ENSG00000110756

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000349215 ENSG00000110756 HEK293_OSMI2_6hA HEK293_TMG_6hB HPS5 protein_coding protein_coding 7.231863 2.503971 11.35467 0.2632913 0.3611642 2.176516 0.9683258 0.35122038 2.1381314 0.23922585 0.54374256 2.572131 0.14357917 0.13286667 0.18926667 0.05640000 0.81314027 0.03234178 FALSE TRUE
ENST00000396253 ENSG00000110756 HEK293_OSMI2_6hA HEK293_TMG_6hB HPS5 protein_coding protein_coding 7.231863 2.503971 11.35467 0.2632913 0.3611642 2.176516 1.4580257 0.88177221 1.5943992 0.16938412 0.32683874 0.847286 0.24338333 0.35293333 0.14250000 -0.21043333 0.11830945 0.03234178 FALSE TRUE
ENST00000438420 ENSG00000110756 HEK293_OSMI2_6hA HEK293_TMG_6hB HPS5 protein_coding protein_coding 7.231863 2.503971 11.35467 0.2632913 0.3611642 2.176516 2.0791250 0.72629994 3.0447685 0.44960021 0.61947431 2.052698 0.27072500 0.28060000 0.26553333 -0.01506667 0.97131559 0.03234178 FALSE TRUE
ENST00000537258 ENSG00000110756 HEK293_OSMI2_6hA HEK293_TMG_6hB HPS5 protein_coding protein_coding 7.231863 2.503971 11.35467 0.2632913 0.3611642 2.176516 0.5631987 0.21577383 0.5758764 0.05355131 0.18935962 1.375718 0.09664167 0.09030000 0.05006667 -0.04023333 0.68617028 0.03234178 FALSE TRUE
ENST00000544218 ENSG00000110756 HEK293_OSMI2_6hA HEK293_TMG_6hB HPS5 protein_coding protein_coding 7.231863 2.503971 11.35467 0.2632913 0.3611642 2.176516 0.5994541 0.16503981 1.2956192 0.05954484 0.23931880 2.898979 0.07486667 0.07233333 0.11306667 0.04073333 0.71843194 0.03234178 TRUE FALSE
MSTRG.5243.4 ENSG00000110756 HEK293_OSMI2_6hA HEK293_TMG_6hB HPS5 protein_coding   7.231863 2.503971 11.35467 0.2632913 0.3611642 2.176516 0.8820439 0.05485011 2.0802636 0.05485011 0.04269982 5.010432 0.08327500 0.02133333 0.18340000 0.16206667 0.03234178 0.03234178 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000110756 E001 0.9475002 0.0165325334 1.831353e-01   11 18278668 18278675 8 - 0.307 0.000 -10.440
ENSG00000110756 E002 21.9492124 0.0130365345 9.051515e-02 0.2647301090 11 18278676 18279058 383 - 1.244 1.401 0.550
ENSG00000110756 E003 38.0664086 0.0087508640 1.250623e-02 0.0684515310 11 18279059 18279333 275 - 1.468 1.654 0.635
ENSG00000110756 E004 69.4398503 0.0005908044 1.474679e-02 0.0771350535 11 18279334 18279617 284 - 1.739 1.851 0.379
ENSG00000110756 E005 35.9305059 0.0014842892 1.377261e-01 0.3440334635 11 18279618 18279667 50 - 1.464 1.560 0.330
ENSG00000110756 E006 64.0194370 0.0007383088 1.914932e-05 0.0003685815 11 18279668 18279942 275 - 1.677 1.880 0.684
ENSG00000110756 E007 1.3462616 0.0370675834 4.440148e-01   11 18280509 18280642 134 - 0.306 0.450 0.827
ENSG00000110756 E008 0.3503582 0.0448426742 3.495146e-01   11 18281914 18281949 36 - 0.069 0.206 1.828
ENSG00000110756 E009 68.8214024 0.0008899196 1.671721e-04 0.0023017402 11 18281950 18282220 271 - 1.716 1.890 0.588
ENSG00000110756 E010 0.3040503 0.0274424043 1.000000e+00   11 18283793 18283794 2 - 0.128 0.000 -10.003
ENSG00000110756 E011 44.2909170 0.0009004213 2.108426e-01 0.4427797726 11 18283795 18283901 107 - 1.562 1.633 0.243
ENSG00000110756 E012 27.5872527 0.0012648005 9.302632e-01 0.9671033512 11 18285346 18285372 27 - 1.379 1.382 0.010
ENSG00000110756 E013 42.9666974 0.0009007490 9.460985e-01 0.9753948245 11 18285373 18285459 87 - 1.568 1.559 -0.028
ENSG00000110756 E014 47.0637022 0.0034448538 7.821553e-01 0.8859534270 11 18286591 18286710 120 - 1.611 1.588 -0.079
ENSG00000110756 E015 4.6359252 0.0059025946 7.697507e-01 0.8785215330 11 18286711 18286914 204 - 0.678 0.721 0.177
ENSG00000110756 E016 56.3551619 0.0099535016 5.965882e-01 0.7680383673 11 18287535 18287690 156 - 1.692 1.646 -0.154
ENSG00000110756 E017 1.9195065 0.0343302146 7.892196e-01 0.8900227660 11 18287891 18287892 2 - 0.405 0.451 0.242
ENSG00000110756 E018 48.8089382 0.0079532017 3.246181e-01 0.5638789359 11 18287893 18288013 121 - 1.633 1.553 -0.270
ENSG00000110756 E019 98.5698618 0.0005220361 6.077867e-02 0.2045788300 11 18291442 18292019 578 - 1.938 1.854 -0.283
ENSG00000110756 E020 40.9758061 0.0204471835 1.542942e-01 0.3683932442 11 18292899 18292976 78 - 1.577 1.439 -0.473
ENSG00000110756 E021 50.0055039 0.0036831176 5.361636e-03 0.0365057664 11 18295020 18295169 150 - 1.666 1.471 -0.667
ENSG00000110756 E022 40.2391778 0.0010474829 8.895307e-01 0.9464789818 11 18295999 18296122 124 - 1.538 1.544 0.020
ENSG00000110756 E023 1.3245774 0.3622618967 1.997220e-01   11 18296162 18296797 636 - 0.230 0.536 1.803
ENSG00000110756 E024 48.4840956 0.0012519299 7.043498e-01 0.8383607468 11 18296798 18296984 187 - 1.613 1.633 0.067
ENSG00000110756 E025 36.4879864 0.0037291495 2.385531e-01 0.4749499117 11 18297559 18297717 159 - 1.481 1.559 0.269
ENSG00000110756 E026 43.5396193 0.0014750781 8.689724e-01 0.9354052351 11 18298792 18298970 179 - 1.568 1.574 0.022
ENSG00000110756 E027 29.1029020 0.0098178895 2.068034e-01 0.4379076327 11 18300828 18300916 89 - 1.420 1.299 -0.422
ENSG00000110756 E028 27.8549375 0.0030440566 1.685124e-01 0.3885895139 11 18305422 18305493 72 - 1.404 1.284 -0.418
ENSG00000110756 E029 50.8383081 0.0048650129 6.508221e-02 0.2140828604 11 18306135 18306347 213 - 1.660 1.529 -0.447
ENSG00000110756 E030 40.2738389 0.0008979916 1.638222e-01 0.3823742316 11 18308946 18309079 134 - 1.560 1.462 -0.335
ENSG00000110756 E031 42.9245100 0.0013120504 3.103579e-02 0.1304343503 11 18310741 18310933 193 - 1.595 1.443 -0.519
ENSG00000110756 E032 22.1939666 0.0336237088 3.569735e-01 0.5932548180 11 18311387 18311451 65 - 1.311 1.181 -0.459
ENSG00000110756 E033 0.1308682 0.0326491905 1.218124e-01   11 18311517 18311913 397 - 0.000 0.206 12.023
ENSG00000110756 E034 18.4546701 0.0179636686 2.893070e-01 0.5298348514 11 18311914 18311955 42 - 1.236 1.100 -0.484
ENSG00000110756 E035 24.4071847 0.0146599410 1.869755e-01 0.4130114468 11 18311956 18312024 69 - 1.354 1.209 -0.509
ENSG00000110756 E036 0.8461841 0.0172671820 9.928188e-01   11 18314404 18314519 116 - 0.227 0.206 -0.170
ENSG00000110756 E037 11.2235191 0.0131315086 1.299040e-01 0.3316799029 11 18317751 18317907 157 - 1.053 0.849 -0.766
ENSG00000110756 E038 16.4645688 0.0676494324 7.481091e-01 0.8655725258 11 18321946 18322076 131 - 1.180 1.128 -0.187
ENSG00000110756 E039 13.1031778 0.1387042930 5.421182e-01 0.7305849723 11 18322077 18322132 56 - 1.099 1.007 -0.339
ENSG00000110756 E040 14.7864405 0.0027167952 1.164211e-01 0.3098468379 11 18322133 18322254 122 - 1.157 0.978 -0.652