ENSG00000110442

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000263401 ENSG00000110442 HEK293_OSMI2_6hA HEK293_TMG_6hB COMMD9 protein_coding protein_coding 80.2126 98.04362 47.64046 15.3552 1.159586 -1.041081 7.840175 8.409847 4.022272 1.171450 0.3300477 -1.0622012 0.09630000 0.0863000 0.08433333 -0.001966667 0.98879119 0.04103545 FALSE  
ENST00000452374 ENSG00000110442 HEK293_OSMI2_6hA HEK293_TMG_6hB COMMD9 protein_coding protein_coding 80.2126 98.04362 47.64046 15.3552 1.159586 -1.041081 33.738752 41.337765 20.736350 8.155705 0.3001110 -0.9949518 0.42016667 0.4164667 0.43563333 0.019166667 0.91201972 0.04103545 FALSE  
ENST00000532705 ENSG00000110442 HEK293_OSMI2_6hA HEK293_TMG_6hB COMMD9 protein_coding protein_coding 80.2126 98.04362 47.64046 15.3552 1.159586 -1.041081 5.323983 10.583607 1.520388 1.223027 0.5937317 -2.7912244 0.06018333 0.1096667 0.03163333 -0.078033333 0.04103545 0.04103545 FALSE  
MSTRG.5388.4 ENSG00000110442 HEK293_OSMI2_6hA HEK293_TMG_6hB COMMD9 protein_coding   80.2126 98.04362 47.64046 15.3552 1.159586 -1.041081 10.077372 10.175163 5.318373 1.561878 0.2449957 -0.9347022 0.12034167 0.1061667 0.11203333 0.005866667 0.96256220 0.04103545 TRUE  
MSTRG.5388.5 ENSG00000110442 HEK293_OSMI2_6hA HEK293_TMG_6hB COMMD9 protein_coding   80.2126 98.04362 47.64046 15.3552 1.159586 -1.041081 21.732897 25.930073 14.303083 4.498038 1.1271893 -0.8578480 0.27867500 0.2629333 0.29943333 0.036500000 0.69404184 0.04103545 FALSE  
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000110442 E001 3.3338777 0.0086452510 1.082272e-05 0.0002248043 11 36269284 36271827 2544 - 0.964 0.304 -3.015
ENSG00000110442 E002 0.1426347 0.0311997537 1.908910e-01   11 36272196 36272291 96 - 0.180 0.000 -10.706
ENSG00000110442 E003 16.6868752 0.0040179600 7.425736e-02 0.2332705860 11 36272292 36272807 516 - 1.311 1.147 -0.580
ENSG00000110442 E004 16.8113851 0.0031462928 1.035772e-01 0.2881618411 11 36272808 36273165 358 - 1.300 1.153 -0.520
ENSG00000110442 E005 28.9583509 0.0060882434 1.631131e-03 0.0145394077 11 36273166 36273911 746 - 1.590 1.352 -0.821
ENSG00000110442 E006 7.1496951 0.0257172376 4.487687e-01 0.6648280195 11 36273912 36273959 48 - 0.939 0.828 -0.426
ENSG00000110442 E007 375.8752499 0.0015108153 9.960474e-01 0.9996498544 11 36273960 36274222 263 - 2.529 2.527 -0.005
ENSG00000110442 E008 154.5066121 0.0003552020 3.595763e-01 0.5954765313 11 36274223 36274224 2 - 2.163 2.132 -0.104
ENSG00000110442 E009 352.1335283 0.0001682442 1.810527e-01 0.4053326456 11 36274225 36274324 100 - 2.477 2.504 0.088
ENSG00000110442 E010 246.9232437 0.0005178045 7.152276e-01 0.8450894628 11 36274325 36274355 31 - 2.336 2.345 0.030
ENSG00000110442 E011 288.6556774 0.0002502432 8.784395e-01 0.9405117252 11 36274356 36274420 65 - 2.413 2.408 -0.017
ENSG00000110442 E012 238.8824066 0.0002578779 1.703861e-01 0.3909565437 11 36274421 36274472 52 - 2.303 2.337 0.114
ENSG00000110442 E013 495.9376649 0.0001342295 4.657079e-03 0.0327757599 11 36274473 36274639 167 - 2.610 2.658 0.161
ENSG00000110442 E014 578.5754905 0.0001334283 7.550746e-01 0.8697326795 11 36274640 36274762 123 - 2.716 2.710 -0.022
ENSG00000110442 E015 310.2337758 0.0014033540 1.204152e-02 0.0666187058 11 36274763 36274772 10 - 2.489 2.421 -0.227
ENSG00000110442 E016 446.2122885 0.0006615744 7.232177e-01 0.8500780278 11 36276137 36276240 104 - 2.605 2.598 -0.025
ENSG00000110442 E017 4.2061949 0.0308015227 5.315747e-01 0.7231317871 11 36276241 36276416 176 - 0.751 0.647 -0.432
ENSG00000110442 E018 8.9935683 0.0188225381 1.030291e-05 0.0002152912 11 36276467 36277088 622 - 1.266 0.723 -2.025
ENSG00000110442 E019 348.0996534 0.0001598215 4.039436e-02 0.1557508120 11 36277089 36277123 35 - 2.523 2.479 -0.147
ENSG00000110442 E020 2.6110291 0.0486025116 1.081346e-01 0.2959407059 11 36278201 36278476 276 - 0.708 0.420 -1.333
ENSG00000110442 E021 539.8716703 0.0001904933 2.305975e-01 0.4658329565 11 36278477 36278616 140 - 2.670 2.689 0.063
ENSG00000110442 E022 385.5475998 0.0008851299 2.425521e-01 0.4794213535 11 36280712 36280837 126 - 2.520 2.546 0.088
ENSG00000110442 E023 202.3055395 0.0003460873 1.022961e-01 0.2858967776 11 36289362 36289449 88 - 2.227 2.272 0.150