ENSG00000110697

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000356404 ENSG00000110697 HEK293_OSMI2_6hA HEK293_TMG_6hB PITPNM1 protein_coding protein_coding 8.966589 13.35916 3.737416 1.075054 0.0625103 -1.834941 3.0027174 5.8060742 0.00000000 1.4260214 0.00000000 -9.1839019 0.24300000 0.42413333 0.00000000 -0.42413333 1.137738e-10 1.137738e-10 FALSE TRUE
ENST00000436757 ENSG00000110697 HEK293_OSMI2_6hA HEK293_TMG_6hB PITPNM1 protein_coding protein_coding 8.966589 13.35916 3.737416 1.075054 0.0625103 -1.834941 1.6993187 2.5796701 1.00664732 0.1677236 0.33942623 -1.3489490 0.19986250 0.19580000 0.26790000 0.07210000 8.658700e-01 1.137738e-10 FALSE TRUE
ENST00000525568 ENSG00000110697 HEK293_OSMI2_6hA HEK293_TMG_6hB PITPNM1 protein_coding retained_intron 8.966589 13.35916 3.737416 1.075054 0.0625103 -1.834941 0.4786258 0.5105602 0.00000000 0.3251914 0.00000000 -5.7019931 0.05922500 0.04203333 0.00000000 -0.04203333 6.086211e-01 1.137738e-10 FALSE FALSE
ENST00000526450 ENSG00000110697 HEK293_OSMI2_6hA HEK293_TMG_6hB PITPNM1 protein_coding retained_intron 8.966589 13.35916 3.737416 1.075054 0.0625103 -1.834941 0.7689651 1.4115671 0.03741177 0.2259195 0.03741177 -4.9060930 0.07616667 0.10623333 0.01036667 -0.09586667 2.473264e-02 1.137738e-10 TRUE FALSE
ENST00000527370 ENSG00000110697 HEK293_OSMI2_6hA HEK293_TMG_6hB PITPNM1 protein_coding retained_intron 8.966589 13.35916 3.737416 1.075054 0.0625103 -1.834941 0.4726198 0.4968530 0.46042638 0.2058939 0.03673116 -0.1075985 0.06478333 0.03926667 0.12320000 0.08393333 1.572764e-01 1.137738e-10 FALSE TRUE
ENST00000529203 ENSG00000110697 HEK293_OSMI2_6hA HEK293_TMG_6hB PITPNM1 protein_coding retained_intron 8.966589 13.35916 3.737416 1.075054 0.0625103 -1.834941 0.3123903 0.4583759 0.34179293 0.2305099 0.07292836 -0.4129405 0.04280417 0.03420000 0.09203333 0.05783333 6.138308e-01 1.137738e-10 FALSE FALSE
MSTRG.5829.1 ENSG00000110697 HEK293_OSMI2_6hA HEK293_TMG_6hB PITPNM1 protein_coding   8.966589 13.35916 3.737416 1.075054 0.0625103 -1.834941 1.1516776 0.7544062 1.62222463 0.3778408 0.25528595 1.0944282 0.19237083 0.05446667 0.43393333 0.37946667 1.728026e-01 1.137738e-10 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000110697 E001 0.0000000       11 67491147 67491171 25 -      
ENSG00000110697 E002 0.5705883 0.1805360296 0.665030776   11 67491449 67491767 319 - 0.227 0.159 -0.635
ENSG00000110697 E003 0.2617363 0.0567262099 1.000000000   11 67491768 67491768 1 - 0.000 0.115 9.156
ENSG00000110697 E004 32.2680076 0.0011696715 0.004065209 0.02954069 11 67491769 67492009 241 - 1.205 1.453 0.866
ENSG00000110697 E005 93.2798664 0.0015992353 0.002881642 0.02269696 11 67492010 67492296 287 - 1.740 1.891 0.510
ENSG00000110697 E006 77.6830366 0.0028378845 0.967359886 0.98564646 11 67492934 67493062 129 - 1.796 1.788 -0.024
ENSG00000110697 E007 48.5505609 0.0010780492 0.390637008 0.62089664 11 67493410 67493443 34 - 1.637 1.581 -0.192
ENSG00000110697 E008 68.3299821 0.0006585053 0.191623555 0.41893030 11 67493444 67493552 109 - 1.791 1.720 -0.242
ENSG00000110697 E009 40.6164950 0.0027373043 0.270146894 0.51011459 11 67493553 67493593 41 - 1.579 1.502 -0.264
ENSG00000110697 E010 78.2731034 0.0009674887 0.006433408 0.04183896 11 67493688 67493837 150 - 1.664 1.810 0.496
ENSG00000110697 E011 6.9421163 0.0606368222 0.003936418 0.02879083 11 67493838 67493921 84 - 0.227 0.872 3.235
ENSG00000110697 E012 71.0675806 0.0050637574 0.079584165 0.24404077 11 67493922 67494070 149 - 1.657 1.761 0.353
ENSG00000110697 E013 43.7309716 0.0021582748 0.484386326 0.69014069 11 67494244 67494295 52 - 1.502 1.546 0.151
ENSG00000110697 E014 46.1875270 0.0036117504 0.607747251 0.77536388 11 67494296 67494360 65 - 1.537 1.566 0.098
ENSG00000110697 E015 60.5746910 0.0009319012 0.424701765 0.64706208 11 67494846 67494956 111 - 1.718 1.669 -0.166
ENSG00000110697 E016 50.1920939 0.0008845125 0.126585308 0.32638614 11 67495077 67495139 63 - 1.676 1.581 -0.324
ENSG00000110697 E017 48.1015917 0.0008630022 0.681448604 0.82357629 11 67495140 67495225 86 - 1.609 1.581 -0.095
ENSG00000110697 E018 1.7058430 0.4559648850 0.279437834 0.51952685 11 67495226 67495279 54 - 0.572 0.292 -1.514
ENSG00000110697 E019 66.2239094 0.0014128369 0.737608721 0.85901177 11 67495438 67495602 165 - 1.740 1.720 -0.067
ENSG00000110697 E020 60.7964326 0.0006331075 0.509285972 0.70738536 11 67496178 67496345 168 - 1.718 1.678 -0.134
ENSG00000110697 E021 15.0634225 0.0516704134 0.539838926 0.72887018 11 67496346 67496348 3 - 1.027 1.114 0.318
ENSG00000110697 E022 11.0008768 0.2176028470 0.031312618 0.13126123 11 67496349 67497230 882 - 1.312 0.845 -1.701
ENSG00000110697 E023 62.0212010 0.0006418694 0.995478217 0.99931488 11 67497231 67497436 206 - 1.695 1.692 -0.009
ENSG00000110697 E024 54.5281471 0.0007064482 0.239768197 0.47638055 11 67497522 67497679 158 - 1.578 1.649 0.239
ENSG00000110697 E025 58.1037339 0.0007936688 0.116248303 0.30955132 11 67497917 67498024 108 - 1.586 1.680 0.318
ENSG00000110697 E026 81.9652766 0.0005849030 0.648634261 0.80263639 11 67498133 67498322 190 - 1.796 1.816 0.068
ENSG00000110697 E027 7.9287085 0.1002743371 0.017163384 0.08604264 11 67498323 67498595 273 - 1.167 0.728 -1.657
ENSG00000110697 E028 86.5052431 0.0008241535 0.811870864 0.90337137 11 67498596 67498846 251 - 1.845 1.831 -0.048
ENSG00000110697 E029 55.1632699 0.0008169340 0.364096545 0.59910634 11 67498940 67499001 62 - 1.688 1.632 -0.192
ENSG00000110697 E030 0.3503582 0.0270051913 0.279495561   11 67499639 67499722 84 - 0.226 0.062 -2.165
ENSG00000110697 E031 49.9581417 0.0009976817 0.433765803 0.65405867 11 67499723 67499770 48 - 1.644 1.593 -0.173
ENSG00000110697 E032 50.4491539 0.0008618165 0.808318314 0.90120446 11 67499771 67499830 60 - 1.623 1.606 -0.058
ENSG00000110697 E033 0.6482515 0.0381129695 0.015203044   11 67499831 67499913 83 - 0.485 0.061 -3.758
ENSG00000110697 E034 52.7134479 0.0007071839 0.303491640 0.54404071 11 67499914 67500009 96 - 1.676 1.613 -0.215
ENSG00000110697 E035 0.3393995 0.0273333223 0.016788818   11 67500010 67500013 4 - 0.374 0.000 -13.534
ENSG00000110697 E036 83.7132556 0.0011596399 0.586608207 0.76134694 11 67500095 67500421 327 - 1.845 1.814 -0.104
ENSG00000110697 E037 53.6980472 0.0009142169 0.447825676 0.66410401 11 67501862 67501967 106 - 1.594 1.638 0.150
ENSG00000110697 E038 37.1220929 0.0011877929 0.497317979 0.69911039 11 67501968 67502012 45 - 1.520 1.469 -0.175
ENSG00000110697 E039 37.3361430 0.0011015444 0.847054150 0.92334498 11 67502013 67502038 26 - 1.473 1.484 0.040
ENSG00000110697 E040 29.3401723 0.0080128979 0.717261580 0.84643329 11 67502039 67502046 8 - 1.358 1.388 0.104
ENSG00000110697 E041 37.5468372 0.0030321103 0.928896745 0.96648673 11 67502047 67502086 40 - 1.482 1.488 0.021
ENSG00000110697 E042 4.1635186 0.2056802508 0.255186998 0.49378671 11 67502087 67502291 205 - 0.814 0.577 -0.990
ENSG00000110697 E043 28.3761151 0.0018276595 0.683032756 0.82457541 11 67502292 67502296 5 - 1.396 1.362 -0.119
ENSG00000110697 E044 55.1119023 0.0007616529 0.409923024 0.63594502 11 67502297 67502413 117 - 1.682 1.632 -0.172
ENSG00000110697 E045 33.6750263 0.0190624226 0.729427459 0.85389407 11 67502504 67502532 29 - 1.453 1.422 -0.107
ENSG00000110697 E046 49.0760473 0.0020478852 0.600962137 0.77083054 11 67502533 67502718 186 - 1.623 1.587 -0.122
ENSG00000110697 E047 1.2041043 0.6752368026 0.504260483   11 67503840 67503876 37 - 0.486 0.216 -1.683
ENSG00000110697 E048 20.5865726 0.0070533186 0.982971196 0.99327695 11 67504103 67504221 119 - 1.240 1.238 -0.006
ENSG00000110697 E049 0.5363366 0.0477724944 0.692343624   11 67504222 67504369 148 - 0.000 0.164 9.758
ENSG00000110697 E050 0.6064850 0.0223307343 0.476041789   11 67504522 67504557 36 - 0.000 0.206 10.165
ENSG00000110697 E051 3.2740295 0.0469736644 0.521266843 0.71574883 11 67504794 67505187 394 - 0.645 0.517 -0.577
ENSG00000110697 E052 12.3414539 0.0032568185 0.202097507 0.43222473 11 67505188 67505365 178 - 0.894 1.054 0.598
ENSG00000110697 E053 0.0000000       11 67506176 67506263 88 -