ENSG00000111300

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000261745 ENSG00000111300 HEK293_OSMI2_6hA HEK293_TMG_6hB NAA25 protein_coding protein_coding 16.69248 5.024792 31.28093 0.4822489 1.196135 2.63574 11.7990500 4.0729724 21.417640 0.6812247 0.8629796 2.3917812 0.75819167 0.79833333 0.68463333 -0.11370000 5.473944e-01 1.097572e-05 FALSE TRUE
MSTRG.8033.3 ENSG00000111300 HEK293_OSMI2_6hA HEK293_TMG_6hB NAA25 protein_coding   16.69248 5.024792 31.28093 0.4822489 1.196135 2.63574 1.4615533 0.0000000 3.863972 0.0000000 1.0822276 8.5976697 0.05199167 0.00000000 0.12166667 0.12166667 1.097572e-05 1.097572e-05 FALSE TRUE
MSTRG.8033.4 ENSG00000111300 HEK293_OSMI2_6hA HEK293_TMG_6hB NAA25 protein_coding   16.69248 5.024792 31.28093 0.4822489 1.196135 2.63574 1.3474325 0.0000000 1.638520 0.0000000 0.8194177 7.3650278 0.05041250 0.00000000 0.05296667 0.05296667 5.597767e-01 1.097572e-05 TRUE TRUE
MSTRG.8033.7 ENSG00000111300 HEK293_OSMI2_6hA HEK293_TMG_6hB NAA25 protein_coding   16.69248 5.024792 31.28093 0.4822489 1.196135 2.63574 0.1643583 0.2929077 0.172109 0.1580946 0.1721090 -0.7340761 0.02439167 0.06523333 0.00520000 -0.06003333 5.126591e-01 1.097572e-05 TRUE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000111300 E001 192.4600280 0.0056593756 1.632161e-04 2.255684e-03 12 112026689 112027787 1099 - 2.119 2.302 0.611
ENSG00000111300 E002 577.1930480 0.0021364337 1.173677e-07 4.283630e-06 12 112027788 112028967 1180 - 2.603 2.751 0.492
ENSG00000111300 E003 213.9355466 0.0004687640 2.601861e-01 4.991554e-01 12 112028968 112029314 347 - 2.196 2.247 0.167
ENSG00000111300 E004 73.2226160 0.0006559716 7.664891e-01 8.764962e-01 12 112029315 112029386 72 - 1.742 1.739 -0.009
ENSG00000111300 E005 64.7136891 0.0075357097 3.744748e-01 6.077043e-01 12 112029387 112029414 28 - 1.673 1.746 0.245
ENSG00000111300 E006 119.1257259 0.0050740434 2.127105e-01 4.449155e-01 12 112029415 112029549 135 - 1.934 2.015 0.270
ENSG00000111300 E007 122.6620038 0.0007923758 3.402090e-03 2.577184e-02 12 112029550 112029653 104 - 1.936 2.070 0.451
ENSG00000111300 E008 149.0000287 0.0008109797 5.081358e-02 1.816138e-01 12 112033233 112033379 147 - 2.032 2.121 0.300
ENSG00000111300 E009 20.8439888 0.1431731082 6.137265e-01 7.793814e-01 12 112033380 112035405 2026 - 1.187 1.334 0.516
ENSG00000111300 E010 73.5262703 0.0005628042 8.645887e-01 9.329242e-01 12 112039229 112039261 33 - 1.746 1.751 0.016
ENSG00000111300 E011 62.0956222 0.0006070161 9.315180e-01 9.678680e-01 12 112039262 112039269 8 - 1.671 1.690 0.064
ENSG00000111300 E012 92.6568161 0.0004443869 5.010038e-01 7.014929e-01 12 112039270 112039339 70 - 1.848 1.828 -0.064
ENSG00000111300 E013 14.3877463 0.2223664532 5.896881e-01 7.634974e-01 12 112039340 112040480 1141 - 1.024 1.225 0.723
ENSG00000111300 E014 98.3010790 0.0004126895 1.880428e-01 4.144795e-01 12 112040481 112040578 98 - 1.875 1.824 -0.170
ENSG00000111300 E015 100.7667017 0.0009712384 8.786156e-01 9.405874e-01 12 112042039 112042104 66 - 1.876 1.882 0.022
ENSG00000111300 E016 0.2852693 0.3197207154 1.000000e+00   12 112042105 112042311 207 - 0.106 0.001 -7.444
ENSG00000111300 E017 122.2751098 0.0003806882 7.326172e-01 8.557653e-01 12 112043088 112043211 124 - 1.958 1.986 0.096
ENSG00000111300 E018 196.8405271 0.0002994269 7.146875e-01 8.447335e-01 12 112043625 112043868 244 - 2.164 2.191 0.088
ENSG00000111300 E019 181.7089879 0.0003614086 2.564995e-01 4.952645e-01 12 112047665 112047790 126 - 2.138 2.112 -0.088
ENSG00000111300 E020 168.8930031 0.0033389547 4.247746e-02 1.611773e-01 12 112048292 112048443 152 - 2.114 2.032 -0.276
ENSG00000111300 E021 9.7137350 0.0446913992 2.495519e-03 2.030260e-02 12 112049483 112049611 129 - 0.796 1.240 1.639
ENSG00000111300 E022 94.8245843 0.0008506007 7.606346e-01 8.729455e-01 12 112053558 112053657 100 - 1.857 1.856 -0.003
ENSG00000111300 E023 128.1062165 0.0003437266 5.873945e-02 1.999461e-01 12 112054388 112054568 181 - 1.993 1.926 -0.226
ENSG00000111300 E024 86.4961970 0.0004997396 9.988923e-02 2.815610e-01 12 112060270 112060359 90 - 1.824 1.751 -0.246
ENSG00000111300 E025 141.6984056 0.0030958435 7.730337e-02 2.394333e-01 12 112061181 112061388 208 - 2.038 1.965 -0.244
ENSG00000111300 E026 115.0910976 0.0008025786 1.014354e-01 2.844162e-01 12 112068880 112068992 113 - 1.945 1.882 -0.212
ENSG00000111300 E027 141.5229853 0.0003236772 3.851731e-01 6.166356e-01 12 112071895 112072064 170 - 2.027 2.006 -0.071
ENSG00000111300 E028 83.4266933 0.0007211181 6.464752e-01 8.011674e-01 12 112074675 112074764 90 - 1.800 1.789 -0.036
ENSG00000111300 E029 99.1090142 0.0013538743 2.844389e-01 5.249607e-01 12 112075678 112075789 112 - 1.878 1.838 -0.136
ENSG00000111300 E030 96.8622701 0.0014642158 8.025127e-04 8.303106e-03 12 112078188 112078266 79 - 1.886 1.715 -0.576
ENSG00000111300 E031 107.6253671 0.0025126523 2.508503e-04 3.229634e-03 12 112078634 112078681 48 - 1.934 1.745 -0.640
ENSG00000111300 E032 108.5033542 0.0018100126 9.321997e-04 9.356874e-03 12 112078682 112078741 60 - 1.935 1.773 -0.546
ENSG00000111300 E033 105.3014519 0.0065868392 6.523748e-02 2.144156e-01 12 112081060 112081134 75 - 1.913 1.806 -0.359
ENSG00000111300 E034 131.2422840 0.0030675590 1.936680e-02 9.374052e-02 12 112087683 112087801 119 - 2.007 1.899 -0.363
ENSG00000111300 E035 0.3503582 0.0311007033 2.370030e-01   12 112090312 112090725 414 - 0.057 0.240 2.387
ENSG00000111300 E036 133.2907916 0.0021968219 7.687475e-03 4.788929e-02 12 112090726 112090864 139 - 2.018 1.902 -0.388
ENSG00000111300 E037 80.0088668 0.0005617940 1.951922e-02 9.425116e-02 12 112093051 112093136 86 - 1.800 1.683 -0.394
ENSG00000111300 E038 3.8109681 0.0804282148 2.876813e-02 1.236770e-01 12 112097241 112097441 201 - 0.475 0.887 1.755
ENSG00000111300 E039 55.8587865 0.0006266405 3.329485e-01 5.715906e-01 12 112108716 112108931 216 - 1.635 1.587 -0.165