ENSG00000110841

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000537261 ENSG00000110841 HEK293_OSMI2_6hA HEK293_TMG_6hB PPFIBP1 protein_coding protein_coding 5.613841 3.620421 9.769031 0.913493 0.6724604 1.429555 0.4035453 0.0000000 0.57005246 0.0000000 0.57005246 5.8581115 0.05669583 0.00000000 0.066966667 0.066966667 1.000000e+00 9.327218e-08 FALSE FALSE
ENST00000539326 ENSG00000110841 HEK293_OSMI2_6hA HEK293_TMG_6hB PPFIBP1 protein_coding protein_coding 5.613841 3.620421 9.769031 0.913493 0.6724604 1.429555 0.3140381 0.4165842 0.01356158 0.2101474 0.01356158 -4.1783222 0.11448333 0.09286667 0.001266667 -0.091600000 1.649447e-01 9.327218e-08 FALSE TRUE
ENST00000540114 ENSG00000110841 HEK293_OSMI2_6hA HEK293_TMG_6hB PPFIBP1 protein_coding protein_coding 5.613841 3.620421 9.769031 0.913493 0.6724604 1.429555 0.2279328 0.0000000 0.79093498 0.0000000 0.45609459 6.3236132 0.02691667 0.00000000 0.078266667 0.078266667 8.970958e-02 9.327218e-08 FALSE TRUE
ENST00000542629 ENSG00000110841 HEK293_OSMI2_6hA HEK293_TMG_6hB PPFIBP1 protein_coding protein_coding 5.613841 3.620421 9.769031 0.913493 0.6724604 1.429555 1.0167798 0.4844294 1.72661452 0.2720822 0.25885651 1.8124410 0.17537917 0.16886667 0.175833333 0.006966667 9.374390e-01 9.327218e-08 FALSE TRUE
ENST00000545381 ENSG00000110841 HEK293_OSMI2_6hA HEK293_TMG_6hB PPFIBP1 protein_coding non_stop_decay 5.613841 3.620421 9.769031 0.913493 0.6724604 1.429555 0.8021125 0.0000000 2.20508832 0.0000000 0.57760755 7.7912204 0.09139167 0.00000000 0.219533333 0.219533333 9.327218e-08 9.327218e-08 FALSE TRUE
MSTRG.7005.3 ENSG00000110841 HEK293_OSMI2_6hA HEK293_TMG_6hB PPFIBP1 protein_coding   5.613841 3.620421 9.769031 0.913493 0.6724604 1.429555 0.9213619 0.3639372 1.08713190 0.2877880 0.09291916 1.5528690 0.14677917 0.10523333 0.112733333 0.007500000 8.967910e-01 9.327218e-08 FALSE TRUE
MSTRG.7005.4 ENSG00000110841 HEK293_OSMI2_6hA HEK293_TMG_6hB PPFIBP1 protein_coding   5.613841 3.620421 9.769031 0.913493 0.6724604 1.429555 1.1947329 1.6839543 2.33416109 0.5929480 0.21002928 0.4686768 0.24888750 0.45523333 0.244333333 -0.210900000 2.255504e-01 9.327218e-08 FALSE TRUE
MSTRG.7005.8 ENSG00000110841 HEK293_OSMI2_6hA HEK293_TMG_6hB PPFIBP1 protein_coding   5.613841 3.620421 9.769031 0.913493 0.6724604 1.429555 0.2673932 0.2351782 0.32857420 0.2351782 0.26279324 0.4656414 0.05654583 0.04756667 0.030733333 -0.016833333 9.685635e-01 9.327218e-08 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000110841 E001 0.1779838 0.0636548518 0.8969153942   12 27523431 27523707 277 + 0.087 0.000 -11.499
ENSG00000110841 E002 0.3206185 0.0250588696 0.4288766309   12 27524142 27524145 4 + 0.159 0.000 -12.487
ENSG00000110841 E003 0.6246688 0.0192198833 0.1291029609   12 27524146 27524154 9 + 0.274 0.000 -13.486
ENSG00000110841 E004 0.6246688 0.0192198833 0.1291029609   12 27524155 27524157 3 + 0.274 0.000 -13.486
ENSG00000110841 E005 2.5374547 0.0091347802 0.1392865229 0.346434806 12 27524158 27524172 15 + 0.587 0.383 -1.016
ENSG00000110841 E006 2.5374547 0.0091347802 0.1392865229 0.346434806 12 27524173 27524173 1 + 0.587 0.383 -1.016
ENSG00000110841 E007 2.6988704 0.0090658643 0.1036189892 0.288232586 12 27524174 27524178 5 + 0.611 0.383 -1.123
ENSG00000110841 E008 3.7997763 0.0065857987 0.1159658126 0.309080186 12 27524179 27524181 3 + 0.715 0.526 -0.826
ENSG00000110841 E009 6.9965114 0.0042223089 0.0524765551 0.185418095 12 27524182 27524205 24 + 0.940 0.757 -0.708
ENSG00000110841 E010 9.2760360 0.0035575172 0.0911309820 0.265734933 12 27524206 27524219 14 + 1.029 0.907 -0.454
ENSG00000110841 E011 9.5683198 0.0037405149 0.1134852375 0.304967220 12 27524220 27524223 4 + 1.038 0.932 -0.394
ENSG00000110841 E012 19.8297214 0.0022500564 0.0376160189 0.148623581 12 27524224 27524365 142 + 1.328 1.231 -0.338
ENSG00000110841 E013 0.1723744 0.0939925482 0.2741736268   12 27538123 27538299 177 + 0.000 0.168 13.656
ENSG00000110841 E014 21.3794914 0.0018572785 0.0024078525 0.019734025 12 27578152 27578239 88 + 1.379 1.207 -0.602
ENSG00000110841 E015 0.0000000       12 27584125 27584418 294 +      
ENSG00000110841 E016 0.0000000       12 27599348 27599479 132 +      
ENSG00000110841 E017 20.9793909 0.0075461899 0.0009395828 0.009418734 12 27633362 27633460 99 + 1.382 1.152 -0.807
ENSG00000110841 E018 43.9345011 0.0254859327 0.0425689599 0.161416257 12 27634910 27635115 206 + 1.656 1.564 -0.312
ENSG00000110841 E019 0.3393995 0.0269243154 0.4277579320   12 27635116 27637319 2204 + 0.159 0.000 -12.489
ENSG00000110841 E020 35.5867811 0.0133839111 0.1491703796 0.361032414 12 27646062 27646148 87 + 1.552 1.511 -0.140
ENSG00000110841 E021 40.0456983 0.0287715787 0.3334762020 0.572022353 12 27647729 27647842 114 + 1.596 1.567 -0.099
ENSG00000110841 E022 0.4764247 0.0215355062 1.0000000000   12 27647843 27647977 135 + 0.158 0.168 0.102
ENSG00000110841 E023 37.1024052 0.0014017125 0.0073690069 0.046402420 12 27650010 27650141 132 + 1.585 1.494 -0.309
ENSG00000110841 E024 0.0000000       12 27654386 27654721 336 +      
ENSG00000110841 E025 41.8709258 0.0008967197 0.0008167241 0.008418727 12 27654722 27654814 93 + 1.645 1.526 -0.406
ENSG00000110841 E026 0.0000000       12 27655143 27655235 93 +      
ENSG00000110841 E027 44.5529000 0.0008979371 0.0054649321 0.037044312 12 27656616 27656730 115 + 1.662 1.583 -0.269
ENSG00000110841 E028 0.1614157 0.0340304520 0.8965930725   12 27656731 27657123 393 + 0.086 0.000 -11.487
ENSG00000110841 E029 0.2617363 0.0462238107 0.0907872742   12 27658816 27658848 33 + 0.000 0.288 14.643
ENSG00000110841 E030 29.6912487 0.0012704725 0.0177511468 0.088173184 12 27660884 27660933 50 + 1.494 1.407 -0.297
ENSG00000110841 E031 20.5703671 0.0018679789 0.7317927836 0.855304639 12 27660934 27660945 12 + 1.300 1.347 0.165
ENSG00000110841 E032 30.3337213 0.0012568882 0.3669289240 0.601450241 12 27664362 27664437 76 + 1.472 1.488 0.055
ENSG00000110841 E033 12.0401970 0.0029093768 0.9739771548 0.988860459 12 27664438 27664446 9 + 1.063 1.138 0.270
ENSG00000110841 E034 46.0230449 0.0042161197 0.1560449500 0.370966915 12 27667166 27667320 155 + 1.647 1.638 -0.031
ENSG00000110841 E035 38.9193993 0.0174903011 0.3769497288 0.609824312 12 27671431 27671546 116 + 1.572 1.575 0.012
ENSG00000110841 E036 27.7083002 0.0345977239 0.5735016622 0.752633402 12 27672427 27672483 57 + 1.425 1.436 0.040
ENSG00000110841 E037 21.6029706 0.0175474586 0.3551634321 0.591893731 12 27673767 27673827 61 + 1.330 1.317 -0.043
ENSG00000110841 E038 17.1649531 0.0067110717 0.0433029033 0.163343825 12 27674192 27674221 30 + 1.270 1.152 -0.416
ENSG00000110841 E039 36.3748870 0.0062549691 0.2820997523 0.522455057 12 27676428 27676599 172 + 1.546 1.553 0.024
ENSG00000110841 E040 4.6496442 0.0125094549 0.6458742427 0.800738080 12 27676600 27677063 464 + 0.732 0.721 -0.045
ENSG00000110841 E041 5.1432573 0.0089849665 0.3960839915 0.625220759 12 27677064 27677096 33 + 0.782 0.721 -0.247
ENSG00000110841 E042 7.3339151 0.0047128872 0.4658332834 0.677193952 12 27677097 27677992 896 + 0.906 0.882 -0.091
ENSG00000110841 E043 34.2965923 0.0010596268 0.0285572630 0.123016515 12 27679489 27679639 151 + 1.543 1.481 -0.213
ENSG00000110841 E044 0.7608862 0.2455392171 0.3023417084   12 27679800 27679932 133 + 0.157 0.382 1.702
ENSG00000110841 E045 37.9233824 0.0132271374 0.9582383056 0.981025189 12 27679933 27680061 129 + 1.537 1.617 0.271
ENSG00000110841 E046 44.0491219 0.0010206095 0.2916906059 0.532350794 12 27681546 27681696 151 + 1.582 1.716 0.454
ENSG00000110841 E047 39.3970964 0.0011187882 0.6868148311 0.827065804 12 27682387 27682498 112 + 1.562 1.614 0.179
ENSG00000110841 E048 22.3782981 0.0112393544 0.9461803857 0.975448063 12 27682615 27682623 9 + 1.315 1.383 0.238
ENSG00000110841 E049 35.4857830 0.0030693883 0.9276304434 0.965900364 12 27682624 27682703 80 + 1.509 1.578 0.237
ENSG00000110841 E050 41.9847611 0.0012822321 0.2738385147 0.513766385 12 27687385 27687507 123 + 1.602 1.615 0.044
ENSG00000110841 E051 0.1426347 0.0320499835 0.8968705056   12 27688189 27688297 109 + 0.086 0.000 -11.485
ENSG00000110841 E052 44.8807457 0.0014973298 0.9725481955 0.988245518 12 27688298 27688423 126 + 1.613 1.691 0.266
ENSG00000110841 E053 53.6501507 0.0012279319 0.8683255212 0.935043216 12 27689015 27689203 189 + 1.688 1.757 0.234
ENSG00000110841 E054 59.9321029 0.0031670601 0.5821762969 0.758486874 12 27691749 27691928 180 + 1.726 1.831 0.356
ENSG00000110841 E055 33.3520137 0.0013205864 0.0323460130 0.134223506 12 27692591 27692656 66 + 1.441 1.647 0.704
ENSG00000110841 E056 212.2852921 1.4438308042 0.2761282795 0.516140720 12 27692796 27695564 2769 + 2.096 2.552 1.520