ENSG00000111144

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000228740 ENSG00000111144 HEK293_OSMI2_6hA HEK293_TMG_6hB LTA4H protein_coding protein_coding 91.10215 64.60246 110.903 4.743443 4.098562 0.779544 67.79618 51.374079 82.58682 4.4971088 3.6253511 0.6847649 0.7472208 0.7935000 0.7442667 -0.04923333 0.39508252 0.01429809 FALSE  
MSTRG.7830.5 ENSG00000111144 HEK293_OSMI2_6hA HEK293_TMG_6hB LTA4H protein_coding   91.10215 64.60246 110.903 4.743443 4.098562 0.779544 18.65552 9.958042 23.23497 0.8885512 0.7878753 1.2215366 0.1998250 0.1537667 0.2096000 0.05583333 0.01429809 0.01429809 FALSE  
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000111144 E001 0.2027342 0.0351320891 0.3766640426   12 96000753 96000829 77 - 0.000 0.137 10.528
ENSG00000111144 E002 1.5482901 0.0130889990 0.0002298442 0.002999967 12 96000830 96000832 3 - 0.000 0.637 13.728
ENSG00000111144 E003 1.9042578 0.0179454981 0.0106949491 0.061085270 12 96000833 96000841 9 - 0.194 0.637 2.568
ENSG00000111144 E004 50.6817672 0.0012973972 0.0064486654 0.041923731 12 96000842 96000906 65 - 1.641 1.780 0.473
ENSG00000111144 E005 557.4460200 0.0024360128 0.2849662648 0.525557129 12 96000907 96001106 200 - 2.727 2.761 0.115
ENSG00000111144 E006 419.6611331 0.0040378918 0.4894173745 0.693607687 12 96002960 96002989 30 - 2.605 2.636 0.100
ENSG00000111144 E007 554.6795223 0.0028323913 0.2348878302 0.470737520 12 96002990 96003064 75 - 2.722 2.762 0.134
ENSG00000111144 E008 7.3563913 0.0085756628 0.0108800412 0.061859495 12 96003594 96003837 244 - 0.762 1.069 1.167
ENSG00000111144 E009 535.3077525 0.0004918094 0.0108690628 0.061811561 12 96003838 96003920 83 - 2.703 2.751 0.161
ENSG00000111144 E010 5.6042541 0.0127984931 0.4659199621 0.677206764 12 96003921 96003981 61 - 0.763 0.863 0.394
ENSG00000111144 E011 729.2744505 0.0006415845 0.6672744366 0.814479599 12 96006314 96006409 96 - 2.854 2.864 0.033
ENSG00000111144 E012 577.7583112 0.0001502260 0.7910624003 0.891094150 12 96009094 96009148 55 - 2.759 2.756 -0.012
ENSG00000111144 E013 33.4891776 0.0398749449 0.6562811566 0.807533468 12 96009149 96009993 845 - 1.502 1.568 0.225
ENSG00000111144 E014 38.1203967 0.1186748482 0.9468443924 0.975737863 12 96009994 96011294 1301 - 1.553 1.631 0.266
ENSG00000111144 E015 13.7796735 0.2403682102 0.9787863042 0.991198135 12 96011295 96011752 458 - 1.194 1.134 -0.216
ENSG00000111144 E016 9.3165394 0.0856183073 0.2213314167 0.455098260 12 96011753 96011865 113 - 1.092 0.886 -0.764
ENSG00000111144 E017 32.1515506 0.1083717293 0.1303538705 0.332368707 12 96011866 96013187 1322 - 1.597 1.388 -0.716
ENSG00000111144 E018 529.7244687 0.0009035312 0.6769713117 0.820783999 12 96013188 96013238 51 - 2.715 2.727 0.039
ENSG00000111144 E019 367.0577680 0.0001828600 0.2397719570 0.476380553 12 96013239 96013258 20 - 2.552 2.575 0.077
ENSG00000111144 E020 571.9564920 0.0011526526 0.0533804625 0.187631541 12 96013750 96013851 102 - 2.734 2.779 0.151
ENSG00000111144 E021 296.8221883 0.0059505555 0.9217029425 0.963150038 12 96013852 96013853 2 - 2.464 2.476 0.040
ENSG00000111144 E022 3.0287121 0.0120311953 0.1914213852 0.418676960 12 96013854 96014324 471 - 0.668 0.456 -0.980
ENSG00000111144 E023 854.8111209 0.0046216865 0.6759290619 0.820156625 12 96014855 96014999 145 - 2.932 2.925 -0.024
ENSG00000111144 E024 0.1426347 0.0313505866 0.6226912770   12 96015080 96015174 95 - 0.108 0.000 -9.796
ENSG00000111144 E025 890.7640391 0.0039943131 0.2132672231 0.445575495 12 96015583 96015694 112 - 2.961 2.928 -0.110
ENSG00000111144 E026 719.6882407 0.0050712247 0.0527511163 0.186108919 12 96017044 96017114 71 - 2.881 2.817 -0.214
ENSG00000111144 E027 520.4977020 0.0031516514 0.0450122139 0.167626622 12 96017557 96017576 20 - 2.737 2.680 -0.191
ENSG00000111144 E028 393.9567569 0.0009434966 0.0035723681 0.026773920 12 96017577 96017580 4 - 2.620 2.555 -0.216
ENSG00000111144 E029 769.7349243 0.0017208265 0.1454676255 0.355608236 12 96018763 96018903 141 - 2.896 2.867 -0.097
ENSG00000111144 E030 474.6569088 0.0006773627 0.1465374871 0.357231140 12 96019168 96019240 73 - 2.687 2.659 -0.092
ENSG00000111144 E031 0.8461841 0.0172671820 0.2817495437   12 96020690 96020758 69 - 0.327 0.137 -1.603
ENSG00000111144 E032 387.4760654 0.0008389466 0.2182150407 0.451289096 12 96021085 96021137 53 - 2.599 2.572 -0.088
ENSG00000111144 E033 523.6211375 0.0071086174 0.5629775344 0.745408823 12 96022147 96022251 105 - 2.707 2.729 0.073
ENSG00000111144 E034 394.5314850 0.0777490741 0.3721699999 0.605721611 12 96024479 96024547 69 - 2.560 2.635 0.250
ENSG00000111144 E035 354.2170898 1.6764770121 0.5760627284 0.754455230 12 96027444 96027503 60 - 2.491 2.610 0.394
ENSG00000111144 E036 293.8918688 1.6202407629 0.5798825092 0.757131715 12 96027504 96027564 61 - 2.415 2.524 0.363
ENSG00000111144 E037 466.0470853 0.0154222704 0.7480678589 0.865548664 12 96029055 96029185 131 - 2.661 2.673 0.037
ENSG00000111144 E038 471.8323428 0.0033656375 0.0233205726 0.106953188 12 96035361 96035641 281 - 2.701 2.632 -0.228
ENSG00000111144 E039 3.7377306 0.0072257228 0.6656821355 0.813458033 12 96043289 96043520 232 - 0.641 0.705 0.270