ENSG00000109775

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000264689 ENSG00000109775 HEK293_OSMI2_6hA HEK293_TMG_6hB UFSP2 protein_coding protein_coding 15.52213 8.074272 20.80628 2.411524 1.024439 1.364522 1.222014 0.2861213 1.701627 0.1296288 0.2198720 2.5311082 0.08099167 0.03123333 0.08270000 0.05146667 2.792884e-01 8.794944e-10 FALSE TRUE
ENST00000502282 ENSG00000109775 HEK293_OSMI2_6hA HEK293_TMG_6hB UFSP2 protein_coding processed_transcript 15.52213 8.074272 20.80628 2.411524 1.024439 1.364522 2.863817 0.0000000 4.733575 0.0000000 1.2975741 8.8898309 0.13730833 0.00000000 0.22596667 0.22596667 8.794944e-10 8.794944e-10 FALSE TRUE
ENST00000502428 ENSG00000109775 HEK293_OSMI2_6hA HEK293_TMG_6hB UFSP2 protein_coding nonsense_mediated_decay 15.52213 8.074272 20.80628 2.411524 1.024439 1.364522 0.991075 0.6157909 1.740629 0.6157909 0.9153392 1.4841206 0.05327500 0.05326667 0.08443333 0.03116667 7.770468e-01 8.794944e-10 TRUE TRUE
ENST00000509180 ENSG00000109775 HEK293_OSMI2_6hA HEK293_TMG_6hB UFSP2 protein_coding protein_coding 15.52213 8.074272 20.80628 2.411524 1.024439 1.364522 3.084597 2.2431455 3.971558 0.4760367 0.8319869 0.8213924 0.23446667 0.32183333 0.19170000 -0.13013333 6.497833e-01 8.794944e-10 FALSE FALSE
ENST00000510755 ENSG00000109775 HEK293_OSMI2_6hA HEK293_TMG_6hB UFSP2 protein_coding nonsense_mediated_decay 15.52213 8.074272 20.80628 2.411524 1.024439 1.364522 4.174591 2.7801204 4.850070 1.0433200 0.1437855 0.8006498 0.28676667 0.35426667 0.23476667 -0.11950000 7.021537e-01 8.794944e-10 TRUE TRUE
ENST00000511485 ENSG00000109775 HEK293_OSMI2_6hA HEK293_TMG_6hB UFSP2 protein_coding protein_coding 15.52213 8.074272 20.80628 2.411524 1.024439 1.364522 2.918630 1.8636064 3.537334 0.7621199 0.9095041 0.9209173 0.18886250 0.21243333 0.16653333 -0.04590000 8.216344e-01 8.794944e-10 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000109775 E001 0.1426347 0.0342853722 0.93338401   4 185399537 185399539 3 - 0.095 0.000 -9.700
ENSG00000109775 E002 8.1696662 0.4824627579 0.83801179 0.91832456 4 185399540 185400314 775 - 1.010 0.841 -0.638
ENSG00000109775 E003 1.4967186 0.1737719845 0.35226030 0.58929443 4 185400315 185400333 19 - 0.469 0.263 -1.226
ENSG00000109775 E004 1.4473901 0.1370279568 0.66294704 0.81172312 4 185400334 185400337 4 - 0.430 0.351 -0.448
ENSG00000109775 E005 30.7759272 0.7169049298 0.47477481 0.68340127 4 185400338 185400478 141 - 1.429 1.573 0.495
ENSG00000109775 E006 1.0241679 0.0153787590 0.28882313   4 185402262 185402344 83 - 0.348 0.154 -1.529
ENSG00000109775 E007 65.3709989 0.0342230845 0.28176431 0.52208988 4 185403494 185403618 125 - 1.775 1.865 0.303
ENSG00000109775 E008 60.7715594 0.0054488733 0.04457946 0.16655840 4 185405780 185405856 77 - 1.734 1.843 0.368
ENSG00000109775 E009 3.2525110 0.1043761979 0.52335542 0.71736380 4 185405857 185405959 103 - 0.567 0.685 0.512
ENSG00000109775 E010 1.8976912 0.1031557661 0.96854454 0.98611526 4 185405960 185406168 209 - 0.436 0.435 -0.004
ENSG00000109775 E011 78.0865457 0.0152657444 0.38997480 0.62044401 4 185407936 185408060 125 - 1.858 1.916 0.194
ENSG00000109775 E012 71.8461173 0.0125566172 0.83241393 0.91519385 4 185408271 185408390 120 - 1.845 1.847 0.007
ENSG00000109775 E013 43.7996652 0.0014798430 0.45332045 0.66821956 4 185408391 185408435 45 - 1.650 1.612 -0.130
ENSG00000109775 E014 69.8687119 0.0050826327 0.01393767 0.07409486 4 185413726 185413872 147 - 1.884 1.753 -0.443
ENSG00000109775 E015 59.6632088 0.0076146975 0.24165803 0.47845050 4 185415155 185415283 129 - 1.799 1.725 -0.247
ENSG00000109775 E016 43.3225518 0.0052595912 0.67204504 0.81761115 4 185415284 185415347 64 - 1.646 1.627 -0.066
ENSG00000109775 E017 42.4830879 0.0009965951 0.63248047 0.79194946 4 185415710 185415779 70 - 1.617 1.650 0.111
ENSG00000109775 E018 39.0994666 0.0009780482 0.10198574 0.28535295 4 185415780 185415810 31 - 1.557 1.654 0.332
ENSG00000109775 E019 31.1741878 0.0011907415 0.45797372 0.67173198 4 185415811 185415815 5 - 1.480 1.532 0.181
ENSG00000109775 E020 36.7475260 0.0009597069 0.24820752 0.48602894 4 185415816 185415867 52 - 1.539 1.611 0.248
ENSG00000109775 E021 48.0138010 0.0007728313 0.39523563 0.62452988 4 185418441 185418507 67 - 1.693 1.654 -0.130
ENSG00000109775 E022 0.1723744 0.2100800258 0.28550836   4 185418508 185418513 6 - 0.000 0.154 11.258
ENSG00000109775 E023 38.4931620 0.0024246246 0.92429010 0.96449912 4 185418587 185418611 25 - 1.586 1.587 0.005
ENSG00000109775 E024 73.9818915 0.0150868498 0.16398406 0.38261616 4 185418612 185418770 159 - 1.890 1.814 -0.256
ENSG00000109775 E025 44.1861919 0.0108582004 0.28298898 0.52343298 4 185422485 185422553 69 - 1.663 1.599 -0.218
ENSG00000109775 E026 28.4665870 0.0055965375 0.81022759 0.90236473 4 185422554 185422563 10 - 1.459 1.448 -0.036
ENSG00000109775 E027 0.0000000       4 185422564 185422564 1 -      
ENSG00000109775 E028 27.4671695 0.0030457590 0.92533956 0.96487053 4 185425866 185425979 114 - 1.436 1.449 0.047