ENSG00000110080

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000227495 ENSG00000110080 HEK293_OSMI2_6hA HEK293_TMG_6hB ST3GAL4 protein_coding protein_coding 21.74476 32.65794 10.99768 5.026155 0.5723551 -1.569365 2.300995 5.210797 0.1566765 1.1937327 0.0865901 -4.96914751 0.09761667 0.1556333 0.0136000 -0.14203333 0.0003133608 0.0003133608 FALSE TRUE
ENST00000444328 ENSG00000110080 HEK293_OSMI2_6hA HEK293_TMG_6hB ST3GAL4 protein_coding protein_coding 21.74476 32.65794 10.99768 5.026155 0.5723551 -1.569365 11.838291 17.308870 5.2551883 3.5462227 0.5305963 -1.71778775 0.53550000 0.5199667 0.4801000 -0.03986667 0.9154970128 0.0003133608 FALSE TRUE
ENST00000534457 ENSG00000110080 HEK293_OSMI2_6hA HEK293_TMG_6hB ST3GAL4 protein_coding protein_coding 21.74476 32.65794 10.99768 5.026155 0.5723551 -1.569365 3.843582 4.251557 4.2004847 0.3154283 0.6454761 -0.01739429 0.19298750 0.1412667 0.3806333 0.23936667 0.0352911476 0.0003133608 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000110080 E001 1.0709555 0.0152530965 1.549335e-01   11 126355640 126355659 20 + 0.000 0.331 11.323
ENSG00000110080 E002 3.2910823 0.0582834496 7.956884e-03 0.049124291 11 126355660 126355668 9 + 0.000 0.653 14.329
ENSG00000110080 E003 5.7497201 0.0079533223 1.761416e-03 0.015440973 11 126355669 126355685 17 + 0.214 0.836 3.203
ENSG00000110080 E004 5.7497201 0.0079533223 1.761416e-03 0.015440973 11 126355686 126355687 2 + 0.214 0.836 3.203
ENSG00000110080 E005 15.0718975 0.0083663013 9.348152e-05 0.001413400 11 126355688 126355720 33 + 0.622 1.193 2.199
ENSG00000110080 E006 51.2548445 0.0009027175 1.052869e-04 0.001562130 11 126355721 126355842 122 + 1.401 1.670 0.919
ENSG00000110080 E007 0.6368449 0.0189346563 4.014183e-01   11 126355894 126355973 80 + 0.000 0.218 12.311
ENSG00000110080 E008 7.0948434 0.0044106632 2.834581e-04 0.003562326 11 126355974 126356273 300 + 0.214 0.913 3.495
ENSG00000110080 E009 3.7013475 0.0077576320 2.472036e-03 0.020141462 11 126356274 126356302 29 + 0.000 0.677 14.774
ENSG00000110080 E010 1.5881513 0.0172252327 9.904281e-01 0.996938431 11 126358198 126358348 151 + 0.357 0.363 0.033
ENSG00000110080 E011 0.1723744 0.0429667524 1.000000e+00   11 126358415 126358511 97 + 0.000 0.066 10.152
ENSG00000110080 E012 0.0000000       11 126375020 126375124 105 +      
ENSG00000110080 E013 0.0000000       11 126392175 126392354 180 +      
ENSG00000110080 E014 0.1308682 0.0326491905 1.000000e+00   11 126393228 126393303 76 + 0.000 0.066 10.222
ENSG00000110080 E015 0.1308682 0.0326491905 1.000000e+00   11 126403218 126403415 198 + 0.000 0.066 10.222
ENSG00000110080 E016 0.1308682 0.0326491905 1.000000e+00   11 126403416 126403427 12 + 0.000 0.066 10.222
ENSG00000110080 E017 0.1308682 0.0326491905 1.000000e+00   11 126403428 126403486 59 + 0.000 0.066 10.222
ENSG00000110080 E018 0.1426347 0.0319610563 1.117798e-01   11 126405587 126405699 113 + 0.214 0.000 -13.307
ENSG00000110080 E019 0.8209858 0.0180781229 1.000000e+00   11 126405782 126406095 314 + 0.214 0.219 0.041
ENSG00000110080 E020 36.1262389 0.0009872451 1.919955e-02 0.093144568 11 126406096 126406096 1 + 1.330 1.512 0.630
ENSG00000110080 E021 83.6005634 0.0006739981 5.444971e-03 0.036944397 11 126406097 126406171 75 + 1.715 1.859 0.485
ENSG00000110080 E022 0.1779838 0.0350222413 1.115649e-01   11 126406187 126406194 8 + 0.214 0.000 -13.273
ENSG00000110080 E023 0.6120945 0.0194610699 8.120592e-01   11 126406195 126406310 116 + 0.214 0.173 -0.380
ENSG00000110080 E024 0.1723744 0.0429667524 1.000000e+00   11 126406311 126406459 149 + 0.000 0.066 10.152
ENSG00000110080 E025 0.0000000       11 126406460 126406472 13 +      
ENSG00000110080 E026 74.9897287 0.0039477788 6.195642e-02 0.207182407 11 126406473 126406502 30 + 1.693 1.806 0.381
ENSG00000110080 E027 94.8476681 0.0004527547 1.615039e-01 0.378990966 11 126406503 126406545 43 + 1.836 1.902 0.223
ENSG00000110080 E028 58.5576621 0.0007150488 8.375399e-01 0.918062388 11 126406546 126406557 12 + 1.671 1.685 0.048
ENSG00000110080 E029 0.0000000       11 126406558 126406693 136 +      
ENSG00000110080 E030 0.0000000       11 126406782 126406942 161 +      
ENSG00000110080 E031 131.8570578 0.0003257687 6.848459e-01 0.825856491 11 126406943 126407023 81 + 2.041 2.028 -0.043
ENSG00000110080 E032 0.5823548 0.0229496481 1.891395e-01   11 126407024 126407026 3 + 0.357 0.123 -1.966
ENSG00000110080 E033 160.0389292 0.0003525554 2.603872e-01 0.499347641 11 126407252 126407349 98 + 2.144 2.108 -0.118
ENSG00000110080 E034 132.1433807 0.0003233607 8.139705e-01 0.904639667 11 126407574 126407634 61 + 2.038 2.032 -0.021
ENSG00000110080 E035 157.5267092 0.0004416949 2.716382e-01 0.511483530 11 126408099 126408194 96 + 2.135 2.100 -0.117
ENSG00000110080 E036 211.8315923 0.0005755028 2.081981e-02 0.098731726 11 126408307 126408449 143 + 2.289 2.222 -0.222
ENSG00000110080 E037 148.3293209 0.0003205434 6.012550e-02 0.203100859 11 126408450 126408496 47 + 2.129 2.067 -0.209
ENSG00000110080 E038 3.3794096 0.1638998878 8.315861e-01 0.914718316 11 126408497 126408804 308 + 0.617 0.570 -0.212
ENSG00000110080 E039 235.0573874 0.0002654168 4.245561e-01 0.646960246 11 126409268 126409411 144 + 2.296 2.276 -0.067
ENSG00000110080 E040 19.6360994 0.0935990599 6.132663e-01 0.779144556 11 126409412 126410575 1164 + 1.288 1.203 -0.301
ENSG00000110080 E041 1.4330802 0.0125403564 8.931678e-01 0.948257574 11 126413330 126413396 67 + 0.357 0.331 -0.155
ENSG00000110080 E042 3.3549017 0.0162748993 1.493045e-01 0.361233468 11 126413397 126413504 108 + 0.737 0.496 -1.066
ENSG00000110080 E043 169.0792788 0.0003116568 9.021393e-01 0.952953133 11 126413505 126413586 82 + 2.133 2.139 0.020
ENSG00000110080 E044 172.6886877 0.0003572106 3.762789e-01 0.609228958 11 126413587 126413648 62 + 2.169 2.142 -0.088
ENSG00000110080 E045 326.1825734 0.0003373935 5.451570e-01 0.732788865 11 126413961 126414638 678 + 2.432 2.420 -0.039
ENSG00000110080 E046 5.0785191 0.0053376893 8.925340e-01 0.947863188 11 126440186 126440319 134 + 0.683 0.706 0.097
ENSG00000110080 E047 1.8536256 0.5992655357 9.207168e-01 0.962585461 11 126440320 126440344 25 + 0.358 0.390 0.182
ENSG00000110080 E048 5.5321689 0.0053515418 1.105764e-01 0.299936435 11 126458946 126459128 183 + 0.903 0.678 -0.895
ENSG00000110080 E049 3.1258083 0.0094103328 3.721045e-02 0.147492613 11 126459390 126459551 162 + 0.785 0.447 -1.498
ENSG00000110080 E050 0.0000000       11 126466622 126466814 193 +