ENSG00000111371

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000398637 ENSG00000111371 HEK293_OSMI2_6hA HEK293_TMG_6hB SLC38A1 protein_coding protein_coding 25.01618 8.964166 46.17386 2.422259 1.696073 2.363539 20.0711090 8.2879039 37.463536 2.20275271 1.2888558 2.175053 0.84624583 0.9286 0.81153333 -0.11706667 9.780535e-05 9.780535e-05 FALSE TRUE
ENST00000546893 ENSG00000111371 HEK293_OSMI2_6hA HEK293_TMG_6hB SLC38A1 protein_coding protein_coding 25.01618 8.964166 46.17386 2.422259 1.696073 2.363539 2.6566112 0.1079335 3.525300 0.09230401 0.5421958 4.905786 0.07005417 0.0116 0.07640000 0.06480000 7.012199e-02 9.780535e-05 FALSE TRUE
MSTRG.7164.8 ENSG00000111371 HEK293_OSMI2_6hA HEK293_TMG_6hB SLC38A1 protein_coding   25.01618 8.964166 46.17386 2.422259 1.696073 2.363539 0.8934238 0.1435662 3.042539 0.14356619 0.5035568 4.313077 0.02464167 0.0120 0.06553333 0.05353333 2.408497e-01 9.780535e-05 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000111371 E001 2252.4875353 2.250264754 0.440647605 0.65918709 12 46183063 46187800 4738 - 3.124 3.516 1.304
ENSG00000111371 E002 296.8957216 1.543847557 0.555261508 0.73995491 12 46187801 46188564 764 - 2.285 2.534 0.831
ENSG00000111371 E003 214.1324581 1.431364127 0.562250872 0.74486793 12 46188565 46189071 507 - 2.148 2.383 0.785
ENSG00000111371 E004 6.9865936 0.031982486 0.985112896 0.99435247 12 46195725 46196126 402 - 0.752 0.934 0.707
ENSG00000111371 E005 3.5659918 0.247010222 0.993840261 0.99855241 12 46196127 46196276 150 - 0.527 0.678 0.671
ENSG00000111371 E006 1.2940865 0.015602992 0.087050833   12 46196913 46196937 25 - 0.189 0.607 2.478
ENSG00000111371 E007 3.8840061 0.007276981 0.208015329 0.43944218 12 46197378 46197719 342 - 0.503 0.851 1.478
ENSG00000111371 E008 133.5640688 0.013941693 0.008644840 0.05224529 12 46197720 46197817 98 - 1.990 1.996 0.021
ENSG00000111371 E009 176.7419123 0.064098372 0.326773038 0.56593183 12 46197919 46198060 142 - 2.096 2.181 0.284
ENSG00000111371 E010 184.3570833 0.055659009 0.044987118 0.16755888 12 46198625 46198727 103 - 2.132 2.112 -0.067
ENSG00000111371 E011 98.7432340 0.061814261 0.006263931 0.04101637 12 46198728 46198743 16 - 1.877 1.759 -0.398
ENSG00000111371 E012 160.8156726 0.052744443 0.011286113 0.06355123 12 46201098 46201198 101 - 2.081 2.009 -0.241
ENSG00000111371 E013 139.4943956 0.070057627 0.109786277 0.29868743 12 46203010 46203089 80 - 2.009 2.010 0.004
ENSG00000111371 E014 161.6282789 0.062517472 0.058389144 0.19916483 12 46204301 46204417 117 - 2.076 2.054 -0.071
ENSG00000111371 E015 111.8718737 0.060612747 0.072282617 0.22936677 12 46204532 46204590 59 - 1.917 1.898 -0.065
ENSG00000111371 E016 133.9239043 0.053082855 0.077321392 0.23947112 12 46206080 46206162 83 - 1.991 1.994 0.011
ENSG00000111371 E017 135.0416978 0.057418741 0.161328618 0.37871928 12 46207155 46207236 82 - 1.987 2.035 0.161
ENSG00000111371 E018 127.3733452 0.046967901 0.130251245 0.33219386 12 46207529 46207582 54 - 1.961 2.018 0.191
ENSG00000111371 E019 110.9623466 0.050728298 0.199927872 0.42959226 12 46207583 46207621 39 - 1.898 1.976 0.262
ENSG00000111371 E020 119.2474465 0.050076624 0.075892781 0.23654840 12 46209054 46209127 74 - 1.938 1.966 0.094
ENSG00000111371 E021 126.3946842 0.064657195 0.027100022 0.11858608 12 46229153 46229231 79 - 1.974 1.922 -0.176
ENSG00000111371 E022 108.3021270 0.063364569 0.016415500 0.08333312 12 46229232 46229268 37 - 1.912 1.827 -0.288
ENSG00000111371 E023 130.0247877 0.074111063 0.016162425 0.08237797 12 46229564 46229639 76 - 1.994 1.888 -0.355
ENSG00000111371 E024 211.0579589 0.056640862 0.003278691 0.02506515 12 46239679 46239893 215 - 2.204 2.083 -0.405
ENSG00000111371 E025 0.3206185 0.028010382 1.000000000   12 46239894 46239895 2 - 0.105 0.000 -21.677
ENSG00000111371 E026 120.2408185 0.049858087 0.015951484 0.08162374 12 46243200 46243314 115 - 1.952 1.905 -0.158
ENSG00000111371 E027 7.1266555 0.100433679 0.499748812 0.70056745 12 46254814 46254936 123 - 0.783 0.844 0.239
ENSG00000111371 E028 1.2375711 0.014165765 0.504346966   12 46267225 46267701 477 - 0.292 0.246 -0.331
ENSG00000111371 E029 81.5572864 0.078614356 0.230845581 0.46614058 12 46268526 46268859 334 - 1.772 1.816 0.149
ENSG00000111371 E030 8.6080377 0.328854496 0.742620319 0.86203510 12 46268860 46268864 5 - 0.837 0.962 0.476
ENSG00000111371 E031 59.0884621 0.081789739 0.021589044 0.10125987 12 46268865 46269130 266 - 1.656 1.552 -0.355
ENSG00000111371 E032 0.0000000       12 46269655 46269951 297 -      
ENSG00000111371 E033 0.0000000       12 46269980 46270017 38 -