.768 2.826 0.192
ENSG00000111602 E007 474.8253897 0.0011348816 1.532663e-02 7.929849e-02 12 56418290 56418359 70 - 2.598 2.656 0.194
ENSG00000111602 E008 615.0147987 0.0019937346 7.775087e-03 4.825453e-02 12 56420569 56420687 119 - 2.702 2.773 0.237
ENSG00000111602 E009 8.0902311 0.0071743915 8.074753e-01 9.006640e-01 12 56420688 56420812 125 - 0.941 0.910 -0.117
ENSG00000111602 E010 447.7601716 0.0042678814 1.307682e-01 3.330002e-01 12 56420813 56420881 69 - 2.575 2.632 0.188
ENSG00000111602 E011 730.0130336 0.0016723304 4.351731e-02 1.639022e-01 12 56420963 56421134 172 - 2.791 2.841 0.166
ENSG00000111602 E012 125.7093324 0.1082111678 6.980957e-02 2.244169e-01 12 56421135 56421350 216 - 2.208 1.987 -0.739
ENSG00000111602 E013 666.4030988 0.0001324320 4.891190e-04 5.575490e-03 12 56421351 56421493 143 - 2.747 2.801 0.180
ENSG00000111602 E014 31.8163611 0.1616131674 6.159145e-02 2.063779e-01 12 56421494 56421551 58 - 1.653 1.376 -0.951
ENSG00000111602 E015 51.4264669 0.1445368491 2.701413e-02 1.183474e-01 12 56421552 56421726 175 - 1.883 1.556 -1.106
ENSG00000111602 E016 549.6062524 0.0001227707 8.492194e-04 8.682539e-03 12 56421727 56421809 83 - 2.662 2.718 0.187
ENSG00000111602 E017 23.6086786 0.0914608818 1.991383e-02 9.557500e-02 12 56421810 56421898 89 - 1.560 1.224 -1.167
ENSG00000111602 E018 598.5923467 0.0003126465 7.636544e-01 8.748564e-01 12 56421899 56422016 118 - 2.742 2.736 -0.019
ENSG00000111602 E019 495.1498489 0.0001587283 3.177335e-02 1.325466e-01 12 56422106 56422191 86 - 2.682 2.643 -0.129
ENSG00000111602 E020 0.9396101 0.8323410364 8.613616e-01   12 56422192 56422221 30 - 0.285 0.292 0.044
ENSG00000111602 E021 566.9450618 0.0001266202 2.520993e-02 1.128420e-01 12 56422847 56422992 146 - 2.740 2.703 -0.125
ENSG00000111602 E022 630.1061567 0.0002711283 7.258839e-01 8.516420e-01 12 56423274 56423475 202 - 2.757 2.762 0.018
ENSG00000111602 E023 274.5606699 0.0002567812 5.138018e-02 1.830212e-01 12 56423584 56423624 41 - 2.367 2.414 0.155
ENSG00000111602 E024 385.4254737 0.0001855619 3.322574e-01 5.710622e-01 12 56423625 56423707 83 - 2.533 2.552 0.063
ENSG00000111602 E025 365.5979953 0.0001636835 6.954910e-01 8.325601e-01 12 56423797 56423894 98 - 2.520 2.527 0.024
ENSG00000111602 E026 522.4733490 0.0001534101 4.330882e-01 6.535205e-01 12 56424762 56424913 152 - 2.672 2.685 0.044
ENSG00000111602 E027 523.7168896 0.0001298470 8.013092e-01 8.970821e-01 12 56425015 56425152 138 - 2.679 2.683 0.012
ENSG00000111602 E028 593.4456933 0.0007780145 1.155389e-01 3.083730e-01 12 56428236 56428405 170 - 2.758 2.726 -0.105
ENSG00000111602 E029 457.7821446 0.0012040957 1.001416e-01 2.820618e-01 12 56428549 56428652 104 - 2.649 2.610 -0.130
ENSG00000111602 E030 596.3841125 0.0001200454 1.789673e-01 4.025959e-01 12 56428883 56429100 218 - 2.752 2.730 -0.074
ENSG00000111602 E031 455.1853952 0.0002185430 6.728403e-02 2.190052e-01 12 56430105 56430281 177 - 2.645 2.610 -0.116
ENSG00000111602 E032 341.8863916 0.0002413319 1.905828e-03 1.644413e-02 12 56430881 56430968 88 - 2.544 2.477 -0.221
ENSG00000111602 E033 473.3881923 0.0022110322 1.362957e-02 7.288977e-02 12 56431471 56431604 134 - 2.687 2.618 -0.228
ENSG00000111602 E034 461.2189030 0.0026465121 5.590806e-02 1.934253e-01 12 56432369 56432521 153 - 2.666 2.610 -0.186
ENSG00000111602 E035 134.0335001 0.0058374781 7.988528e-01 8.956267e-01 12 56432522 56432524 3 - 2.100 2.090 -0.033
ENSG00000111602 E036 331.7142879 0.0002143987 3.536173e-03 2.655990e-02 12 56433026 56433127 102 - 2.528 2.465 -0.210
ENSG00000111602 E037 227.4952141 0.0017812734 4.469859e-05 7.562865e-04 12 56433381 56433443 63 - 2.409 2.281 -0.429
ENSG00000111602 E038 335.1811791 0.0005567763 9.786567e-10 5.723086e-08 12 56433538 56433652 115 - 2.583 2.444 -0.465
ENSG00000111602 E039 413.5579421 0.0017208351 4.067503e-06 9.632626e-05 12 56433773 56433926 154 - 2.664 2.541 -0.410
ENSG00000111602 E040 372.7935651 0.0034249530 8.131086e-04 8.388587e-03 12 56434074 56434231 158 - 2.612 2.500 -0.375
ENSG00000111602 E041 177.9172737 0.0025375944 4.312549e-01 6.521155e-01 12 56449310 56449447 138 - 2.236 2.208 -0.095