ENSG00000110075

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000265636 ENSG00000110075 HEK293_OSMI2_6hA HEK293_TMG_6hB PPP6R3 protein_coding protein_coding 29.88731 11.85862 52.40487 1.622003 1.490688 2.142824 0.4782698 0.9000383 0.000000 0.1952789 0.0000000 -6.507855 0.04258750 0.07506667 0.00000000 -0.075066667 6.551960e-20 6.55196e-20 FALSE TRUE
ENST00000265637 ENSG00000110075 HEK293_OSMI2_6hA HEK293_TMG_6hB PPP6R3 protein_coding protein_coding 29.88731 11.85862 52.40487 1.622003 1.490688 2.142824 1.1212975 0.3243540 1.179264 0.1681830 0.1457783 1.830621 0.06571667 0.02890000 0.02243333 -0.006466667 9.813906e-01 6.55196e-20 FALSE TRUE
ENST00000393800 ENSG00000110075 HEK293_OSMI2_6hA HEK293_TMG_6hB PPP6R3 protein_coding protein_coding 29.88731 11.85862 52.40487 1.622003 1.490688 2.142824 14.2579277 7.0818518 24.926217 1.2936086 0.3297699 1.814008 0.47121667 0.59130000 0.47610000 -0.115200000 5.213577e-01 6.55196e-20 FALSE TRUE
ENST00000524845 ENSG00000110075 HEK293_OSMI2_6hA HEK293_TMG_6hB PPP6R3 protein_coding protein_coding 29.88731 11.85862 52.40487 1.622003 1.490688 2.142824 0.8107573 0.0000000 3.761313 0.0000000 0.7711079 8.558923 0.01597500 0.00000000 0.07186667 0.071866667 2.115115e-08 6.55196e-20 FALSE TRUE
ENST00000529907 ENSG00000110075 HEK293_OSMI2_6hA HEK293_TMG_6hB PPP6R3 protein_coding protein_coding 29.88731 11.85862 52.40487 1.622003 1.490688 2.142824 3.1539187 0.5687281 6.722489 0.2938782 0.2439675 3.540182 0.08412917 0.05083333 0.12830000 0.077466667 6.514851e-01 6.55196e-20 FALSE FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000110075 E001 0.3393995 0.0246637284 1.000000e+00   11 68460533 68460730 198 + 0.125 0.000 -9.808
ENSG00000110075 E002 0.9994175 0.0167281496 1.776741e-01   11 68460731 68460737 7 + 0.301 0.000 -12.631
ENSG00000110075 E003 3.7489879 0.0075662508 1.472099e-03 1.341901e-02 11 68460738 68460746 9 + 0.684 0.000 -14.493
ENSG00000110075 E004 4.2829394 0.0381460021 1.227876e-03 1.163749e-02 11 68460747 68460747 1 + 0.729 0.000 -14.756
ENSG00000110075 E005 4.4443551 0.0355904768 9.400365e-04 9.422726e-03 11 68460748 68460748 1 + 0.742 0.000 -14.803
ENSG00000110075 E006 4.6223389 0.0502079901 1.008966e-03 9.981103e-03 11 68460749 68460751 3 + 0.756 0.000 -14.879
ENSG00000110075 E007 4.7649736 0.0315729455 5.612658e-04 6.233052e-03 11 68460752 68460752 1 + 0.767 0.000 -14.893
ENSG00000110075 E008 4.7649736 0.0315729455 5.612658e-04 6.233052e-03 11 68460753 68460754 2 + 0.767 0.000 -14.893
ENSG00000110075 E009 21.5562076 0.0018131144 6.259113e-03 4.099431e-02 11 68460755 68460769 15 + 1.310 1.067 -0.867
ENSG00000110075 E010 59.5322956 0.0006158038 2.290622e-05 4.290760e-04 11 68460770 68460812 43 + 1.739 1.509 -0.781
ENSG00000110075 E011 63.3983284 0.0006045729 6.599952e-05 1.055887e-03 11 68460813 68460827 15 + 1.762 1.557 -0.695
ENSG00000110075 E012 40.9131699 0.0009002489 7.325738e-02 2.313274e-01 11 68505145 68505249 105 + 1.559 1.465 -0.321
ENSG00000110075 E013 20.5373665 0.0016181041 6.281446e-01 7.893198e-01 11 68505250 68505271 22 + 1.254 1.238 -0.057
ENSG00000110075 E014 2.6592831 0.0084270042 2.774381e-01 5.174896e-01 11 68515028 68515166 139 + 0.543 0.353 -0.991
ENSG00000110075 E015 55.0743676 0.0007597603 2.835923e-04 3.563485e-03 11 68519501 68519505 5 + 1.700 1.501 -0.679
ENSG00000110075 E016 78.7196591 0.0007423648 1.022967e-03 1.009022e-02 11 68519506 68519562 57 + 1.845 1.703 -0.478
ENSG00000110075 E017 95.0021158 0.0004865854 1.835680e-03 1.595234e-02 11 68519563 68519634 72 + 1.919 1.804 -0.389
ENSG00000110075 E018 53.6980047 0.0006895633 2.290914e-02 1.056368e-01 11 68519635 68519651 17 + 1.674 1.565 -0.371
ENSG00000110075 E019 1.4332909 0.0325291118 4.170709e-01 6.414612e-01 11 68522494 68522689 196 + 0.366 0.212 -1.077
ENSG00000110075 E020 0.0000000       11 68535411 68535532 122 +      
ENSG00000110075 E021 135.3941025 0.0003390329 4.158482e-08 1.689488e-06 11 68537659 68537815 157 + 2.084 1.892 -0.642
ENSG00000110075 E022 116.0141324 0.0008051490 2.041103e-07 7.018146e-06 11 68537816 68537891 76 + 2.019 1.816 -0.684
ENSG00000110075 E023 193.7273826 0.0002732250 1.091318e-13 1.348842e-11 11 68544838 68545024 187 + 2.243 2.018 -0.753
ENSG00000110075 E024 177.3475151 0.0004129432 1.630651e-10 1.107688e-08 11 68548067 68548204 138 + 2.201 2.002 -0.667
ENSG00000110075 E025 0.3150090 0.0338522808 3.534569e-01   11 68550990 68551120 131 + 0.067 0.211 1.918
ENSG00000110075 E026 128.4655110 0.0006698724 5.480034e-07 1.679242e-05 11 68551121 68551186 66 + 2.059 1.878 -0.609
ENSG00000110075 E027 0.6378404 0.0317654681 8.910182e-01   11 68551187 68551220 34 + 0.176 0.211 0.332
ENSG00000110075 E028 154.3174831 0.0003507608 6.943120e-06 1.528125e-04 11 68554145 68554257 113 + 2.131 1.994 -0.457
ENSG00000110075 E029 15.1974051 0.0878930097 7.369411e-01 8.585532e-01 11 68558196 68558565 370 + 1.106 1.182 0.269
ENSG00000110075 E030 141.5118162 0.0016118612 8.495975e-04 8.685621e-03 11 68558566 68558641 76 + 2.089 1.977 -0.373
ENSG00000110075 E031 110.8388789 0.0071053832 6.632748e-04 7.125201e-03 11 68558642 68558679 38 + 1.994 1.812 -0.612
ENSG00000110075 E032 177.9622445 0.0019553749 2.539275e-04 3.262424e-03 11 68564303 68564423 121 + 2.188 2.072 -0.389
ENSG00000110075 E033 89.5272353 0.0023611613 8.241548e-03 5.043619e-02 11 68564424 68564432 9 + 1.891 1.782 -0.370
ENSG00000110075 E034 0.0000000       11 68566999 68567013 15 +      
ENSG00000110075 E035 185.1880408 0.0014766510 2.468412e-03 2.012739e-02 11 68567014 68567166 153 + 2.200 2.118 -0.276
ENSG00000110075 E036 166.9890355 0.0003774997 9.595942e-02 2.746737e-01 11 68569748 68569897 150 + 2.145 2.118 -0.090
ENSG00000110075 E037 121.4156125 0.0017620890 5.625417e-02 1.942113e-01 11 68571040 68571098 59 + 2.013 1.957 -0.188
ENSG00000110075 E038 82.1295471 0.0028798121 3.861777e-01 6.174502e-01 11 68571099 68571104 6 + 1.839 1.820 -0.064
ENSG00000110075 E039 0.0000000       11 68571105 68571216 112 +      
ENSG00000110075 E040 178.0190847 0.0042654143 7.416295e-01 8.614561e-01 11 68574109 68574224 116 + 2.166 2.179 0.043
ENSG00000110075 E041 159.9053745 0.0008810910 8.717333e-01 9.368932e-01 11 68575958 68576043 86 + 2.118 2.142 0.081
ENSG00000110075 E042 127.8121765 0.0031404284 7.683353e-01 8.776213e-01 11 68583043 68583129 87 + 2.017 2.061 0.147
ENSG00000110075 E043 17.9523863 0.0564068553 1.478236e-02 7.725448e-02 11 68586276 68587797 1522 + 1.092 1.437 1.212
ENSG00000110075 E044 8.3648078 0.0041983243 4.720551e-01 6.815928e-01 11 68587798 68587926 129 + 0.874 0.990 0.436
ENSG00000110075 E045 92.2470006 0.0005317230 7.576848e-01 8.712146e-01 11 68587927 68587944 18 + 1.879 1.922 0.145
ENSG00000110075 E046 121.6426314 0.0007457914 2.690831e-01 5.088583e-01 11 68587945 68587977 33 + 2.009 1.994 -0.050
ENSG00000110075 E047 127.4506155 0.0003140947 1.548356e-01 3.691460e-01 11 68587978 68588024 47 + 2.030 2.005 -0.083
ENSG00000110075 E048 152.2666308 0.0002936298 6.513749e-04 7.020273e-03 11 68590660 68590714 55 + 2.120 2.026 -0.313
ENSG00000110075 E049 253.0708484 0.0002319768 2.181402e-02 1.019630e-01 11 68591576 68591706 131 + 2.328 2.295 -0.110
ENSG00000110075 E050 247.1239950 0.0002360418 8.810366e-01 9.418314e-01 11 68596097 68596218 122 + 2.306 2.331 0.086
ENSG00000110075 E051 233.2833387 0.0002618986 3.842705e-02 1.506869e-01 11 68600341 68600494 154 + 2.265 2.351 0.288
ENSG00000110075 E052 112.3373253 0.0003628680 4.039526e-02 1.557508e-01 11 68601863 68601885 23 + 1.945 2.053 0.365
ENSG00000110075 E053 180.4126244 0.0018442686 1.571351e-01 3.724323e-01 11 68601886 68601969 84 + 2.156 2.235 0.264
ENSG00000110075 E054 213.0748131 0.0031012528 5.655577e-01 7.470750e-01 11 68603342 68603492 151 + 2.237 2.285 0.163
ENSG00000110075 E055 4.8046745 0.0781326935 4.021353e-03 2.928687e-02 11 68609473 68609610 138 + 0.500 1.029 2.164
ENSG00000110075 E056 2.3924490 0.0121525625 9.335788e-04 9.367395e-03 11 68609611 68609628 18 + 0.263 0.823 2.767
ENSG00000110075 E057 5.6236350 0.1305051710 7.591355e-03 4.744546e-02 11 68609775 68609903 129 + 0.543 1.107 2.245
ENSG00000110075 E058 110.8931696 0.0204038716 2.147428e-01 4.472074e-01 11 68609904 68609950 47 + 1.938 2.052 0.383
ENSG00000110075 E059 106.0278378 0.0593744346 1.474612e-01 3.587048e-01 11 68609951 68610023 73 + 1.900 2.080 0.601
ENSG00000110075 E060 7.1664756 0.2822751633 2.929710e-02 1.252756e-01 11 68613036 68613065 30 + 0.660 1.190 2.022
ENSG00000110075 E061 816.6571796 0.0037326914 1.355559e-10 9.361735e-09 11 68613066 68614631 1566 + 2.772 2.984 0.705
ENSG00000110075 E062 434.3322040 0.0004254344 3.089721e-67 3.086504e-63 11 68614632 68615334 703 + 2.446 2.813 1.224