ENSG00000110880

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000261401 ENSG00000110880 HEK293_OSMI2_6hA HEK293_TMG_6hB CORO1C protein_coding protein_coding 43.42406 20.43393 55.09091 1.829945 2.647961 1.430403 36.117949 19.55614 42.062015 1.991215 1.3819138 1.104501 0.86738333 0.9548333 0.7649000 -0.1899333 1.875682e-04 9.668279e-29 FALSE TRUE
ENST00000421578 ENSG00000110880 HEK293_OSMI2_6hA HEK293_TMG_6hB CORO1C protein_coding protein_coding 43.42406 20.43393 55.09091 1.829945 2.647961 1.430403 3.826689 0.00000 7.619203 0.000000 0.4790828 9.575389 0.06432083 0.0000000 0.1381333 0.1381333 9.668279e-29 9.668279e-29 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000110880 E001 1.2568141 0.102730599 0.016550507   12 108645109 108645114 6 - 0.087 0.588 3.694
ENSG00000110880 E002 700.9808048 1.786438210 0.458696425 0.67228623 12 108645115 108646219 1105 - 2.692 3.001 1.028
ENSG00000110880 E003 310.8583399 1.509966984 0.437513316 0.65688112 12 108646220 108646566 347 - 2.344 2.644 0.997
ENSG00000110880 E004 81.6299659 0.799554537 0.331555854 0.57040491 12 108646567 108646568 2 - 1.777 2.057 0.943
ENSG00000110880 E005 155.5015543 1.266703083 0.404858830 0.63217431 12 108646569 108646645 77 - 2.046 2.343 0.994
ENSG00000110880 E006 282.8035745 1.481655022 0.439755489 0.65848356 12 108646646 108646988 343 - 2.305 2.601 0.988
ENSG00000110880 E007 286.2358093 1.502420280 0.484647704 0.69026451 12 108646989 108647379 391 - 2.333 2.581 0.826
ENSG00000110880 E008 76.8069202 0.791179221 0.370735880 0.60451866 12 108647380 108647383 4 - 1.772 2.008 0.797
ENSG00000110880 E009 98.9202736 1.116210256 0.423835966 0.64643312 12 108647384 108647400 17 - 1.873 2.125 0.845
ENSG00000110880 E010 88.5592869 0.832944165 0.364039145 0.59908317 12 108647401 108647402 2 - 1.826 2.077 0.844
ENSG00000110880 E011 204.3387628 1.408952033 0.535172202 0.72570212 12 108647403 108647522 120 - 2.218 2.397 0.597
ENSG00000110880 E012 197.2641701 0.030049164 0.542645364 0.73099366 12 108648605 108648686 82 - 2.228 2.347 0.399
ENSG00000110880 E013 275.3100924 0.004513675 0.098011012 0.27827744 12 108648687 108648850 164 - 2.400 2.443 0.143
ENSG00000110880 E014 105.3091043 0.036084705 0.465759218 0.67712313 12 108648963 108648966 4 - 1.984 2.029 0.152
ENSG00000110880 E015 178.8990938 0.025981604 0.374916972 0.60812551 12 108648967 108649020 54 - 2.212 2.258 0.153
ENSG00000110880 E016 8.2689223 0.237530839 0.261381762 0.50044360 12 108649021 108649671 651 - 0.972 0.880 -0.347
ENSG00000110880 E017 4.0988982 0.070425079 0.106555243 0.29324555 12 108652045 108652271 227 - 0.739 0.525 -0.930
ENSG00000110880 E018 282.6344048 0.031778294 0.212070149 0.44418886 12 108652272 108652417 146 - 2.421 2.433 0.040
ENSG00000110880 E019 1.1610054 0.015378759 0.759215849   12 108653038 108653060 23 - 0.276 0.381 0.658
ENSG00000110880 E020 249.8859964 0.028894667 0.195838098 0.42439085 12 108654306 108654410 105 - 2.368 2.379 0.035
ENSG00000110880 E021 179.8181660 0.021823474 0.334383181 0.57295310 12 108657304 108657361 58 - 2.215 2.259 0.148
ENSG00000110880 E022 200.9020762 0.021170789 0.103294213 0.28773529 12 108657362 108657423 62 - 2.279 2.275 -0.014
ENSG00000110880 E023 239.4588275 0.029742487 0.087058751 0.25837690 12 108658738 108658822 85 - 2.361 2.336 -0.085
ENSG00000110880 E024 179.8114783 0.032896138 0.019315346 0.09355399 12 108658823 108658858 36 - 2.259 2.162 -0.325
ENSG00000110880 E025 148.1567768 0.023444747 0.017740436 0.08813803 12 108658859 108658877 19 - 2.168 2.095 -0.243
ENSG00000110880 E026 132.6721945 0.024647921 0.008320653 0.05080107 12 108658878 108658880 3 - 2.129 2.027 -0.340
ENSG00000110880 E027 169.4907827 0.029566535 0.010220735 0.05906206 12 108658881 108658919 39 - 2.236 2.130 -0.353
ENSG00000110880 E028 0.4514866 0.021926746 0.902551077   12 108662023 108662028 6 - 0.160 0.166 0.068
ENSG00000110880 E029 221.6277691 0.033793247 0.019611424 0.09458828 12 108662029 108662113 85 - 2.348 2.254 -0.313
ENSG00000110880 E030 168.2069794 0.026153034 0.027197929 0.11887972 12 108662114 108662158 45 - 2.222 2.155 -0.222
ENSG00000110880 E031 255.2720750 0.025633780 0.016844106 0.08488164 12 108678272 108678394 123 - 2.404 2.331 -0.242
ENSG00000110880 E032 0.0000000       12 108696360 108696402 43 -      
ENSG00000110880 E033 0.1614157 0.031598219 0.760851402   12 108700940 108701123 184 - 0.087 0.001 -7.567
ENSG00000110880 E034 271.9443297 0.038487962 0.128573541 0.32961090 12 108701124 108701306 183 - 2.417 2.393 -0.080
ENSG00000110880 E035 102.3157120 0.054965228 0.692153704 0.83041525 12 108701307 108701323 17 - 1.961 2.039 0.263
ENSG00000110880 E036 0.6682002 0.019675539 0.617932938   12 108701324 108701356 33 - 0.222 0.167 -0.512
ENSG00000110880 E037 0.7249894 0.081746470 0.920375874   12 108701489 108701965 477 - 0.222 0.284 0.474
ENSG00000110880 E038 0.0000000       12 108701966 108701981 16 -      
ENSG00000110880 E039 0.6300180 0.393227693 0.654968414   12 108702796 108703075 280 - 0.157 0.290 1.127
ENSG00000110880 E040 2.8735733 0.008606630 0.539401149 0.72855711 12 108730145 108730561 417 - 0.509 0.676 0.749
ENSG00000110880 E041 0.0000000       12 108730562 108730622 61 -      
ENSG00000110880 E042 0.3088520 0.035518291 0.709056755   12 108730623 108730843 221 - 0.087 0.166 1.065
ENSG00000110880 E043 0.5061644 0.278921927 0.385924866   12 108731102 108731153 52 - 0.087 0.289 2.087
ENSG00000110880 E044 99.4184063 0.042095147 0.609989589 0.77687031 12 108731429 108731526 98 - 1.952 2.020 0.228