ENSG00000110046

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000377264 ENSG00000110046 HEK293_OSMI2_6hA HEK293_TMG_6hB ATG2A protein_coding protein_coding 16.35507 27.84931 8.832644 3.491925 0.6284743 -1.65561 0.8646937 0.0000000 2.3791215 0.0000000 0.52639272 7.9003364 0.09066667 0.00000000 0.26526667 0.26526667 4.869594e-18 4.519898e-40 FALSE TRUE
ENST00000418259 ENSG00000110046 HEK293_OSMI2_6hA HEK293_TMG_6hB ATG2A protein_coding protein_coding 16.35507 27.84931 8.832644 3.491925 0.6284743 -1.65561 3.8870743 7.1889436 0.2687732 0.6618807 0.26877320 -4.6906214 0.19807083 0.26040000 0.03390000 -0.22650000 1.152996e-01 4.519898e-40 FALSE TRUE
ENST00000421419 ENSG00000110046 HEK293_OSMI2_6hA HEK293_TMG_6hB ATG2A protein_coding protein_coding 16.35507 27.84931 8.832644 3.491925 0.6284743 -1.65561 3.9076248 6.7905216 0.3714072 1.5703308 0.37140722 -4.1562413 0.18582500 0.23740000 0.03700000 -0.20040000 1.584938e-01 4.519898e-40 FALSE TRUE
ENST00000461701 ENSG00000110046 HEK293_OSMI2_6hA HEK293_TMG_6hB ATG2A protein_coding retained_intron 16.35507 27.84931 8.832644 3.491925 0.6284743 -1.65561 0.4673145 0.5256049 0.6396242 0.1796124 0.07700479 0.2784364 0.03871250 0.02046667 0.07423333 0.05376667 1.166947e-01 4.519898e-40 TRUE FALSE
MSTRG.5688.4 ENSG00000110046 HEK293_OSMI2_6hA HEK293_TMG_6hB ATG2A protein_coding   16.35507 27.84931 8.832644 3.491925 0.6284743 -1.65561 0.7655789 0.0000000 2.5760809 0.0000000 0.24043719 8.0146236 0.08514167 0.00000000 0.29090000 0.29090000 4.519898e-40 4.519898e-40 FALSE TRUE
MSTRG.5688.5 ENSG00000110046 HEK293_OSMI2_6hA HEK293_TMG_6hB ATG2A protein_coding   16.35507 27.84931 8.832644 3.491925 0.6284743 -1.65561 2.9005209 7.8969588 0.0000000 1.2588590 0.00000000 -9.6269791 0.15081667 0.28280000 0.00000000 -0.28280000 1.976585e-19 4.519898e-40 FALSE TRUE
MSTRG.5688.6 ENSG00000110046 HEK293_OSMI2_6hA HEK293_TMG_6hB ATG2A protein_coding   16.35507 27.84931 8.832644 3.491925 0.6284743 -1.65561 1.7270340 2.3933824 1.5555173 0.2902242 0.33055878 -0.6184268 0.12906667 0.08766667 0.17520000 0.08753333 2.952747e-01 4.519898e-40 TRUE TRUE
MSTRG.5688.7 ENSG00000110046 HEK293_OSMI2_6hA HEK293_TMG_6hB ATG2A protein_coding   16.35507 27.84931 8.832644 3.491925 0.6284743 -1.65561 0.6543471 1.5205305 0.0000000 0.7803057 0.00000000 -7.2578880 0.04067500 0.05440000 0.00000000 -0.05440000 4.245343e-01 4.519898e-40 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000110046 E001 6.9646810 0.0053656028 3.626869e-01 0.5978990412 11 64894546 64894571 26 - 0.705 0.890 0.733
ENSG00000110046 E002 57.4656324 0.3681653347 3.177760e-01 0.5577458904 11 64894572 64894684 113 - 1.532 1.733 0.685
ENSG00000110046 E003 60.9636884 0.3835446326 3.120671e-01 0.5524117220 11 64894685 64894702 18 - 1.553 1.759 0.701
ENSG00000110046 E004 91.2228144 0.5152305581 3.184094e-01 0.5583079456 11 64894703 64894732 30 - 1.709 1.934 0.758
ENSG00000110046 E005 121.8629969 0.6006783940 3.009949e-01 0.5414595323 11 64894733 64894778 46 - 1.814 2.062 0.833
ENSG00000110046 E006 325.2175757 1.1354070774 3.202970e-01 0.5599786092 11 64894779 64895209 431 - 2.145 2.499 1.184
ENSG00000110046 E007 158.4604720 0.8013768743 2.238922e-01 0.4580804371 11 64895290 64895442 153 - 1.796 2.193 1.333
ENSG00000110046 E008 165.8511766 0.9001536913 3.225106e-01 0.5619271699 11 64896462 64896616 155 - 1.894 2.203 1.033
ENSG00000110046 E009 142.1331948 0.9054236333 4.098039e-01 0.6358446138 11 64896748 64896847 100 - 1.896 2.125 0.770
ENSG00000110046 E010 92.7899459 0.5284663816 3.034780e-01 0.5440355340 11 64896848 64896869 22 - 1.708 1.943 0.792
ENSG00000110046 E011 5.6515868 0.2308320552 6.563713e-01 0.8075676260 11 64897040 64897411 372 - 0.823 0.749 -0.294
ENSG00000110046 E012 142.2114763 0.8628449051 3.358347e-01 0.5742740223 11 64897412 64897494 83 - 1.848 2.133 0.959
ENSG00000110046 E013 162.4083498 0.0089596691 1.189141e-01 0.3140642809 11 64897671 64897743 73 - 2.031 2.171 0.466
ENSG00000110046 E014 204.4631508 0.0002423080 4.597149e-01 0.6729199965 11 64897839 64897974 136 - 2.181 2.262 0.272
ENSG00000110046 E015 141.3594925 0.0003856287 4.727154e-01 0.6819745391 11 64898086 64898170 85 - 2.017 2.102 0.285
ENSG00000110046 E016 115.6822475 0.0003485655 2.962998e-01 0.5368436155 11 64898261 64898362 102 - 1.984 2.002 0.060
ENSG00000110046 E017 144.3198261 0.0028050055 9.792510e-01 0.9913931688 11 64898636 64898842 207 - 2.046 2.105 0.200
ENSG00000110046 E018 118.3073838 0.0004779599 2.843327e-01 0.5248332190 11 64900494 64900629 136 - 1.926 2.028 0.345
ENSG00000110046 E019 143.7815868 0.0184561491 9.562092e-01 0.9800196258 11 64900884 64901092 209 - 2.046 2.098 0.176
ENSG00000110046 E020 160.4901640 0.0017586587 8.858653e-01 0.9444686444 11 64901962 64902176 215 - 2.095 2.148 0.177
ENSG00000110046 E021 90.8621705 0.0004923505 2.614810e-02 0.1157781842 11 64902260 64902386 127 - 1.764 1.928 0.554
ENSG00000110046 E022 9.5088156 0.0034876670 8.640540e-01 0.9326713131 11 64902510 64902515 6 - 0.933 0.965 0.119
ENSG00000110046 E023 53.6204480 0.0047720353 4.758651e-01 0.6841209250 11 64902516 64902680 165 - 1.583 1.691 0.368
ENSG00000110046 E024 87.8548895 0.0127944143 5.704500e-01 0.7505774171 11 64903288 64903364 77 - 1.860 1.880 0.068
ENSG00000110046 E025 82.1597381 0.0091695994 6.620510e-01 0.8111237709 11 64903590 64903660 71 - 1.777 1.864 0.293
ENSG00000110046 E026 119.1010179 0.0041718776 4.392005e-02 0.1648790577 11 64905563 64905655 93 - 2.036 1.996 -0.137
ENSG00000110046 E027 107.3307993 0.0005100716 8.919747e-03 0.0534633885 11 64905742 64905848 107 - 2.000 1.953 -0.156
ENSG00000110046 E028 84.0702204 0.0069902817 8.742519e-02 0.2590247805 11 64906113 64906193 81 - 1.894 1.852 -0.140
ENSG00000110046 E029 121.9752857 0.0037863666 2.479144e-01 0.4857414834 11 64906334 64906533 200 - 2.019 2.024 0.017
ENSG00000110046 E030 115.8870152 0.0006218463 9.752923e-01 0.9894813814 11 64906665 64906815 151 - 1.952 2.009 0.192
ENSG00000110046 E031 129.1979093 0.0047099226 4.200979e-01 0.6437265354 11 64907255 64907415 161 - 2.027 2.045 0.059
ENSG00000110046 E032 5.3587289 0.0252832183 9.250765e-01 0.9648291125 11 64907416 64907439 24 - 0.706 0.739 0.136
ENSG00000110046 E033 105.3501644 0.0028636266 8.892977e-01 0.9463436686 11 64907525 64907664 140 - 1.916 1.965 0.165
ENSG00000110046 E034 118.4672420 0.0055076517 2.436173e-02 0.1102102368 11 64907748 64907890 143 - 2.050 1.991 -0.195
ENSG00000110046 E035 130.6420928 0.0004581418 6.628635e-06 0.0001470787 11 64908991 64909150 160 - 2.126 2.025 -0.340
ENSG00000110046 E036 89.2210739 0.0006654888 4.593893e-03 0.0324401321 11 64909271 64909367 97 - 1.935 1.869 -0.219
ENSG00000110046 E037 127.0311797 0.0008456394 1.105365e-01 0.2998711575 11 64909681 64909924 244 - 1.937 2.061 0.415
ENSG00000110046 E038 122.2671760 0.0028967330 3.274939e-01 0.5665664769 11 64910040 64910195 156 - 1.937 2.042 0.350
ENSG00000110046 E039 100.5618209 0.0005147567 2.549954e-01 0.4935895366 11 64910616 64910708 93 - 1.931 1.942 0.037
ENSG00000110046 E040 116.2450184 0.0049214399 1.868146e-01 0.4128017741 11 64910807 64910954 148 - 2.005 1.997 -0.028
ENSG00000110046 E041 150.0932950 0.0097365240 1.961355e-02 0.0945882821 11 64911038 64911275 238 - 2.164 2.089 -0.252
ENSG00000110046 E042 92.9319349 0.0025138168 2.879570e-04 0.0036092501 11 64911842 64911982 141 - 1.989 1.880 -0.366
ENSG00000110046 E043 91.4492059 0.0004882623 5.893153e-04 0.0064839195 11 64912085 64912249 165 - 1.966 1.880 -0.289
ENSG00000110046 E044 67.6042563 0.0011652399 1.702762e-02 0.0855729420 11 64912327 64912423 97 - 1.813 1.749 -0.218
ENSG00000110046 E045 3.7729075 0.3168893356 1.456768e-02 0.0764950766 11 64912611 64913037 427 - 1.001 0.382 -2.679
ENSG00000110046 E046 69.4062184 0.0028802372 5.396454e-03 0.0366778384 11 64913038 64913136 99 - 1.846 1.753 -0.317
ENSG00000110046 E047 78.1730311 0.0004957281 3.432961e-04 0.0041700074 11 64913266 64913401 136 - 1.907 1.803 -0.351
ENSG00000110046 E048 21.8830864 0.1571150273 2.267210e-03 0.0188427037 11 64913402 64913820 419 - 1.620 1.105 -1.793
ENSG00000110046 E049 74.5665361 0.0031520311 9.799397e-05 0.0014704984 11 64913821 64913923 103 - 1.914 1.770 -0.484
ENSG00000110046 E050 0.6120945 0.0190495795 8.434056e-01   11 64913924 64914080 157 - 0.199 0.186 -0.122
ENSG00000110046 E051 88.1565606 0.0005978457 9.086214e-06 0.0001931466 11 64914081 64914195 115 - 1.979 1.849 -0.438
ENSG00000110046 E052 46.0029800 0.0008090461 4.954299e-02 0.1785176946 11 64914196 64914208 13 - 1.650 1.591 -0.199
ENSG00000110046 E053 53.6091540 0.0008136954 3.990212e-02 0.1544528003 11 64914209 64914233 25 - 1.713 1.658 -0.188
ENSG00000110046 E054 0.6064850 0.0201624219 3.835928e-01   11 64914234 64914337 104 - 0.000 0.234 9.399
ENSG00000110046 E055 100.0183249 0.0007071161 6.145463e-04 0.0067076353 11 64914338 64914500 163 - 2.000 1.918 -0.274
ENSG00000110046 E056 1.0753476 0.0177130726 4.083698e-02   11 64916937 64916964 28 - 0.522 0.186 -2.121
ENSG00000110046 E057 95.6643936 0.0004124666 1.475503e-05 0.0002939341 11 64916965 64917232 268 - 2.005 1.887 -0.396