ENSG00000111057

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000388835 ENSG00000111057 HEK293_OSMI2_6hA HEK293_TMG_6hB KRT18 protein_coding protein_coding 53.7976 83.7945 13.14808 17.06505 0.6837843 -2.671078 34.60756 56.35382 4.847716 11.537645 0.8827414 -3.536419 0.5897417 0.6721 0.3635333 -0.3085667 0.0007405051 0.0007405051 FALSE TRUE
ENST00000388837 ENSG00000111057 HEK293_OSMI2_6hA HEK293_TMG_6hB KRT18 protein_coding protein_coding 53.7976 83.7945 13.14808 17.06505 0.6837843 -2.671078 18.37124 26.24436 8.039529 5.883064 0.2685571 -1.705581 0.3912333 0.3098 0.6169667 0.3071667 0.0013016807 0.0007405051 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000111057 E001 7.714090 0.0157706412 9.284157e-01 9.662260e-01 12 52948807 52948870 64 + 0.749 0.773 0.095
ENSG00000111057 E002 23.402651 0.0015340730 4.980981e-01 6.995527e-01 12 52948871 52948885 15 + 1.246 1.188 -0.205
ENSG00000111057 E003 36.266313 0.0011174877 3.720646e-01 6.056466e-01 12 52948886 52948915 30 + 1.429 1.365 -0.220
ENSG00000111057 E004 43.035496 0.0009202052 4.499611e-01 6.656593e-01 12 52948916 52948938 23 + 1.485 1.437 -0.164
ENSG00000111057 E005 37.503010 0.0013853730 7.276950e-03 4.596466e-02 12 52949118 52949126 9 + 1.114 1.414 1.057
ENSG00000111057 E006 89.078965 0.0005814084 1.844468e-06 4.854766e-05 12 52949127 52949172 46 + 1.414 1.780 1.250
ENSG00000111057 E007 586.304926 0.5969624183 3.983969e-01 6.269603e-01 12 52949173 52949590 418 + 2.449 2.571 0.408
ENSG00000111057 E008 3.342182 0.4450414460 2.253413e-01 4.597437e-01 12 52949805 52950327 523 + 0.001 0.519 9.443
ENSG00000111057 E009 337.656149 0.0011227141 8.711954e-01 9.365925e-01 12 52950328 52950410 83 + 2.307 2.324 0.057
ENSG00000111057 E010 1.970412 0.0111038423 6.211936e-03 4.077848e-02 12 52950411 52950749 339 + 0.749 0.253 -2.547
ENSG00000111057 E011 462.105888 0.0006087501 3.308441e-02 1.362857e-01 12 52950750 52950906 157 + 2.494 2.452 -0.141
ENSG00000111057 E012 218.924337 0.0003741627 1.994114e-02 9.568215e-02 12 52951481 52951495 15 + 2.196 2.125 -0.236
ENSG00000111057 E013 475.508318 0.0122401211 3.285546e-01 5.675299e-01 12 52951496 52951645 150 + 2.491 2.466 -0.085
ENSG00000111057 E014 3.044812 0.2817995925 9.279815e-01 9.660164e-01 12 52951646 52951730 85 + 0.450 0.471 0.107
ENSG00000111057 E015 207.600510 0.0002495672 5.655117e-01 7.470432e-01 12 52951731 52951741 11 + 2.118 2.111 -0.025
ENSG00000111057 E016 416.443410 0.0002613792 8.954016e-01 9.494539e-01 12 52951742 52951856 115 + 2.402 2.413 0.039
ENSG00000111057 E017 2.519733 0.0096765512 2.912442e-01 5.318046e-01 12 52951857 52952118 262 + 0.576 0.372 -1.032
ENSG00000111057 E018 548.979435 0.0070868660 9.009588e-01 9.523406e-01 12 52952119 52952342 224 + 2.512 2.533 0.071
ENSG00000111057 E019 4.658089 0.1442487621 4.053654e-01 6.326085e-01 12 52952343 52952721 379 + 0.749 0.573 -0.747
ENSG00000111057 E020 256.023607 0.0005925013 8.771623e-01 9.397839e-01 12 52952722 52952906 185 + 2.196 2.206 0.033