ENSG00000110367

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000534980 ENSG00000110367 HEK293_OSMI2_6hA HEK293_TMG_6hB DDX6 protein_coding protein_coding 24.58788 12.33838 38.02071 3.743302 1.555032 1.622843 4.077773 1.48548011 7.499808 0.42072460 0.3269703 2.328167 0.15580000 0.123266667 0.1985667 0.0753000 2.279724e-01 2.76507e-10 FALSE TRUE
ENST00000620157 ENSG00000110367 HEK293_OSMI2_6hA HEK293_TMG_6hB DDX6 protein_coding protein_coding 24.58788 12.33838 38.02071 3.743302 1.555032 1.622843 16.837763 10.65190822 23.229652 3.38287874 1.8557800 1.124123 0.73235000 0.853300000 0.6094000 -0.2439000 1.247609e-04 2.76507e-10 FALSE TRUE
MSTRG.6390.3 ENSG00000110367 HEK293_OSMI2_6hA HEK293_TMG_6hB DDX6 protein_coding   24.58788 12.33838 38.02071 3.743302 1.555032 1.622843 2.856809 0.07186956 5.648394 0.03035054 0.6095102 6.110922 0.08409167 0.006666667 0.1492333 0.1425667 2.765070e-10 2.76507e-10 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000110367 E001 0.9524741 0.018491747 5.646714e-02   11 118747763 118747765 3 - 0.135 0.516 2.645
ENSG00000110367 E002 474.7901256 0.010276930 3.750808e-07 1.200478e-05 11 118747766 118748358 593 - 2.492 2.853 1.203
ENSG00000110367 E003 541.6996766 0.008580763 3.341048e-06 8.143919e-05 11 118748359 118748780 422 - 2.567 2.885 1.057
ENSG00000110367 E004 1446.5449596 0.004718741 1.580382e-04 2.195560e-03 11 118748781 118751364 2584 - 3.041 3.231 0.631
ENSG00000110367 E005 428.1713133 1.814823979 6.469925e-01 8.014633e-01 11 118751365 118752097 733 - 2.533 2.662 0.430
ENSG00000110367 E006 1.3854848 0.231366266 5.946484e-01   11 118754589 118754704 116 - 0.285 0.440 0.921
ENSG00000110367 E007 212.3827982 0.016422813 3.048839e-01 5.454634e-01 11 118754705 118754887 183 - 2.266 2.264 -0.009
ENSG00000110367 E008 176.4096141 0.003974040 6.007819e-04 6.584452e-03 11 118755402 118755503 102 - 2.198 2.140 -0.193
ENSG00000110367 E009 129.6330852 0.007362655 1.499441e-03 1.361563e-02 11 118756260 118756323 64 - 2.071 1.992 -0.266
ENSG00000110367 E010 200.1203102 0.004550654 2.188636e-04 2.880799e-03 11 118757171 118757287 117 - 2.254 2.193 -0.204
ENSG00000110367 E011 198.5349779 0.008753662 2.350952e-03 1.938180e-02 11 118758774 118758902 129 - 2.250 2.191 -0.198
ENSG00000110367 E012 2.1192921 0.010644106 6.818278e-02 2.210029e-01 11 118758903 118759369 467 - 0.504 0.196 -1.943
ENSG00000110367 E013 183.6170150 0.006269541 5.205829e-04 5.860586e-03 11 118759922 118760044 123 - 2.220 2.149 -0.237
ENSG00000110367 E014 168.6626095 0.003015298 1.375756e-07 4.955145e-06 11 118763212 118763306 95 - 2.194 2.067 -0.426
ENSG00000110367 E015 188.7728761 0.007242471 3.646355e-05 6.372697e-04 11 118765209 118765355 147 - 2.240 2.124 -0.391
ENSG00000110367 E016 0.4702677 0.021771034 8.641595e-01   11 118767627 118768222 596 - 0.135 0.196 0.639
ENSG00000110367 E017 180.0467856 0.011997769 1.167186e-04 1.699812e-03 11 118768223 118768352 130 - 2.226 2.074 -0.508
ENSG00000110367 E018 171.4453101 0.007393742 2.589458e-07 8.666723e-06 11 118779632 118779736 105 - 2.212 2.026 -0.619
ENSG00000110367 E019 0.0000000       11 118781120 118781120 1 -      
ENSG00000110367 E020 135.7399441 0.010309777 7.607784e-07 2.240125e-05 11 118781121 118781184 64 - 2.120 1.896 -0.750
ENSG00000110367 E021 0.8214337 0.017267182 1.494503e-01   11 118785833 118786051 219 - 0.282 0.000 -10.129
ENSG00000110367 E022 250.1460426 0.016427154 7.259061e-07 2.151030e-05 11 118786052 118786518 467 - 2.386 2.137 -0.834
ENSG00000110367 E023 3.4671268 0.339949525 2.509611e-01 4.890269e-01 11 118786519 118790359 3841 - 0.473 0.844 1.604
ENSG00000110367 E024 1.6288880 0.107279764 1.929334e-01 4.207108e-01 11 118790855 118790886 32 - 0.425 0.195 -1.553
ENSG00000110367 E025 12.3647771 0.085534339 7.217848e-03 4.566151e-02 11 118790887 118791097 211 - 1.136 0.699 -1.664
ENSG00000110367 E026 32.7717485 0.001611895 1.691750e-03 1.496733e-02 11 118791098 118791630 533 - 1.498 1.355 -0.494