ENSG00000109787

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000261438 ENSG00000109787 HEK293_OSMI2_6hA HEK293_TMG_6hB KLF3 protein_coding protein_coding 6.253714 3.419736 9.997489 0.7529956 0.3429318 1.544911 5.2525045 2.053862 9.3322492 0.3554785 0.5046199 2.178423 0.7675958 0.6201333 0.93423333 0.3141000 0.04963226 0.04963226 FALSE TRUE
MSTRG.24737.1 ENSG00000109787 HEK293_OSMI2_6hA HEK293_TMG_6hB KLF3 protein_coding   6.253714 3.419736 9.997489 0.7529956 0.3429318 1.544911 0.8076732 1.072786 0.5105212 0.3994464 0.5105212 -1.056719 0.1924667 0.2913000 0.04966667 -0.2416333 0.18122806 0.04963226 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000109787 E001 0.000000       4 38663894 38663943 50 +      
ENSG00000109787 E002 2.328475 0.0097791831 0.0588013654 0.200064598 4 38664184 38664196 13 + 0.406 0.678 1.283
ENSG00000109787 E003 2.387477 0.0255303429 0.0376601340 0.148733882 4 38664197 38664198 2 + 0.405 0.717 1.446
ENSG00000109787 E004 7.516391 0.1066597282 0.0021183374 0.017863937 4 38664199 38664343 145 + 0.692 1.173 1.826
ENSG00000109787 E005 14.317873 0.3815324831 0.1035714560 0.288155359 4 38664344 38664461 118 + 1.017 1.360 1.220
ENSG00000109787 E006 34.705274 0.0358083570 0.4111234382 0.636908871 4 38680587 38680682 96 + 1.518 1.550 0.111
ENSG00000109787 E007 0.000000       4 38680683 38680985 303 +      
ENSG00000109787 E008 105.178336 0.0007643163 0.0841786909 0.253142301 4 38688585 38689071 487 + 1.998 2.009 0.037
ENSG00000109787 E009 54.470862 0.0022493452 0.2369302932 0.473038839 4 38689729 38689879 151 + 1.713 1.723 0.035
ENSG00000109787 E010 3.018335 0.0086308523 0.0014190838 0.013035281 4 38689880 38690751 872 + 0.367 0.823 2.091
ENSG00000109787 E011 64.635778 0.0007516360 0.0344234759 0.140014801 4 38694746 38694906 161 + 1.777 1.822 0.153
ENSG00000109787 E012 710.530536 0.0080504757 0.0002893099 0.003621662 4 38697082 38701517 4436 + 2.857 2.747 -0.367