ENSG00000110013

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000263593 ENSG00000110013 HEK293_OSMI2_6hA HEK293_TMG_6hB SIAE protein_coding protein_coding 8.848427 7.733035 6.866639 0.2741562 0.1437895 -0.1711956 0.1625362 0.1381870 0.4967897 0.01455317 0.45260928 1.77396812 0.02119583 0.01803333 0.07516667 0.05713333 1.00000000 0.03596615 FALSE TRUE
ENST00000436137 ENSG00000110013 HEK293_OSMI2_6hA HEK293_TMG_6hB SIAE protein_coding retained_intron 8.848427 7.733035 6.866639 0.2741562 0.1437895 -0.1711956 0.6852951 0.3745394 0.4951290 0.05371223 0.13001271 0.39352058 0.07605833 0.04813333 0.07140000 0.02326667 0.78850399 0.03596615 FALSE TRUE
ENST00000545756 ENSG00000110013 HEK293_OSMI2_6hA HEK293_TMG_6hB SIAE protein_coding protein_coding 8.848427 7.733035 6.866639 0.2741562 0.1437895 -0.1711956 6.1418875 4.3767721 4.6132373 0.46897868 0.46476672 0.07574367 0.69480833 0.56423333 0.66953333 0.10530000 0.67174882 0.03596615 FALSE TRUE
MSTRG.6496.3 ENSG00000110013 HEK293_OSMI2_6hA HEK293_TMG_6hB SIAE protein_coding   8.848427 7.733035 6.866639 0.2741562 0.1437895 -0.1711956 1.8545252 2.8435364 1.2614826 0.30372140 0.03486302 -1.16623928 0.20762083 0.36960000 0.18386667 -0.18573333 0.03596615 0.03596615 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000110013 E001 0.4458772 0.0217681645 0.707333982   11 124633113 124635788 2676 - 0.134 0.198 0.680
ENSG00000110013 E002 114.0957500 0.0047423777 0.947505381 0.97606492 11 124635789 124636566 778 - 2.057 2.059 0.005
ENSG00000110013 E003 63.3805330 0.0007127989 0.058826700 0.20013075 11 124636567 124636846 280 - 1.752 1.838 0.291
ENSG00000110013 E004 91.0215318 0.0040228638 0.053365409 0.18760581 11 124636847 124637202 356 - 1.901 1.993 0.308
ENSG00000110013 E005 74.6945030 0.0005803377 0.039167529 0.15260043 11 124638542 124638737 196 - 1.821 1.907 0.290
ENSG00000110013 E006 57.8493112 0.0007897826 0.124560535 0.32303906 11 124639710 124639867 158 - 1.720 1.794 0.249
ENSG00000110013 E007 52.5434905 0.0008890426 0.469675212 0.67980613 11 124647365 124647498 134 - 1.744 1.712 -0.106
ENSG00000110013 E008 44.5560028 0.0010812747 0.866933474 0.93432447 11 124648066 124648175 110 - 1.660 1.655 -0.018
ENSG00000110013 E009 58.7854870 0.0060175363 0.820616481 0.90843021 11 124649619 124649796 178 - 1.764 1.782 0.059
ENSG00000110013 E010 10.3208242 0.0606963470 0.039071000 0.15237116 11 124651815 124652002 188 - 0.830 1.175 1.276
ENSG00000110013 E011 40.7977369 0.0023550288 0.108580723 0.29672219 11 124654655 124654793 139 - 1.661 1.573 -0.298
ENSG00000110013 E012 6.0845774 0.0051014778 0.023099463 0.10626048 11 124658874 124660627 1754 - 0.984 0.703 -1.097
ENSG00000110013 E013 53.5384447 0.0007160154 0.015695107 0.08071804 11 124660628 124660803 176 - 1.789 1.679 -0.372
ENSG00000110013 E014 34.2164498 0.0017001274 0.001719023 0.01515211 11 124669360 124669435 76 - 1.639 1.454 -0.631
ENSG00000110013 E015 29.3639336 0.0060694018 0.019038617 0.09260189 11 124669436 124669521 86 - 1.560 1.394 -0.569
ENSG00000110013 E016 0.0000000       11 124669522 124669612 91 -      
ENSG00000110013 E017 18.9495059 0.0023046724 0.365178061 0.60009516 11 124673642 124673821 180 - 1.326 1.257 -0.242
ENSG00000110013 E018 0.3447487 0.3740599761 0.368220569   11 124675258 124675402 145 - 0.000 0.201 10.963
ENSG00000110013 E019 0.0000000       11 124675571 124675677 107 -      
ENSG00000110013 E020 0.0000000       11 124675678 124675679 2 -      
ENSG00000110013 E021 0.1779838 0.0336242492 0.393992128   11 124676185 124676303 119 - 0.134 0.000 -10.616
ENSG00000110013 E022 0.0000000       11 124694283 124694521 239 -      
ENSG00000110013 E023 0.0000000       11 124695609 124695707 99 -