ENSG00000110048

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000263847 ENSG00000110048 HEK293_OSMI2_6hA HEK293_TMG_6hB OSBP protein_coding protein_coding 24.54066 21.30337 30.35494 2.792696 1.519431 0.5106482 23.5719996 21.0280073 26.724090 2.7960773 1.2703891 0.3456825 0.9652958 0.986900000 0.88080000 -0.1061 0.0007203959 0.0007203959 FALSE TRUE
ENST00000525357 ENSG00000110048 HEK293_OSMI2_6hA HEK293_TMG_6hB OSBP protein_coding nonsense_mediated_decay 24.54066 21.30337 30.35494 2.792696 1.519431 0.5106482 0.6196095 0.1369878 2.754739 0.1369878 0.7609217 4.2333755 0.0210250 0.006566667 0.08886667 0.0823 0.0751873324 0.0007203959 TRUE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000110048 E001 1278.190902 0.0058012307 2.736150e-06 6.859481e-05 11 59574398 59576248 1851 - 3.012 3.195 0.609
ENSG00000110048 E002 518.362243 0.0006527415 2.521003e-01 4.901470e-01 11 59576249 59576719 471 - 2.684 2.745 0.202
ENSG00000110048 E003 142.994431 0.0019319264 9.733463e-01 9.885983e-01 11 59576805 59576832 28 - 2.137 2.176 0.130
ENSG00000110048 E004 287.893480 0.0002191836 9.003244e-01 9.520286e-01 11 59576833 59577025 193 - 2.438 2.479 0.138
ENSG00000110048 E005 321.641410 0.0002056349 1.262678e-02 6.895132e-02 11 59578149 59578330 182 - 2.509 2.498 -0.038
ENSG00000110048 E006 242.178498 0.0014818823 3.656241e-04 4.393672e-03 11 59580174 59580269 96 - 2.407 2.345 -0.206
ENSG00000110048 E007 211.029681 0.0003577253 6.703251e-06 1.484180e-04 11 59581451 59581554 104 - 2.353 2.278 -0.252
ENSG00000110048 E008 1.141604 0.0153787590 5.876583e-01   11 59593480 59593603 124 - 0.271 0.387 0.730
ENSG00000110048 E009 190.074517 0.0003706145 2.842694e-04 3.569088e-03 11 59593604 59593724 121 - 2.303 2.246 -0.192
ENSG00000110048 E010 6.459035 0.0290606104 4.144659e-02 1.584946e-01 11 59593725 59594009 285 - 0.961 0.697 -1.035
ENSG00000110048 E011 252.819285 0.0008037269 6.680404e-03 4.310522e-02 11 59594010 59594255 246 - 2.414 2.386 -0.095
ENSG00000110048 E012 184.510068 0.0004060486 2.889463e-03 2.274256e-02 11 59600496 59600627 132 - 2.285 2.243 -0.139
ENSG00000110048 E013 130.852000 0.0049267080 2.766801e-02 1.202966e-01 11 59600819 59600873 55 - 2.145 2.087 -0.194
ENSG00000110048 E014 173.550613 0.0035107995 2.380316e-03 1.956689e-02 11 59601283 59601385 103 - 2.274 2.197 -0.255
ENSG00000110048 E015 232.181864 0.0006286636 6.589922e-03 4.265243e-02 11 59601640 59601838 199 - 2.380 2.350 -0.100
ENSG00000110048 E016 236.628598 0.0007787331 2.332280e-03 1.926527e-02 11 59608484 59608734 251 - 2.390 2.350 -0.132
ENSG00000110048 E017 159.286824 0.0015976132 6.857308e-01 8.263346e-01 11 59610381 59610589 209 - 2.190 2.216 0.086
ENSG00000110048 E018 100.309122 0.0004230937 6.338702e-02 2.103208e-01 11 59615303 59615947 645 - 1.952 2.057 0.350
ENSG00000110048 E019 1.957822 1.8412262397 5.023553e-01 7.024150e-01 11 59615948 59617025 1078 - 0.654 0.000 -12.420