ENSG00000109189

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000441222 ENSG00000109189 HEK293_OSMI2_6hA HEK293_TMG_6hB USP46 protein_coding protein_coding 8.137991 3.589238 13.7377 0.8738075 0.6403057 1.933427 0.7897693 0.4183507 0.9487048 0.03402278 0.04620437 1.162294 0.12455417 0.1288000 0.06910000 -0.05970000 3.592515e-01 3.161671e-05 FALSE TRUE
ENST00000451218 ENSG00000109189 HEK293_OSMI2_6hA HEK293_TMG_6hB USP46 protein_coding protein_coding 8.137991 3.589238 13.7377 0.8738075 0.6403057 1.933427 4.2767564 2.3593455 7.0955200 0.55807099 0.35965294 1.584452 0.56817917 0.6594333 0.51640000 -0.14303333 3.570936e-01 3.161671e-05 FALSE TRUE
MSTRG.24873.5 ENSG00000109189 HEK293_OSMI2_6hA HEK293_TMG_6hB USP46 protein_coding   8.137991 3.589238 13.7377 0.8738075 0.6403057 1.933427 2.2214511 0.7063115 4.2628936 0.27522325 0.55605343 2.576554 0.21980417 0.1906667 0.30800000 0.11733333 4.238504e-01 3.161671e-05 FALSE TRUE
MSTRG.24873.6 ENSG00000109189 HEK293_OSMI2_6hA HEK293_TMG_6hB USP46 protein_coding   8.137991 3.589238 13.7377 0.8738075 0.6403057 1.933427 0.6774711 0.0000000 1.2718523 0.00000000 0.20441313 7.002086 0.05765833 0.0000000 0.09443333 0.09443333 3.161671e-05 3.161671e-05 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000109189 E001 0.7389688 0.018002895 0.631778400   4 52590960 52591026 67 - 0.240 0.194 -0.394
ENSG00000109189 E002 5.4359531 0.016747412 0.009278245 0.05500604 4 52591027 52591372 346 - 0.615 1.065 1.765
ENSG00000109189 E003 19.9529525 0.285881883 0.102668758 0.28653744 4 52591373 52592713 1341 - 1.135 1.511 1.313
ENSG00000109189 E004 15.7373356 0.214606723 0.111380129 0.30128395 4 52592714 52594177 1464 - 1.053 1.399 1.223
ENSG00000109189 E005 280.0365138 1.535332766 0.425634376 0.64775075 4 52594178 52596813 2636 - 2.301 2.574 0.907
ENSG00000109189 E006 56.5740610 0.652549161 0.279753427 0.51984091 4 52596814 52596989 176 - 1.613 1.888 0.931
ENSG00000109189 E007 97.2047061 1.110161351 0.453569254 0.66838535 4 52596990 52597466 477 - 1.869 2.077 0.701
ENSG00000109189 E008 42.7066912 0.599552580 0.435013737 0.65498607 4 52597467 52597580 114 - 1.541 1.684 0.487
ENSG00000109189 E009 43.2111426 0.590475389 0.402559878 0.63042589 4 52597581 52597741 161 - 1.534 1.711 0.603
ENSG00000109189 E010 1.6606734 0.013760270 0.011387483 0.06395405 4 52598569 52598627 59 - 0.481 0.000 -10.800
ENSG00000109189 E011 38.3952511 0.001222347 0.036298869 0.14504089 4 52598628 52598706 79 - 1.550 1.534 -0.057
ENSG00000109189 E012 63.6427211 0.022988223 0.071733350 0.22828344 4 52601857 52602054 198 - 1.755 1.744 -0.038
ENSG00000109189 E013 43.1528683 0.067956511 0.136759811 0.34255105 4 52604501 52604584 84 - 1.599 1.544 -0.187
ENSG00000109189 E014 44.1963467 0.069150276 0.269091061 0.50886209 4 52610541 52610617 77 - 1.595 1.598 0.010
ENSG00000109189 E015 44.5931598 0.088413424 0.183037747 0.40786774 4 52626018 52626092 75 - 1.605 1.585 -0.071
ENSG00000109189 E016 34.8099118 0.059897873 0.189304394 0.41611123 4 52626093 52626127 35 - 1.500 1.486 -0.049
ENSG00000109189 E017 50.9055889 0.053322590 0.184729861 0.41014772 4 52626128 52626247 120 - 1.656 1.666 0.033
ENSG00000109189 E018 54.0376895 0.054041645 0.215231992 0.44780141 4 52627950 52628060 111 - 1.680 1.690 0.033
ENSG00000109189 E019 55.6409762 0.038126036 0.032070625 0.13342634 4 52628061 52628163 103 - 1.714 1.624 -0.305
ENSG00000109189 E020 0.0000000       4 52628164 52628366 203 -      
ENSG00000109189 E021 0.6316833 0.043134480 0.845034351   4 52629634 52629685 52 - 0.192 0.193 0.014
ENSG00000109189 E022 36.5152611 0.074427538 0.054891878 0.19110093 4 52631064 52631108 45 - 1.545 1.417 -0.439
ENSG00000109189 E023 28.9088475 0.103030527 0.109989389 0.29899235 4 52631109 52631144 36 - 1.446 1.318 -0.443
ENSG00000109189 E024 0.0000000       4 52650971 52651088 118 -      
ENSG00000109189 E025 0.0000000       4 52655295 52655422 128 -      
ENSG00000109189 E026 0.0000000       4 52656296 52656452 157 -      
ENSG00000109189 E027 0.0000000       4 52656453 52656572 120 -      
ENSG00000109189 E028 0.0000000       4 52656573 52656590 18 -      
ENSG00000109189 E029 6.3276368 0.250934973 0.366318999 0.60095335 4 52658174 52658281 108 - 0.835 0.761 -0.293
ENSG00000109189 E030 38.5841068 0.075396537 0.088491939 0.26098673 4 52659115 52659301 187 - 1.564 1.455 -0.373