ENSG00000109805

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000251496 ENSG00000109805 HEK293_OSMI2_6hA HEK293_TMG_6hB NCAPG protein_coding protein_coding 37.21015 8.722305 73.70951 1.667249 4.016882 3.077612 22.156332 6.201678 41.26346 1.2627541 0.7968154 2.732160 0.65302083 0.7063000 0.5619667 -0.1443333 3.658969e-02 4.727467e-20 FALSE TRUE
ENST00000509719 ENSG00000109805 HEK293_OSMI2_6hA HEK293_TMG_6hB NCAPG protein_coding retained_intron 37.21015 8.722305 73.70951 1.667249 4.016882 3.077612 6.300414 0.000000 15.18614 0.0000000 1.9249436 10.569489 0.09962917 0.0000000 0.2047000 0.2047000 4.727467e-20 4.727467e-20 FALSE TRUE
ENST00000510063 ENSG00000109805 HEK293_OSMI2_6hA HEK293_TMG_6hB NCAPG protein_coding protein_coding 37.21015 8.722305 73.70951 1.667249 4.016882 3.077612 6.272199 1.957568 12.91710 0.5434975 1.4193946 2.715913 0.18143750 0.2145667 0.1741667 -0.0404000 7.476745e-01 4.727467e-20 FALSE FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000109805 E001 2.4115759 0.0101919599 7.705371e-01 0.8789878228 4 17810962 17810976 15 + 0.438 0.408 -0.160
ENSG00000109805 E002 3.3590761 0.0097618695 3.915743e-01 0.6216771627 4 17810977 17810978 2 + 0.549 0.408 -0.707
ENSG00000109805 E003 57.3831096 0.0007522845 3.903270e-02 0.1522742322 4 17810979 17811021 43 + 1.640 1.547 -0.315
ENSG00000109805 E004 65.7299106 0.0008044521 4.807097e-02 0.1751497894 4 17811022 17811027 6 + 1.696 1.618 -0.264
ENSG00000109805 E005 152.9380120 0.0025064575 2.204373e-03 0.0184319342 4 17811028 17811188 161 + 2.057 1.959 -0.328
ENSG00000109805 E006 258.1409089 0.0017768562 1.664896e-04 0.0022947615 4 17812221 17812424 204 + 2.281 2.188 -0.313
ENSG00000109805 E007 352.3421019 0.0021223557 3.182119e-04 0.0039138526 4 17812917 17813145 229 + 2.414 2.336 -0.261
ENSG00000109805 E008 0.5117739 0.0242927438 4.311052e-01   4 17813146 17813346 201 + 0.103 0.250 1.542
ENSG00000109805 E009 271.7362440 0.0015038408 1.826244e-05 0.0003536353 4 17814853 17814998 146 + 2.305 2.197 -0.362
ENSG00000109805 E010 164.6712709 0.0008482024 3.165908e-05 0.0005655740 4 17815274 17815358 85 + 2.091 1.961 -0.437
ENSG00000109805 E011 25.1014593 0.1208364673 2.778789e-01 0.5179479275 4 17817196 17817231 36 + 1.298 1.144 -0.545
ENSG00000109805 E012 14.2784891 0.0033996307 8.328418e-01 0.9154058366 4 17817232 17817260 29 + 1.037 1.103 0.241
ENSG00000109805 E013 282.7237097 0.0006141762 2.135670e-05 0.0004042420 4 17817261 17817453 193 + 2.320 2.230 -0.299
ENSG00000109805 E014 257.5285378 0.0014247124 7.002638e-04 0.0074455859 4 17817939 17818088 150 + 2.278 2.204 -0.247
ENSG00000109805 E015 281.2141230 0.0002479878 6.515660e-06 0.0001449448 4 17822983 17823123 141 + 2.319 2.228 -0.304
ENSG00000109805 E016 2.4940408 0.0806790819 3.204230e-01 0.5600690561 4 17823124 17823147 24 + 0.461 0.251 -1.278
ENSG00000109805 E017 131.5659661 0.0012854002 3.432301e-02 0.1397400206 4 17823647 17823671 25 + 1.987 1.937 -0.170
ENSG00000109805 E018 148.9989728 0.0014363386 3.737483e-01 0.6071457978 4 17823672 17823698 27 + 2.031 2.040 0.032
ENSG00000109805 E019 210.7970470 0.0048835715 9.012275e-02 0.2640174296 4 17823699 17823770 72 + 2.185 2.152 -0.111
ENSG00000109805 E020 234.9388303 0.0043114952 9.070592e-02 0.2650780519 4 17824968 17825057 90 + 2.231 2.203 -0.094
ENSG00000109805 E021 309.6430054 0.0010253328 1.725267e-02 0.0863717025 4 17825382 17825561 180 + 2.351 2.323 -0.093
ENSG00000109805 E022 5.0265062 0.0105650861 6.280833e-01 0.7893107281 4 17825562 17825567 6 + 0.664 0.614 -0.214
ENSG00000109805 E023 223.6938953 0.0031768039 8.052053e-01 0.8992807559 4 17828278 17828388 111 + 2.197 2.254 0.192
ENSG00000109805 E024 263.7963680 0.0042032336 3.090088e-01 0.5495067276 4 17830997 17831116 120 + 2.262 2.350 0.293
ENSG00000109805 E025 375.4379100 0.0002414442 4.859038e-02 0.1763612004 4 17834299 17834523 225 + 2.416 2.510 0.314
ENSG00000109805 E026 363.2480519 0.0018516639 3.084270e-02 0.1298735258 4 17837159 17837340 182 + 2.397 2.512 0.383
ENSG00000109805 E027 444.7603208 0.0032575629 1.486569e-01 0.3603699147 4 17837627 17837801 175 + 2.488 2.585 0.323
ENSG00000109805 E028 359.5893361 0.0006441439 7.391534e-03 0.0465080575 4 17839676 17839837 162 + 2.392 2.509 0.390
ENSG00000109805 E029 267.2629207 0.0078452228 1.147979e-02 0.0643133823 4 17840071 17840209 139 + 2.254 2.424 0.567
ENSG00000109805 E030 194.7016698 0.0772233852 4.611873e-02 0.1702909391 4 17840607 17840693 87 + 2.092 2.368 0.922
ENSG00000109805 E031 178.7041727 1.5868657626 3.899536e-01 0.6204362241 4 17842310 17842379 70 + 2.034 2.388 1.184
ENSG00000109805 E032 247.4854337 1.7056497959 4.431033e-01 0.6608066497 4 17843302 17844865 1564 + 2.188 2.491 1.010