ENSG00000110911

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000262052 ENSG00000110911 HEK293_OSMI2_6hA HEK293_TMG_6hB SLC11A2 protein_coding protein_coding 13.36963 8.122414 21.00494 1.252642 0.6589592 1.36966 5.266817 2.196182 9.089007 0.4830371 0.3202188 2.0441571 0.3866333 0.2976333 0.4332000 0.13556667 0.67552947 0.01280557 FALSE  
ENST00000546636 ENSG00000110911 HEK293_OSMI2_6hA HEK293_TMG_6hB SLC11A2 protein_coding nonsense_mediated_decay 13.36963 8.122414 21.00494 1.252642 0.6589592 1.36966 1.561676 1.499975 1.816720 0.2867888 0.1500676 0.2747302 0.1303458 0.1826667 0.0871000 -0.09556667 0.01280557 0.01280557 TRUE  
ENST00000644495 ENSG00000110911 HEK293_OSMI2_6hA HEK293_TMG_6hB SLC11A2 protein_coding protein_coding 13.36963 8.122414 21.00494 1.252642 0.6589592 1.36966 2.862845 1.865918 3.968153 0.1199418 0.2911447 1.0845020 0.2275292 0.2372667 0.1887333 -0.04853333 0.73327997 0.01280557 FALSE  
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000110911 E001 0.4654660 0.0258686250 0.311331870   12 50979401 50979411 11 - 0.210 0.000 -10.628
ENSG00000110911 E002 2.7081408 0.1167248184 0.084311078 0.25336590 12 50979412 50979542 131 - 0.389 0.779 1.792
ENSG00000110911 E003 1.1555836 0.0172453052 0.491368724   12 50979784 50979808 25 - 0.262 0.400 0.869
ENSG00000110911 E004 3.4132905 0.0269923692 0.048956673 0.17713794 12 50979809 50979819 11 - 0.486 0.817 1.429
ENSG00000110911 E005 6.5077612 0.1291238292 0.015396868 0.07957513 12 50979820 50979839 20 - 0.648 1.125 1.838
ENSG00000110911 E006 13.8346571 0.3307543025 0.048606585 0.17638986 12 50979840 50979923 84 - 0.925 1.419 1.769
ENSG00000110911 E007 10.5762451 0.2407701351 0.027278078 0.11911355 12 50979924 50979942 19 - 0.809 1.321 1.871
ENSG00000110911 E008 22.4793310 0.4389253011 0.038154753 0.15001053 12 50979943 50980058 116 - 1.059 1.659 2.093
ENSG00000110911 E009 63.1451888 0.9127591303 0.282354843 0.52277342 12 50980059 50980864 806 - 1.638 1.977 1.145
ENSG00000110911 E010 24.1971966 0.6303886236 0.279956583 0.52005105 12 50980865 50981008 144 - 1.262 1.540 0.962
ENSG00000110911 E011 30.4387045 0.2380081104 0.107565871 0.29499326 12 50981009 50981437 429 - 1.334 1.665 1.138
ENSG00000110911 E012 36.2473873 0.0104847877 0.319240355 0.55897144 12 50981438 50981638 201 - 1.502 1.609 0.367
ENSG00000110911 E013 61.4413692 0.0110710429 0.019959744 0.09572801 12 50981639 50981803 165 - 1.692 1.884 0.648
ENSG00000110911 E014 0.0000000       12 50985992 50985992 1 -      
ENSG00000110911 E015 6.7340847 0.0047150783 0.204439594 0.43515674 12 50985993 50986070 78 - 0.894 0.742 -0.596
ENSG00000110911 E016 7.9200282 0.0043635678 0.377951428 0.61050818 12 50986071 50986080 10 - 0.938 0.847 -0.345
ENSG00000110911 E017 20.4995419 0.0020208786 0.782638211 0.88619238 12 50986081 50986163 83 - 1.279 1.324 0.158
ENSG00000110911 E018 290.3630375 0.0060429137 0.150517309 0.36303509 12 50986164 50987945 1782 - 2.435 2.399 -0.122
ENSG00000110911 E019 53.1432286 0.0007307631 0.003033684 0.02361693 12 50987946 50988172 227 - 1.732 1.593 -0.473
ENSG00000110911 E020 52.9012493 0.0011791784 0.297020296 0.53746260 12 50988173 50988299 127 - 1.703 1.670 -0.113
ENSG00000110911 E021 28.1334188 0.0104435694 0.692930138 0.83100543 12 50988300 50988319 20 - 1.428 1.417 -0.038
ENSG00000110911 E022 44.9285919 0.0022729849 0.021555199 0.10113987 12 50988320 50988381 62 - 1.653 1.534 -0.406
ENSG00000110911 E023 78.4398635 0.0011092949 0.650658396 0.80396948 12 50988382 50988435 54 - 1.845 1.889 0.148
ENSG00000110911 E024 0.1614157 0.0330739933 1.000000000   12 50990584 50990794 211 - 0.082 0.000 -10.697
ENSG00000110911 E025 120.4028007 0.0006911531 0.911063904 0.95769591 12 50990795 50990948 154 - 2.036 2.056 0.068
ENSG00000110911 E026 1.0241679 0.0153787590 0.449827811   12 50991487 50991598 112 - 0.309 0.177 -1.042
ENSG00000110911 E027 89.9786858 0.0037144195 0.513049386 0.71028888 12 50991599 50991672 74 - 1.920 1.913 -0.024
ENSG00000110911 E028 102.5861752 0.0004488710 0.995091008 0.99910335 12 50992190 50992339 150 - 1.965 1.989 0.080
ENSG00000110911 E029 88.1309068 0.0018934211 0.818021370 0.90692134 12 50992810 50992929 120 - 1.903 1.917 0.048
ENSG00000110911 E030 1.1292176 0.0458030697 0.004093251   12 50992930 50993144 215 - 0.082 0.603 3.860
ENSG00000110911 E031 75.0015620 0.0056430659 0.556009708 0.74050949 12 50994544 50994630 87 - 1.840 1.832 -0.027
ENSG00000110911 E032 3.4865204 0.2860453494 0.652783107 0.80524229 12 50994631 50995092 462 - 0.520 0.788 1.150
ENSG00000110911 E033 54.5300170 0.0009140354 0.554057249 0.73915068 12 50995629 50995683 55 - 1.685 1.739 0.184
ENSG00000110911 E034 81.7028885 0.0006623625 0.886932571 0.94506453 12 50995684 50995787 104 - 1.869 1.886 0.060
ENSG00000110911 E035 63.0855460 0.0025444954 0.002788507 0.02211623 12 50996817 50996870 54 - 1.802 1.661 -0.479
ENSG00000110911 E036 56.6660061 0.0057880157 0.064249949 0.21224963 12 50996871 50996908 38 - 1.745 1.651 -0.319
ENSG00000110911 E037 57.1820001 0.0012981443 0.002053532 0.01741856 12 50996909 50996940 32 - 1.760 1.615 -0.491
ENSG00000110911 E038 50.6058506 0.0007703691 0.027501768 0.11979769 12 50996941 50996960 20 - 1.698 1.599 -0.336
ENSG00000110911 E039 44.6470457 0.0015943211 0.034912237 0.14136963 12 50996961 50996972 12 - 1.650 1.546 -0.353
ENSG00000110911 E040 67.1290698 0.0007164569 0.615269422 0.78046355 12 50999174 50999241 68 - 1.781 1.828 0.159
ENSG00000110911 E041 0.6841482 0.0455075532 0.433353473   12 50999242 50999344 103 - 0.151 0.303 1.280
ENSG00000110911 E042 49.9772105 0.0007633137 0.267673210 0.50734467 12 50999345 50999367 23 - 1.644 1.726 0.279
ENSG00000110911 E043 55.1075501 0.0017096024 0.804633351 0.89897402 12 50999368 50999415 48 - 1.707 1.718 0.038
ENSG00000110911 E044 0.9340683 0.1611134382 0.888747196   12 50999416 50999565 150 - 0.259 0.304 0.310
ENSG00000110911 E045 34.1159814 0.0166783177 0.159848195 0.37655491 12 51000313 51000317 5 - 1.536 1.440 -0.330
ENSG00000110911 E046 36.4719340 0.0091042841 0.197498743 0.42649169 12 51000318 51000349 32 - 1.558 1.486 -0.247
ENSG00000110911 E047 43.2865964 0.0136251756 0.566030533 0.74739144 12 51000350 51000401 52 - 1.616 1.597 -0.066
ENSG00000110911 E048 37.9543452 0.0029102555 0.230371363 0.46553512 12 51000402 51000419 18 - 1.569 1.514 -0.187
ENSG00000110911 E049 0.3337900 0.0267736750 0.543779174   12 51000563 51000597 35 - 0.082 0.177 1.280
ENSG00000110911 E050 0.3337900 0.0267736750 0.543779174   12 51000598 51000633 36 - 0.082 0.177 1.280
ENSG00000110911 E051 47.2581227 0.0029815898 0.239799544 0.47640166 12 51004788 51004837 50 - 1.657 1.610 -0.158
ENSG00000110911 E052 54.5381142 0.0072820856 0.778020121 0.88352399 12 51004838 51004907 70 - 1.697 1.709 0.039
ENSG00000110911 E053 39.0853518 0.0018028382 0.286759167 0.52748855 12 51005311 51005318 8 - 1.531 1.621 0.308
ENSG00000110911 E054 36.5001157 0.0012005741 0.287024421 0.52779388 12 51005319 51005321 3 - 1.503 1.594 0.309
ENSG00000110911 E055 62.0717486 0.0018184803 0.676959693 0.82078400 12 51005322 51005375 54 - 1.742 1.789 0.156
ENSG00000110911 E056 51.5455988 0.0033303404 0.829442581 0.91348470 12 51005376 51005403 28 - 1.676 1.689 0.042
ENSG00000110911 E057 52.3497336 0.0008137490 0.505622852 0.70468880 12 51005404 51005436 33 - 1.691 1.679 -0.039
ENSG00000110911 E058 7.7939481 0.1434901077 0.650394446 0.80380674 12 51005437 51005599 163 - 0.847 1.027 0.679
ENSG00000110911 E059 3.7411477 0.0662993398 0.968368676 0.98601349 12 51005600 51005652 53 - 0.651 0.656 0.021
ENSG00000110911 E060 3.8688795 0.0092919530 0.498671699 0.69988281 12 51005653 51005677 25 - 0.693 0.603 -0.382
ENSG00000110911 E061 4.5672402 0.0888163593 0.763005676 0.87444350 12 51005678 51005848 171 - 0.674 0.785 0.456
ENSG00000110911 E062 1.2712550 0.2094070691 0.785173721   12 51006174 51006271 98 - 0.348 0.304 -0.277
ENSG00000110911 E063 3.7396495 0.0502150222 0.281624236 0.52196702 12 51008145 51008475 331 - 0.567 0.782 0.909
ENSG00000110911 E064 58.8115014 0.0006137737 0.848018089 0.92382929 12 51008476 51008544 69 - 1.732 1.747 0.048
ENSG00000110911 E065 47.6294794 0.0008932516 0.693854134 0.83157999 12 51008545 51008585 41 - 1.644 1.646 0.006
ENSG00000110911 E066 47.8926567 0.0007487509 0.375522578 0.60861371 12 51008586 51008624 39 - 1.656 1.631 -0.087
ENSG00000110911 E067 0.0000000       12 51009117 51009270 154 -      
ENSG00000110911 E068 39.0832747 0.0009436526 0.304382300 0.54494877 12 51010695 51010719 25 - 1.573 1.534 -0.135
ENSG00000110911 E069 38.2799174 0.0011851648 0.655243549 0.80682686 12 51010720 51010766 47 - 1.556 1.553 -0.012
ENSG00000110911 E070 0.2922838 0.0277933483 0.543078775   12 51024361 51024843 483 - 0.082 0.177 1.276
ENSG00000110911 E071 0.6426420 0.0193874923 0.420053743   12 51025673 51025774 102 - 0.151 0.302 1.277
ENSG00000110911 E072 0.9872031 0.0152875238 0.008055886   12 51025775 51026293 519 - 0.082 0.546 3.600
ENSG00000110911 E073 0.4054685 0.6435748972 0.151922137   12 51026294 51026309 16 - 0.000 0.318 12.817
ENSG00000110911 E074 9.8566758 0.0153589341 0.322347250 0.56180767 12 51026310 51026314 5 - 1.037 0.930 -0.396
ENSG00000110911 E075 26.0256410 0.0016133403 0.456109624 0.67031781 12 51026315 51026400 86 - 1.405 1.373 -0.111
ENSG00000110911 E076 0.1723744 0.0307553050 0.209843965   12 51028177 51028411 235 - 0.000 0.177 12.781
ENSG00000110911 E077 0.0000000       12 51028511 51028566 56 -