ENSG00000109685

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000503991 ENSG00000109685 HEK293_OSMI2_6hA HEK293_TMG_6hB NSD2 protein_coding scaRNA 47.42338 52.79609 56.36636 0.5133036 4.745044 0.09438589 2.808045 1.709761 9.045657 1.7097612 5.2615544 2.3966110 0.0503250 0.03296667 0.1489333 0.1159667 5.998568e-01 7.390906e-31   FALSE
ENST00000508803 ENSG00000109685 HEK293_OSMI2_6hA HEK293_TMG_6hB NSD2 protein_coding protein_coding 47.42338 52.79609 56.36636 0.5133036 4.745044 0.09438589 17.757622 23.197085 16.791434 2.8706697 1.1941760 -0.4659809 0.3802833 0.43856667 0.3000000 -0.1385667 3.420860e-01 7.390906e-31 FALSE TRUE
ENST00000509115 ENSG00000109685 HEK293_OSMI2_6hA HEK293_TMG_6hB NSD2 protein_coding protein_coding 47.42338 52.79609 56.36636 0.5133036 4.745044 0.09438589 4.892615 0.000000 10.739933 0.0000000 1.0184798 10.0701120 0.0955500 0.00000000 0.1929333 0.1929333 7.390906e-31 7.390906e-31 FALSE TRUE
ENST00000677895 ENSG00000109685 HEK293_OSMI2_6hA HEK293_TMG_6hB NSD2 protein_coding protein_coding 47.42338 52.79609 56.36636 0.5133036 4.745044 0.09438589 4.950832 7.817904 2.270165 0.6859645 0.3358343 -1.7794876 0.1139958 0.14790000 0.0420000 -0.1059000 9.141707e-04 7.390906e-31 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000109685 E001 0.6064850 0.0203134161 1.022441e-01   4 1871393 1871410 18 + 0.000 0.303 10.738
ENSG00000109685 E002 0.6064850 0.0203134161 1.022441e-01   4 1871411 1871413 3 + 0.000 0.303 12.615
ENSG00000109685 E003 0.6064850 0.0203134161 1.022441e-01   4 1871414 1871433 20 + 0.000 0.303 12.615
ENSG00000109685 E004 0.7788594 0.0493867097 6.323963e-02   4 1871434 1871442 9 + 0.000 0.355 12.598
ENSG00000109685 E005 1.6487984 0.0111598587 3.951168e-03 2.887260e-02 4 1871443 1871447 5 + 0.000 0.548 14.144
ENSG00000109685 E006 1.9105347 0.0105343496 1.457943e-03 1.332190e-02 4 1871448 1871448 1 + 0.000 0.606 14.421
ENSG00000109685 E007 6.1747019 0.0245005616 6.204724e-01 7.841291e-01 4 1871449 1871453 5 + 0.804 0.877 0.284
ENSG00000109685 E008 14.1671851 0.0025912386 2.615068e-01 5.005847e-01 4 1871454 1871460 7 + 1.097 1.202 0.375
ENSG00000109685 E009 57.0697156 0.0007335319 6.936191e-02 2.234854e-01 4 1871461 1871542 82 + 1.805 1.717 -0.298
ENSG00000109685 E010 2.6946388 0.2782814818 6.005044e-01 7.705424e-01 4 1887501 1887690 190 + 0.427 0.613 0.889
ENSG00000109685 E011 4.5064237 0.0055670441 9.095197e-01 9.568785e-01 4 1892166 1892169 4 + 0.742 0.725 -0.070
ENSG00000109685 E012 16.4695296 0.0225923094 4.072378e-01 6.339255e-01 4 1892170 1892263 94 + 1.163 1.258 0.336
ENSG00000109685 E013 1.2314435 0.0177093478 1.683237e-01   4 1892782 1892844 63 + 0.150 0.402 1.889
ENSG00000109685 E014 0.6730019 0.0193874923 6.349734e-01   4 1892845 1892891 47 + 0.261 0.178 -0.700
ENSG00000109685 E015 14.6592726 0.0296057111 9.532091e-01 9.785689e-01 4 1893730 1893909 180 + 1.184 1.188 0.013
ENSG00000109685 E016 0.0000000       4 1899218 1899220 3 +      
ENSG00000109685 E017 3.4579827 0.0075433254 1.689444e-01 3.891674e-01 4 1899221 1899395 175 + 0.485 0.704 0.981
ENSG00000109685 E018 1.5277596 0.1181762429 6.347665e-03 4.144322e-02 4 1900619 1900625 7 + 0.637 0.098 -3.716
ENSG00000109685 E019 60.6965782 0.0006071556 2.255324e-02 1.044125e-01 4 1900626 1900636 11 + 1.840 1.734 -0.360
ENSG00000109685 E020 67.0277264 0.0007131719 2.251754e-03 1.874416e-02 4 1900637 1900649 13 + 1.898 1.761 -0.461
ENSG00000109685 E021 606.8273552 0.0009113654 1.396581e-13 1.686854e-11 4 1900650 1901251 602 + 2.857 2.707 -0.498
ENSG00000109685 E022 373.7490757 0.0022513030 2.886760e-10 1.855557e-08 4 1904216 1904378 163 + 2.666 2.481 -0.616
ENSG00000109685 E023 6.6815618 0.0065120122 3.138859e-01 5.541167e-01 4 1912091 1912194 104 + 0.945 0.818 -0.485
ENSG00000109685 E024 406.1528176 0.0002430924 8.059241e-16 1.374774e-13 4 1916871 1917037 167 + 2.683 2.531 -0.507
ENSG00000109685 E025 489.5694019 0.0012581518 2.724771e-05 4.962239e-04 4 1918141 1918431 291 + 2.734 2.636 -0.326
ENSG00000109685 E026 366.7436997 0.0009926632 2.490361e-04 3.209536e-03 4 1918432 1918623 192 + 2.604 2.516 -0.292
ENSG00000109685 E027 5.4767123 0.0388574848 8.275681e-01 9.123848e-01 4 1918624 1919187 564 + 0.829 0.797 -0.125
ENSG00000109685 E028 319.4174975 0.0002426735 5.286011e-05 8.728960e-04 4 1930626 1930729 104 + 2.542 2.456 -0.287
ENSG00000109685 E029 237.1609538 0.0003796885 1.287989e-02 6.995687e-02 4 1930730 1930770 41 + 2.400 2.337 -0.210
ENSG00000109685 E030 354.4877462 0.0001811616 9.920887e-03 5.781329e-02 4 1935144 1935262 119 + 2.569 2.516 -0.174
ENSG00000109685 E031 0.8688415 0.1495589278 3.395969e-01   4 1938404 1938450 47 + 0.149 0.349 1.595
ENSG00000109685 E032 249.7972786 0.0015591161 9.800282e-01 9.918138e-01 4 1938451 1938532 82 + 2.387 2.387 -0.002
ENSG00000109685 E033 3.4853373 0.0797518343 7.362179e-01 8.580989e-01 4 1939281 1939653 373 + 0.591 0.659 0.295
ENSG00000109685 E034 142.8346127 0.0029341373 4.559439e-01 6.702202e-01 4 1939654 1939660 7 + 2.127 2.155 0.093
ENSG00000109685 E035 226.6928016 0.0012044211 2.580313e-01 4.967468e-01 4 1939661 1939751 91 + 2.323 2.355 0.105
ENSG00000109685 E036 148.5947782 0.0004427408 5.115751e-01 7.091844e-01 4 1939752 1939778 27 + 2.174 2.153 -0.072
ENSG00000109685 E037 95.4322773 0.0004275911 2.625765e-20 8.078175e-18 4 1939779 1941334 1556 + 2.150 1.808 -1.147
ENSG00000109685 E038 36.7708796 0.0031095327 2.374081e-05 4.420534e-04 4 1941335 1942338 1004 + 1.705 1.438 -0.911
ENSG00000109685 E039 24.9672587 0.0013126706 1.247026e-02 6.832730e-02 4 1942339 1942432 94 + 1.503 1.327 -0.606
ENSG00000109685 E040 29.9582485 0.0012652416 1.599976e-01 3.767956e-01 4 1942433 1942565 133 + 1.530 1.437 -0.320
ENSG00000109685 E041 246.2645831 0.0149012906 9.347872e-01 9.695900e-01 4 1942566 1948818 6253 + 2.378 2.379 0.005
ENSG00000109685 E042 288.2447393 0.0002256582 6.825757e-01 8.243351e-01 4 1951072 1951203 132 + 2.452 2.442 -0.035
ENSG00000109685 E043 3.0445196 0.1656036141 9.220960e-01 9.633239e-01 4 1951999 1952104 106 + 0.591 0.604 0.058
ENSG00000109685 E044 1.9018000 0.4848706720 6.285034e-01 7.896108e-01 4 1952105 1952107 3 + 0.358 0.490 0.707
ENSG00000109685 E045 238.0809403 0.0002182500 7.666381e-01 8.765836e-01 4 1952108 1952231 124 + 2.369 2.360 -0.028
ENSG00000109685 E046 43.2057533 0.1236944272 2.671679e-01 5.067983e-01 4 1952752 1953117 366 + 1.715 1.573 -0.482
ENSG00000109685 E047 18.4355697 0.1272846371 6.559475e-02 2.152227e-01 4 1953118 1953187 70 + 1.445 1.121 -1.140
ENSG00000109685 E048 25.4740480 0.1154668257 1.472361e-01 3.583667e-01 4 1953188 1953323 136 + 1.523 1.323 -0.689
ENSG00000109685 E049 317.1148625 0.0001724915 1.272847e-02 6.936279e-02 4 1953324 1953524 201 + 2.522 2.469 -0.176
ENSG00000109685 E050 1.0293295 0.0160239029 8.049800e-01   4 1953814 1953982 169 + 0.261 0.304 0.303
ENSG00000109685 E051 3.2865472 0.2633090938 9.337545e-01 9.689662e-01 4 1954537 1954685 149 + 0.591 0.636 0.198
ENSG00000109685 E052 185.2567710 0.0059723780 1.495191e-01 3.615806e-01 4 1955161 1955226 66 + 2.298 2.231 -0.225
ENSG00000109685 E053 251.5850812 0.0031941443 3.994931e-01 6.278775e-01 4 1955227 1955340 114 + 2.409 2.378 -0.102
ENSG00000109685 E054 2.2904107 0.0166932008 7.314310e-01 8.550674e-01 4 1955579 1955692 114 + 0.540 0.481 -0.283
ENSG00000109685 E055 293.5323958 0.0002683550 8.151217e-01 9.052977e-01 4 1955693 1955849 157 + 2.460 2.453 -0.022
ENSG00000109685 E056 198.0050913 0.0003004551 5.811380e-01 7.578991e-01 4 1955983 1956086 104 + 2.293 2.276 -0.054
ENSG00000109685 E057 219.0560876 0.0017718032 8.694959e-01 9.355958e-01 4 1956087 1956188 102 + 2.325 2.329 0.014
ENSG00000109685 E058 240.0518075 0.0009711201 4.972663e-01 6.990956e-01 4 1957933 1958036 104 + 2.357 2.374 0.057
ENSG00000109685 E059 3.5577509 0.1242446865 5.560024e-01 7.405095e-01 4 1959296 1959470 175 + 0.540 0.690 0.658
ENSG00000109685 E060 365.9268153 0.0004360743 3.733673e-01 6.067891e-01 4 1959471 1959617 147 + 2.561 2.541 -0.067
ENSG00000109685 E061 373.6507511 0.0002158493 9.426534e-01 9.736181e-01 4 1959618 1959740 123 + 2.561 2.558 -0.009
ENSG00000109685 E062 390.8739442 0.0001521692 5.905845e-01 7.641082e-01 4 1961035 1961151 117 + 2.572 2.581 0.029
ENSG00000109685 E063 1.8496950 0.0236379762 1.622874e-01 3.801964e-01 4 1974633 1974635 3 + 0.261 0.517 1.475
ENSG00000109685 E064 52.5373147 0.0080867538 4.984833e-01 6.997580e-01 4 1974636 1974786 151 + 1.687 1.732 0.150
ENSG00000109685 E065 48.7588403 0.0020536019 6.083834e-01 7.758258e-01 4 1974787 1974862 76 + 1.668 1.695 0.092
ENSG00000109685 E066 532.8157756 0.0001751181 6.640013e-01 8.123704e-01 4 1974863 1975004 142 + 2.710 2.716 0.020
ENSG00000109685 E067 464.5315788 0.0001290102 7.949107e-01 8.932727e-01 4 1975294 1975400 107 + 2.657 2.651 -0.019
ENSG00000109685 E068 1.3517283 0.6562429153 5.602723e-01   4 1975401 1975646 246 + 0.428 0.311 -0.679
ENSG00000109685 E069 1.9745938 0.0414776856 3.726977e-01 6.062107e-01 4 1976353 1976474 122 + 0.350 0.516 0.881
ENSG00000109685 E070 561.6254287 0.0001985372 1.047635e-04 1.555446e-03 4 1976475 1976679 205 + 2.695 2.758 0.209
ENSG00000109685 E071 3197.0392250 0.0001077228 6.757597e-97 1.434494e-92 4 1978638 1982207 3570 + 3.394 3.540 0.483