ENSG00000109572

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000347613 ENSG00000109572 HEK293_OSMI2_6hA HEK293_TMG_6hB CLCN3 protein_coding protein_coding 24.95542 7.934836 46.01238 1.35976 1.41434 2.534246 3.075461 1.7711171 4.033401 0.3547064 0.3126665 1.182787 0.16064583 0.22090000 0.08756667 -0.13333333 7.335772e-05 6.182498e-09 FALSE TRUE
ENST00000360642 ENSG00000109572 HEK293_OSMI2_6hA HEK293_TMG_6hB CLCN3 protein_coding protein_coding 24.95542 7.934836 46.01238 1.35976 1.41434 2.534246 1.204074 0.0000000 4.775752 0.0000000 0.8157632 8.902602 0.02807500 0.00000000 0.10503333 0.10503333 6.182498e-09 6.182498e-09 FALSE TRUE
ENST00000507875 ENSG00000109572 HEK293_OSMI2_6hA HEK293_TMG_6hB CLCN3 protein_coding protein_coding 24.95542 7.934836 46.01238 1.35976 1.41434 2.534246 2.707084 0.6918491 5.408531 0.2140308 0.1954420 2.948669 0.07977917 0.08650000 0.11753333 0.03103333 7.039034e-01 6.182498e-09 FALSE TRUE
ENST00000511092 ENSG00000109572 HEK293_OSMI2_6hA HEK293_TMG_6hB CLCN3 protein_coding protein_coding 24.95542 7.934836 46.01238 1.35976 1.41434 2.534246 6.371315 1.1033879 13.654128 0.6437335 0.9328936 3.617365 0.16533333 0.13436667 0.29606667 0.16170000 7.125891e-01 6.182498e-09 FALSE FALSE
ENST00000513761 ENSG00000109572 HEK293_OSMI2_6hA HEK293_TMG_6hB CLCN3 protein_coding protein_coding 24.95542 7.934836 46.01238 1.35976 1.41434 2.534246 7.872735 3.4732511 11.827119 0.7401942 1.1584053 1.764812 0.42548750 0.43270000 0.25606667 -0.17663333 1.419970e-01 6.182498e-09 FALSE TRUE
MSTRG.25723.9 ENSG00000109572 HEK293_OSMI2_6hA HEK293_TMG_6hB CLCN3 protein_coding   24.95542 7.934836 46.01238 1.35976 1.41434 2.534246 1.867508 0.4056534 4.172270 0.1646772 0.7002044 3.330833 0.06719583 0.05333333 0.09136667 0.03803333 6.630922e-01 6.182498e-09 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000109572 E001 0.0000000       4 169612633 169612677 45 +      
ENSG00000109572 E002 1.3662264 0.1647002682 0.963409874   4 169620526 169620528 3 + 0.330 0.352 0.136
ENSG00000109572 E003 8.8355063 0.0053609269 0.424334403 0.64682209 4 169620529 169620551 23 + 0.877 0.997 0.453
ENSG00000109572 E004 25.4413210 0.0022522448 0.663791698 0.81228948 4 169620552 169620577 26 + 1.334 1.318 -0.056
ENSG00000109572 E005 41.5431523 0.0011563166 0.068926802 0.22261994 4 169620578 169620595 18 + 1.559 1.454 -0.362
ENSG00000109572 E006 98.4488020 0.0005667275 0.009268954 0.05497439 4 169620596 169620682 87 + 1.926 1.828 -0.330
ENSG00000109572 E007 105.7562294 0.0004083962 0.017007132 0.08548265 4 169620683 169620751 69 + 1.954 1.871 -0.277
ENSG00000109572 E008 79.8718307 0.0007711117 0.209170469 0.44089575 4 169620752 169620771 20 + 1.823 1.781 -0.141
ENSG00000109572 E009 71.9177037 0.0036733935 0.360016227 0.59574026 4 169620772 169620788 17 + 1.777 1.743 -0.117
ENSG00000109572 E010 197.7226161 0.0045714379 0.370321210 0.60422275 4 169620789 169621063 275 + 2.211 2.188 -0.077
ENSG00000109572 E011 6.6162165 0.0048886083 0.911176546 0.95777875 4 169630165 169630335 171 + 0.794 0.829 0.136
ENSG00000109572 E012 99.6155827 0.0004845986 0.313906710 0.55411671 4 169635913 169635982 70 + 1.916 1.893 -0.077
ENSG00000109572 E013 144.0359531 0.0003501490 0.523563999 0.71749912 4 169635983 169636088 106 + 2.071 2.069 -0.006
ENSG00000109572 E014 3.9557862 0.0065274128 0.516148297 0.71235038 4 169638597 169638742 146 + 0.646 0.550 -0.427
ENSG00000109572 E015 0.2922838 0.0263623322 0.337214824   4 169642708 169643168 461 + 0.066 0.214 1.965
ENSG00000109572 E016 8.9094335 0.0036160905 0.218324864 0.45142633 4 169660062 169660448 387 + 0.938 0.786 -0.585
ENSG00000109572 E017 96.4638360 0.0006833395 0.140774053 0.34870620 4 169680050 169680067 18 + 1.906 1.860 -0.155
ENSG00000109572 E018 197.8279061 0.0005974854 0.361640057 0.59702334 4 169680068 169680207 140 + 2.210 2.202 -0.027
ENSG00000109572 E019 0.9217543 0.0160322351 0.500428691   4 169680379 169680731 353 + 0.218 0.357 0.964
ENSG00000109572 E020 187.0339881 0.0002744824 0.026131085 0.11572980 4 169687658 169687757 100 + 2.193 2.143 -0.169
ENSG00000109572 E021 221.0233075 0.0002662253 0.019866767 0.09541116 4 169689043 169689230 188 + 2.265 2.217 -0.159
ENSG00000109572 E022 115.4530336 0.0004140321 0.320134492 0.55987601 4 169690530 169690652 123 + 1.978 1.959 -0.065
ENSG00000109572 E023 173.5572387 0.0002661820 0.663956100 0.81234432 4 169692114 169692320 207 + 2.143 2.179 0.118
ENSG00000109572 E024 71.2104629 0.0005407665 0.169092746 0.38940953 4 169695612 169695630 19 + 1.748 1.837 0.299
ENSG00000109572 E025 101.8168600 0.0004462246 0.520293054 0.71512871 4 169695631 169695692 62 + 1.911 1.959 0.162
ENSG00000109572 E026 108.2078322 0.0004477094 0.499434733 0.70039890 4 169697189 169697279 91 + 1.947 1.940 -0.024
ENSG00000109572 E027 105.9250672 0.0005048579 0.179526759 0.40338200 4 169697280 169697360 81 + 1.944 1.907 -0.122
ENSG00000109572 E028 289.8236123 0.0005369858 0.231532376 0.46693510 4 169697361 169697734 374 + 2.373 2.363 -0.035
ENSG00000109572 E029 190.3570625 0.0002916585 0.502699567 0.70263626 4 169703998 169704184 187 + 2.181 2.223 0.140
ENSG00000109572 E030 325.2300554 0.0002477848 0.444678228 0.66191528 4 169706868 169707266 399 + 2.413 2.453 0.132
ENSG00000109572 E031 234.2449347 0.0004736249 0.410952224 0.63677965 4 169713079 169713295 217 + 2.270 2.316 0.152
ENSG00000109572 E032 22.0261567 0.0016445460 0.152547653 0.36598291 4 169717792 169717867 76 + 1.239 1.380 0.493
ENSG00000109572 E033 7.3765073 0.0161951537 0.010890905 0.06190468 4 169717868 169717934 67 + 0.896 0.465 -1.843
ENSG00000109572 E034 9.4110041 0.0032608450 0.026669599 0.11727182 4 169717935 169718101 167 + 0.984 0.684 -1.176
ENSG00000109572 E035 1041.9544700 0.0061028844 0.016668519 0.08424748 4 169719907 169723673 3767 + 2.903 3.008 0.347