ENSG00000109919

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000302503 ENSG00000109919 HEK293_OSMI2_6hA HEK293_TMG_6hB MTCH2 protein_coding protein_coding 193.8506 200.0885 148.1746 28.10574 7.724266 -0.433315 14.29751 6.289291 17.78327 1.425521 0.7888022 1.4980705 0.08090417 0.03076667 0.1201333 0.08936667 1.488915e-10 1.488915e-10 FALSE  
MSTRG.5479.12 ENSG00000109919 HEK293_OSMI2_6hA HEK293_TMG_6hB MTCH2 protein_coding   193.8506 200.0885 148.1746 28.10574 7.724266 -0.433315 40.72315 48.075189 32.92054 5.783816 3.1993681 -0.5461663 0.21372500 0.24160000 0.2211000 -0.02050000 7.964613e-01 1.488915e-10 FALSE  
MSTRG.5479.7 ENSG00000109919 HEK293_OSMI2_6hA HEK293_TMG_6hB MTCH2 protein_coding   193.8506 200.0885 148.1746 28.10574 7.724266 -0.433315 59.64420 58.273523 39.37888 9.453107 1.7244939 -0.5652996 0.29936250 0.28966667 0.2681667 -0.02150000 8.880782e-01 1.488915e-10 FALSE  
MSTRG.5479.8 ENSG00000109919 HEK293_OSMI2_6hA HEK293_TMG_6hB MTCH2 protein_coding   193.8506 200.0885 148.1746 28.10574 7.724266 -0.433315 73.64044 82.518161 51.87560 12.805478 2.9996269 -0.6695523 0.37543333 0.41070000 0.3498667 -0.06083333 1.656145e-01 1.488915e-10 FALSE  
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000109919 E001 3.647066 5.485316e-02 5.121570e-01 7.095740e-01 11 47606019 47606095 77 - 0.705 0.589 -0.499
ENSG00000109919 E002 3.386445 1.380479e-02 1.792841e-01 4.030042e-01 11 47606096 47606127 32 - 0.738 0.521 -0.945
ENSG00000109919 E003 6.986435 9.548944e-02 1.040317e-02 5.987996e-02 11 47606128 47606254 127 - 1.118 0.644 -1.831
ENSG00000109919 E004 0.000000       11 47617315 47617316 2 -      
ENSG00000109919 E005 49.997403 4.454645e-02 1.609156e-05 3.172414e-04 11 47617317 47617539 223 - 1.934 1.435 -1.694
ENSG00000109919 E006 356.204680 6.270882e-03 2.275010e-40 3.902515e-37 11 47617540 47618703 1164 - 2.804 2.222 -1.940
ENSG00000109919 E007 650.425098 1.925520e-04 1.375723e-01 3.438002e-01 11 47618704 47618838 135 - 2.787 2.800 0.042
ENSG00000109919 E008 923.755349 5.465821e-04 8.758180e-02 2.592270e-01 11 47618839 47618919 81 - 2.936 2.957 0.068
ENSG00000109919 E009 696.793591 6.789517e-04 1.766949e-01 3.993631e-01 11 47622701 47622710 10 - 2.816 2.833 0.058
ENSG00000109919 E010 1110.516515 9.690005e-05 2.937055e-05 5.297712e-04 11 47622711 47622776 66 - 3.003 3.041 0.125
ENSG00000109919 E011 1057.363625 8.551312e-05 5.065122e-04 5.738320e-03 11 47625674 47625741 68 - 2.987 3.017 0.098
ENSG00000109919 E012 991.030843 7.964270e-05 5.877396e-01 7.621485e-01 11 47627080 47627127 48 - 2.980 2.976 -0.015
ENSG00000109919 E013 1206.901873 8.184765e-05 2.869263e-02 1.234478e-01 11 47628953 47629023 71 - 3.055 3.068 0.043
ENSG00000109919 E014 867.541543 3.349236e-04 7.251585e-01 8.512262e-01 11 47629024 47629046 23 - 2.924 2.920 -0.013
ENSG00000109919 E015 3.140727 2.839086e-01 2.283811e-01 4.633403e-01 11 47629047 47629355 309 - 0.735 0.497 -1.052
ENSG00000109919 E016 1016.188915 1.151840e-04 1.433428e-01 3.524655e-01 11 47630555 47630614 60 - 2.985 2.992 0.024
ENSG00000109919 E017 939.298408 2.846072e-04 2.865714e-01 5.272577e-01 11 47631036 47631087 52 - 2.971 2.947 -0.081
ENSG00000109919 E018 952.280544 3.561891e-04 3.227071e-01 5.620888e-01 11 47631654 47631711 58 - 2.977 2.954 -0.078
ENSG00000109919 E019 960.066295 1.585228e-04 1.636511e-03 1.457221e-02 11 47634672 47634734 63 - 2.996 2.945 -0.167
ENSG00000109919 E020 580.557395 2.673820e-04 1.926472e-01 4.203241e-01 11 47635545 47635571 27 - 2.767 2.735 -0.108
ENSG00000109919 E021 1205.583331 9.550031e-05 6.443912e-01 7.997193e-01 11 47638699 47638805 107 - 3.067 3.061 -0.019
ENSG00000109919 E022 1060.282150 1.191838e-04 3.120630e-02 1.309425e-01 11 47638967 47639051 85 - 2.998 3.013 0.050
ENSG00000109919 E023 651.627331 3.825186e-04 4.293864e-02 1.623739e-01 11 47642379 47642400 22 - 2.783 2.807 0.080
ENSG00000109919 E024 863.498433 9.783541e-05 4.030284e-07 1.281713e-05 11 47642401 47642608 208 - 2.884 2.938 0.182