ENSG00000111554

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000303145 ENSG00000111554 HEK293_OSMI2_6hA HEK293_TMG_6hB MDM1 protein_coding protein_coding 5.471601 1.753654 11.27546 0.1170939 0.8710227 2.677825 0.56494899 0.45489944 1.0828338 0.22763344 0.5815938 1.233083 0.14260833 0.27556667 0.08910000 -0.18646667 8.688613e-01 8.417491e-05 FALSE TRUE
ENST00000393543 ENSG00000111554 HEK293_OSMI2_6hA HEK293_TMG_6hB MDM1 protein_coding protein_coding 5.471601 1.753654 11.27546 0.1170939 0.8710227 2.677825 0.43025112 0.07547001 0.8445425 0.03806965 0.2168694 3.321662 0.09670000 0.04056667 0.07876667 0.03820000 7.744987e-01 8.417491e-05   FALSE
ENST00000430606 ENSG00000111554 HEK293_OSMI2_6hA HEK293_TMG_6hB MDM1 protein_coding protein_coding 5.471601 1.753654 11.27546 0.1170939 0.8710227 2.677825 0.62534176 0.40412649 1.3298957 0.02368052 0.1668514 1.693977 0.10333333 0.23203333 0.11733333 -0.11470000 1.137494e-01 8.417491e-05 FALSE TRUE
ENST00000536313 ENSG00000111554 HEK293_OSMI2_6hA HEK293_TMG_6hB MDM1 protein_coding retained_intron 5.471601 1.753654 11.27546 0.1170939 0.8710227 2.677825 0.05429037 0.15177828 0.0000000 0.11915622 0.0000000 -4.015946 0.01754583 0.08473333 0.00000000 -0.08473333 1.386443e-01 8.417491e-05 FALSE FALSE
ENST00000538454 ENSG00000111554 HEK293_OSMI2_6hA HEK293_TMG_6hB MDM1 protein_coding retained_intron 5.471601 1.753654 11.27546 0.1170939 0.8710227 2.677825 0.44836635 0.04298117 1.1799247 0.02154332 0.2342356 4.489247 0.06040000 0.02503333 0.10390000 0.07886667 1.656288e-01 8.417491e-05 FALSE FALSE
ENST00000545964 ENSG00000111554 HEK293_OSMI2_6hA HEK293_TMG_6hB MDM1 protein_coding retained_intron 5.471601 1.753654 11.27546 0.1170939 0.8710227 2.677825 0.90644796 0.00000000 2.1684419 0.00000000 0.6128176 7.767153 0.12945000 0.00000000 0.18646667 0.18646667 8.417491e-05 8.417491e-05   FALSE
ENST00000682720 ENSG00000111554 HEK293_OSMI2_6hA HEK293_TMG_6hB MDM1 protein_coding protein_coding 5.471601 1.753654 11.27546 0.1170939 0.8710227 2.677825 0.32570842 0.20035012 0.4844235 0.14213872 0.4844235 1.232955 0.07817083 0.10500000 0.05080000 -0.05420000 6.750956e-01 8.417491e-05 FALSE TRUE
MSTRG.7629.7 ENSG00000111554 HEK293_OSMI2_6hA HEK293_TMG_6hB MDM1 protein_coding   5.471601 1.753654 11.27546 0.1170939 0.8710227 2.677825 0.37760491 0.18373590 0.6691509 0.18373590 0.1561341 1.809641 0.05904583 0.09423333 0.05823333 -0.03600000 8.612880e-01 8.417491e-05 FALSE TRUE
MSTRG.7629.8 ENSG00000111554 HEK293_OSMI2_6hA HEK293_TMG_6hB MDM1 protein_coding   5.471601 1.753654 11.27546 0.1170939 0.8710227 2.677825 0.48290453 0.06566443 1.2062606 0.06566443 0.3605232 4.006693 0.08490000 0.03366667 0.11336667 0.07970000 5.228386e-01 8.417491e-05 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000111554 E001 0.0000000       12 68272443 68272532 90 -      
ENSG00000111554 E002 0.0000000       12 68277624 68277759 136 -      
ENSG00000111554 E003 0.0000000       12 68280648 68280755 108 -      
ENSG00000111554 E004 0.0000000       12 68294566 68294567 2 -      
ENSG00000111554 E005 3.4426367 0.0350039383 0.447164314 0.66360938 12 68294568 68294814 247 - 0.546 0.676 0.571
ENSG00000111554 E006 6.2312898 0.0655464723 0.235787793 0.47177838 12 68294815 68294862 48 - 0.732 0.929 0.769
ENSG00000111554 E007 16.7397624 0.0074465321 0.324263263 0.56353683 12 68294863 68295049 187 - 1.139 1.235 0.339
ENSG00000111554 E008 6.9780809 0.0049030982 0.312220143 0.55253296 12 68295050 68295060 11 - 0.793 0.926 0.515
ENSG00000111554 E009 12.0100071 0.0034752488 0.178493280 0.40193946 12 68295061 68295192 132 - 1.003 1.146 0.521
ENSG00000111554 E010 12.8928280 0.0028671077 0.048188086 0.17544668 12 68295193 68295264 72 - 1.017 1.217 0.720
ENSG00000111554 E011 23.3761023 0.0014701863 0.029695663 0.12642078 12 68295265 68295366 102 - 1.262 1.432 0.590
ENSG00000111554 E012 21.4677332 0.0019170753 0.636535855 0.79470115 12 68296923 68296982 60 - 1.266 1.306 0.139
ENSG00000111554 E013 33.7395239 0.0011460359 0.167790383 0.38765089 12 68302620 68302802 183 - 1.437 1.530 0.317
ENSG00000111554 E014 18.2090410 0.0050291019 0.288121165 0.52887146 12 68302803 68302872 70 - 1.179 1.278 0.348
ENSG00000111554 E015 17.8797315 0.0041710647 0.080393395 0.24563515 12 68313443 68313552 110 - 1.159 1.318 0.562
ENSG00000111554 E016 15.9035214 0.0022811024 0.517574532 0.71333724 12 68313644 68313753 110 - 1.138 1.201 0.221
ENSG00000111554 E017 18.0370667 0.0020655023 0.601682556 0.77123616 12 68314948 68315015 68 - 1.216 1.165 -0.180
ENSG00000111554 E018 36.4546403 0.0009989423 0.295791794 0.53628999 12 68315016 68315221 206 - 1.506 1.432 -0.255
ENSG00000111554 E019 20.8820647 0.0025078392 0.313119549 0.55336752 12 68315222 68315265 44 - 1.278 1.183 -0.336
ENSG00000111554 E020 31.5064188 0.0145927716 0.951117739 0.97753926 12 68316078 68316253 176 - 1.431 1.431 -0.001
ENSG00000111554 E021 5.3248768 0.0479054384 0.510294594 0.70819221 12 68316254 68316408 155 - 0.746 0.615 -0.548
ENSG00000111554 E022 4.6555842 0.0459357790 0.591887113 0.76502982 12 68316581 68316610 30 - 0.713 0.612 -0.428
ENSG00000111554 E023 6.6626169 0.0046421039 0.002661994 0.02135014 12 68320973 68321346 374 - 0.887 0.350 -2.438
ENSG00000111554 E024 14.8258241 0.0286891630 0.620104426 0.78392308 12 68321347 68321372 26 - 1.135 1.062 -0.263
ENSG00000111554 E025 19.4214758 0.0226210311 0.625326235 0.78751466 12 68321373 68321446 74 - 1.243 1.182 -0.218
ENSG00000111554 E026 3.1954475 0.0070531224 0.184323887 0.40960297 12 68321447 68321524 78 - 0.605 0.350 -1.286
ENSG00000111554 E027 12.5611009 0.0026637353 0.285073680 0.52569243 12 68321525 68321551 27 - 1.082 0.957 -0.460
ENSG00000111554 E028 14.4081236 0.0025466083 0.273428957 0.51328152 12 68321552 68321573 22 - 1.134 1.012 -0.440
ENSG00000111554 E029 18.6467668 0.0489150123 0.610758824 0.77743981 12 68321574 68321628 55 - 1.229 1.161 -0.243
ENSG00000111554 E030 23.6120308 0.0015880419 0.642538140 0.79856355 12 68323073 68323240 168 - 1.319 1.278 -0.141
ENSG00000111554 E031 1.1364427 0.0139639788 0.647485304   12 68323241 68323398 158 - 0.303 0.210 -0.700
ENSG00000111554 E032 1.7351283 0.3763813499 0.533000482 0.72418386 12 68325005 68325120 116 - 0.422 0.214 -1.368
ENSG00000111554 E033 1.7808726 0.0981507384 0.856156959 0.92835434 12 68325121 68325171 51 - 0.397 0.354 -0.252
ENSG00000111554 E034 3.4839098 0.0184509312 0.381830242 0.61377015 12 68325172 68325172 1 - 0.621 0.457 -0.772
ENSG00000111554 E035 9.3542131 0.0037886767 0.411775261 0.63734935 12 68325173 68325247 75 - 0.965 0.857 -0.408
ENSG00000111554 E036 11.4239729 0.0051032648 0.716427876 0.84588917 12 68325248 68325440 193 - 1.030 0.986 -0.164
ENSG00000111554 E037 19.5186877 0.0047922927 0.149259708 0.36116626 12 68325441 68325575 135 - 1.203 1.331 0.451
ENSG00000111554 E038 15.3558254 0.0020904316 0.493607731 0.69635024 12 68325576 68325904 329 - 1.117 1.184 0.238
ENSG00000111554 E039 31.7606236 0.0011332076 0.776014318 0.88238752 12 68325905 68326656 752 - 1.432 1.451 0.067
ENSG00000111554 E040 51.2007205 0.0011075608 0.025761076 0.11456016 12 68326657 68327021 365 - 1.660 1.522 -0.471
ENSG00000111554 E041 6.8877712 0.0150482006 0.104161137 0.28910138 12 68327022 68327510 489 - 0.877 0.612 -1.075
ENSG00000111554 E042 0.3206185 0.0274424043 1.000000000   12 68330696 68331106 411 - 0.126 0.001 -8.068
ENSG00000111554 E043 19.7116966 0.0017409344 0.177897273 0.40098016 12 68331107 68331221 115 - 1.258 1.127 -0.466
ENSG00000111554 E044 0.0000000       12 68332001 68332227 227 -      
ENSG00000111554 E045 8.1281979 0.0036580335 0.303034804 0.54359149 12 68332228 68332381 154 - 0.858 0.986 0.482