ENSG00000110395

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000264033 ENSG00000110395 HEK293_OSMI2_6hA HEK293_TMG_6hB CBL protein_coding protein_coding 6.533569 8.323141 6.641705 0.2420191 0.5106379 -0.3251361 6.1041347 8.16039214 6.0625329 0.25368065 0.4765477 -0.4281069 0.9360792 0.980333333 0.91333333 -0.0670 0.134371997 0.007078269 FALSE TRUE
ENST00000634840 ENSG00000110395 HEK293_OSMI2_6hA HEK293_TMG_6hB CBL protein_coding protein_coding 6.533569 8.323141 6.641705 0.2420191 0.5106379 -0.3251361 0.2839854 0.01164019 0.4372861 0.01164019 0.2082517 4.3694128 0.0421625 0.001366667 0.06456667 0.0632 0.007078269 0.007078269 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000110395 E001 0.3088520 0.070319042 6.531377e-01   11 119206298 119206299 2 + 0.118 0.124 0.081
ENSG00000110395 E002 0.3088520 0.070319042 6.531377e-01   11 119206300 119206311 12 + 0.118 0.124 0.081
ENSG00000110395 E003 4.0283987 0.137762934 8.098396e-01 9.020923e-01 11 119206312 119206338 27 + 0.586 0.797 0.884
ENSG00000110395 E004 8.6648981 0.150623371 4.862734e-01 6.914429e-01 11 119206339 119206400 62 + 0.902 1.059 0.583
ENSG00000110395 E005 9.3165302 0.081438935 3.514567e-01 5.885920e-01 11 119206401 119206423 23 + 0.948 1.075 0.466
ENSG00000110395 E006 30.0564063 0.112062755 2.176794e-02 1.018234e-01 11 119206424 119206612 189 + 1.524 1.458 -0.227
ENSG00000110395 E007 51.1184327 0.112085732 7.115302e-03 4.516153e-02 11 119232448 119232695 248 + 1.776 1.646 -0.441
ENSG00000110395 E008 37.4122258 0.091574340 1.003164e-02 5.829268e-02 11 119271735 119271881 147 + 1.622 1.543 -0.271
ENSG00000110395 E009 42.4869393 0.092878411 3.270936e-02 1.352497e-01 11 119273868 119274024 157 + 1.644 1.633 -0.040
ENSG00000110395 E010 20.8746346 0.065468659 4.269907e-02 1.617688e-01 11 119274832 119274851 20 + 1.328 1.356 0.098
ENSG00000110395 E011 38.9337429 0.048845429 2.934789e-03 2.300778e-02 11 119274852 119274953 102 + 1.620 1.584 -0.123
ENSG00000110395 E012 48.1334579 0.068102367 8.548615e-03 5.183034e-02 11 119275997 119276134 138 + 1.706 1.675 -0.105
ENSG00000110395 E013 37.2914664 0.068399194 3.440455e-03 2.598739e-02 11 119277757 119277844 88 + 1.622 1.539 -0.285
ENSG00000110395 E014 46.1642378 0.117638015 2.878264e-02 1.237237e-01 11 119278166 119278297 132 + 1.698 1.646 -0.177
ENSG00000110395 E015 48.3579990 0.094974925 1.162664e-02 6.491767e-02 11 119278510 119278713 204 + 1.728 1.655 -0.248
ENSG00000110395 E016 31.5756888 0.068386940 2.338611e-03 1.930348e-02 11 119284969 119285100 132 + 1.563 1.456 -0.367
ENSG00000110395 E017 71.3736507 0.082548271 3.387440e-03 2.568607e-02 11 119285189 119285566 378 + 1.904 1.810 -0.314
ENSG00000110395 E018 41.4146721 0.122088076 1.139883e-02 6.398647e-02 11 119287852 119287946 95 + 1.687 1.558 -0.438
ENSG00000110395 E019 48.4338180 0.068344794 1.265545e-03 1.189762e-02 11 119296918 119297034 117 + 1.747 1.631 -0.395
ENSG00000110395 E020 36.2049251 0.040205946 4.515311e-04 5.235236e-03 11 119297384 119297481 98 + 1.610 1.529 -0.278
ENSG00000110395 E021 22.4708623 0.037918729 4.214620e-04 4.939364e-03 11 119298358 119298371 14 + 1.427 1.312 -0.398
ENSG00000110395 E022 38.8063168 0.001898607 1.934789e-06 5.069767e-05 11 119298372 119298540 169 + 1.612 1.608 -0.014
ENSG00000110395 E023 28.5892242 0.123263260 8.917030e-01 9.474677e-01 11 119299495 119299587 93 + 1.384 1.552 0.578
ENSG00000110395 E024 21.9120143 0.160442966 7.645863e-01 8.753688e-01 11 119299588 119299635 48 + 1.221 1.474 0.880
ENSG00000110395 E025 1165.4733074 1.800788597 5.403792e-01 7.292673e-01 11 119299636 119306287 6652 + 2.853 3.214 1.202
ENSG00000110395 E026 73.3877103 0.288773274 9.862720e-02 2.793949e-01 11 119306288 119306380 93 + 1.527 2.068 1.827
ENSG00000110395 E027 372.4244669 1.079070768 1.954655e-01 4.239513e-01 11 119306381 119307478 1098 + 2.150 2.789 2.131
ENSG00000110395 E028 146.1903481 0.384439053 2.327875e-02 1.068258e-01 11 119307479 119308069 591 + 1.627 2.409 2.624
ENSG00000110395 E029 5.9805203 0.355672148 2.904505e-02 1.244905e-01 11 119308070 119308149 80 + 0.207 1.096 4.228
ENSG00000110395 E030 0.6486114 0.018976897 6.695516e-01   11 119313418 119313421 4 + 0.118 0.301 1.679
ENSG00000110395 E031 2.3702713 0.010834521 5.494134e-01 7.359153e-01 11 119313422 119313926 505 + 0.352 0.637 1.419