ENSG00000110427

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000265654 ENSG00000110427 HEK293_OSMI2_6hA HEK293_TMG_6hB KIAA1549L protein_coding protein_coding 1.634374 1.695382 1.361744 0.08399693 0.06987336 -0.3140836 0.04000042 0.1465864 0.0000000 0.11075189 0.00000000 -3.96888669 0.02357083 0.0854000 0.0000000 -0.08540000 0.457407076 0.002324633 FALSE TRUE
ENST00000321505 ENSG00000110427 HEK293_OSMI2_6hA HEK293_TMG_6hB KIAA1549L protein_coding protein_coding 1.634374 1.695382 1.361744 0.08399693 0.06987336 -0.3140836 0.18965394 0.2498857 0.2870491 0.13149145 0.14374656 0.19282415 0.11854167 0.1556333 0.2222000 0.06656667 0.969062940 0.002324633 FALSE TRUE
ENST00000526400 ENSG00000110427 HEK293_OSMI2_6hA HEK293_TMG_6hB KIAA1549L protein_coding protein_coding 1.634374 1.695382 1.361744 0.08399693 0.06987336 -0.3140836 0.28344449 0.1022542 0.2811263 0.10225416 0.04406044 1.37487640 0.15199167 0.0555000 0.2057000 0.15020000 0.348362002 0.002324633 FALSE TRUE
ENST00000658780 ENSG00000110427 HEK293_OSMI2_6hA HEK293_TMG_6hB KIAA1549L protein_coding protein_coding 1.634374 1.695382 1.361744 0.08399693 0.06987336 -0.3140836 0.45770416 0.4507052 0.4071217 0.06831509 0.03540918 -0.14337546 0.26953333 0.2637333 0.2982667 0.03453333 0.929222931 0.002324633 FALSE TRUE
MSTRG.5360.2 ENSG00000110427 HEK293_OSMI2_6hA HEK293_TMG_6hB KIAA1549L protein_coding   1.634374 1.695382 1.361744 0.08399693 0.06987336 -0.3140836 0.19835193 0.3764930 0.0000000 0.13443427 0.00000000 -5.27237042 0.14550833 0.2243333 0.0000000 -0.22433333 0.002324633 0.002324633 FALSE TRUE
MSTRG.5360.4 ENSG00000110427 HEK293_OSMI2_6hA HEK293_TMG_6hB KIAA1549L protein_coding   1.634374 1.695382 1.361744 0.08399693 0.06987336 -0.3140836 0.46521861 0.3694579 0.3864472 0.19647149 0.16236964 0.06318889 0.29085417 0.2154000 0.2738667 0.05846667 0.920358825 0.002324633 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000110427 E001 2.1228380 0.012989770 0.9023749238 0.953060263 11 33376108 33376465 358 + 0.477 0.489 0.055
ENSG00000110427 E002 0.9291287 0.015378759 0.2832142200   11 33376466 33376673 208 + 0.146 0.361 1.699
ENSG00000110427 E003 3.5527665 0.007192952 0.1616771491 0.379232612 11 33376674 33376889 216 + 0.477 0.734 1.144
ENSG00000110427 E004 13.8775868 0.002654178 0.2916285209 0.532271807 11 33541802 33542146 345 + 1.199 1.146 -0.187
ENSG00000110427 E005 9.1767498 0.003431881 0.2267168055 0.461419046 11 33542147 33542330 184 + 1.057 0.969 -0.322
ENSG00000110427 E006 17.2371112 0.004490138 0.4994976532 0.700435545 11 33542331 33542920 590 + 1.260 1.247 -0.047
ENSG00000110427 E007 46.0366434 0.002209492 0.0007428204 0.007802807 11 33542921 33544336 1416 + 1.737 1.603 -0.456
ENSG00000110427 E008 4.3642842 0.013568557 0.9080582174 0.956187696 11 33544337 33544354 18 + 0.699 0.753 0.223
ENSG00000110427 E009 28.3006296 0.001466372 0.4150858249 0.639857820 11 33544767 33545378 612 + 1.468 1.460 -0.030
ENSG00000110427 E010 13.3565359 0.002883165 0.0837017384 0.252189327 11 33547764 33547879 116 + 1.220 1.104 -0.413
ENSG00000110427 E011 18.9443983 0.002173936 0.0430099096 0.162587300 11 33551040 33551259 220 + 1.362 1.247 -0.402
ENSG00000110427 E012 12.5401118 0.003249322 0.0942555580 0.271655578 11 33552108 33552241 134 + 1.199 1.085 -0.406
ENSG00000110427 E013 18.0886652 0.001919733 0.5621177856 0.744755523 11 33559749 33559911 163 + 1.210 1.301 0.322
ENSG00000110427 E014 11.8967047 0.023606922 0.4732730063 0.682321036 11 33561676 33561735 60 + 1.010 1.135 0.455
ENSG00000110427 E015 11.8818906 0.002803386 0.4314790669 0.652322064 11 33568076 33568227 152 + 1.025 1.146 0.437
ENSG00000110427 E016 14.7198858 0.002965382 0.6540741616 0.806147767 11 33574702 33574873 172 + 1.188 1.192 0.015
ENSG00000110427 E017 18.4771375 0.054422524 0.3414678918 0.579353836 11 33583338 33583501 164 + 1.330 1.238 -0.321
ENSG00000110427 E018 17.6425305 0.143358800 0.7960964451 0.894067260 11 33591237 33591421 185 + 1.294 1.230 -0.225
ENSG00000110427 E019 17.7545656 0.047350668 0.3678957993 0.602343477 11 33598820 33598947 128 + 1.157 1.315 0.557
ENSG00000110427 E020 0.4341107 0.024441170 0.2060504851   11 33598948 33599494 547 + 0.000 0.250 13.737
ENSG00000110427 E021 20.7227301 0.027215175 0.6353920234 0.793822283 11 33606641 33606822 182 + 1.263 1.359 0.335
ENSG00000110427 E022 19.8313144 0.009245449 0.4941916477 0.696826677 11 33609749 33609966 218 + 1.314 1.301 -0.045
ENSG00000110427 E023 13.9458910 0.036213552 0.1944263233 0.422627533 11 33618533 33618662 130 + 1.222 1.117 -0.374
ENSG00000110427 E024 22.8580513 0.016643205 0.9037213292 0.953773876 11 33645686 33646036 351 + 1.324 1.382 0.202
ENSG00000110427 E025 10.5498120 0.005219330 0.4684396619 0.679001611 11 33656012 33656109 98 + 0.974 1.095 0.443
ENSG00000110427 E026 15.2609539 0.007729026 0.3792719652 0.611608502 11 33658750 33658898 149 + 1.127 1.257 0.462
ENSG00000110427 E027 14.9171803 0.010493726 0.4844140934 0.690162879 11 33660863 33661014 152 + 1.126 1.239 0.403
ENSG00000110427 E028 179.3432601 0.123583025 0.2029761054 0.433296182 11 33667873 33674102 6230 + 2.134 2.303 0.565