ENSG00000111450

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000261653 ENSG00000111450 HEK293_OSMI2_6hA HEK293_TMG_6hB STX2 protein_coding protein_coding 13.21104 6.916126 18.56493 0.344952 0.6364742 1.423236 2.761104 2.1313341 3.687055 0.5542819 0.3863236 0.7878667 0.21951667 0.30446667 0.20043333 -0.10403333 7.230837e-01 4.761734e-08 FALSE TRUE
ENST00000392373 ENSG00000111450 HEK293_OSMI2_6hA HEK293_TMG_6hB STX2 protein_coding protein_coding 13.21104 6.916126 18.56493 0.344952 0.6364742 1.423236 5.939622 3.4504477 8.493087 0.4955110 0.7016011 1.2970281 0.46310833 0.49513333 0.45606667 -0.03906667 8.950050e-01 4.761734e-08 FALSE TRUE
ENST00000540889 ENSG00000111450 HEK293_OSMI2_6hA HEK293_TMG_6hB STX2 protein_coding retained_intron 13.21104 6.916126 18.56493 0.344952 0.6364742 1.423236 1.765413 0.7503674 3.045152 0.3713039 0.1151040 2.0064757 0.14511250 0.11276667 0.16473333 0.05196667 7.245373e-01 4.761734e-08 FALSE TRUE
MSTRG.8318.5 ENSG00000111450 HEK293_OSMI2_6hA HEK293_TMG_6hB STX2 protein_coding   13.21104 6.916126 18.56493 0.344952 0.6364742 1.423236 1.238057 0.0000000 1.937304 0.0000000 0.3862974 7.6053344 0.06360833 0.00000000 0.10350000 0.10350000 4.761734e-08 4.761734e-08 FALSE TRUE
MSTRG.8318.6 ENSG00000111450 HEK293_OSMI2_6hA HEK293_TMG_6hB STX2 protein_coding   13.21104 6.916126 18.56493 0.344952 0.6364742 1.423236 1.077836 0.2181223 1.402329 0.2181223 0.1836702 2.6301969 0.07259583 0.03436667 0.07526667 0.04090000 4.494476e-01 4.761734e-08 TRUE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000111450 E001 80.978778 0.0040593390 0.029962396 0.12723623 12 130789600 130789961 362 - 1.853 1.955 0.341
ENSG00000111450 E002 126.485038 0.0008076624 0.019878853 0.09544221 12 130789962 130790203 242 - 2.058 2.133 0.253
ENSG00000111450 E003 333.971810 0.0002174020 0.001704259 0.01504665 12 130790204 130791540 1337 - 2.485 2.542 0.188
ENSG00000111450 E004 34.364606 0.0037829317 0.899044057 0.95137052 12 130791541 130791668 128 - 1.532 1.524 -0.029
ENSG00000111450 E005 114.678896 0.0004107879 0.340255849 0.57818681 12 130791669 130791916 248 - 2.054 2.021 -0.112
ENSG00000111450 E006 50.664820 0.0012104354 0.760725117 0.87301407 12 130791917 130791977 61 - 1.693 1.708 0.054
ENSG00000111450 E007 57.363771 0.0039058112 0.012424851 0.06814585 12 130795995 130796120 126 - 1.792 1.648 -0.490
ENSG00000111450 E008 5.013378 0.0689661346 0.628745046 0.78968272 12 130798393 130798524 132 - 0.790 0.701 -0.360
ENSG00000111450 E009 90.727303 0.0042019229 0.003362707 0.02554986 12 130798525 130798635 111 - 1.990 1.841 -0.501
ENSG00000111450 E010 91.665228 0.0004528628 0.006151156 0.04046515 12 130801153 130801253 101 - 1.983 1.876 -0.361
ENSG00000111450 E011 59.413745 0.0041761361 0.182799286 0.40763008 12 130801254 130801290 37 - 1.788 1.714 -0.250
ENSG00000111450 E012 79.073104 0.0016869904 0.107903165 0.29555564 12 130801415 130801488 74 - 1.909 1.837 -0.241
ENSG00000111450 E013 81.994823 0.0022958052 0.673844602 0.81881963 12 130806982 130807090 109 - 1.893 1.912 0.063
ENSG00000111450 E014 77.274672 0.0022902586 0.755209786 0.86980341 12 130808631 130808704 74 - 1.869 1.883 0.045
ENSG00000111450 E015 0.000000       12 130812310 130812443 134 -      
ENSG00000111450 E016 71.703060 0.0006763768 0.338892035 0.57699373 12 130812957 130813031 75 - 1.855 1.812 -0.143
ENSG00000111450 E017 65.129553 0.0006757923 0.257960318 0.49669601 12 130821689 130821788 100 - 1.818 1.765 -0.177
ENSG00000111450 E018 32.442720 0.0010809008 0.502068946 0.70225114 12 130827193 130827262 70 - 1.488 1.530 0.142
ENSG00000111450 E019 12.262556 0.0049556516 0.027988893 0.12123238 12 130827263 130827267 5 - 1.016 1.230 0.769
ENSG00000111450 E020 16.819370 0.0115423925 0.009312173 0.05513469 12 130839070 130839266 197 - 1.129 1.373 0.857