ENSG00000109107

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000226253 ENSG00000109107 HEK293_OSMI2_6hA HEK293_TMG_6hB ALDOC protein_coding protein_coding 8.431233 12.86722 4.351455 2.275673 0.1934705 -1.561939 7.44822786 11.725880 3.4888155 2.2894282 0.253743891 -1.745988 0.86974583 0.9035 0.80070000 -0.10280000 3.414145e-01 1.118963e-07 FALSE  
ENST00000395321 ENSG00000109107 HEK293_OSMI2_6hA HEK293_TMG_6hB ALDOC protein_coding protein_coding 8.431233 12.86722 4.351455 2.275673 0.1934705 -1.561939 0.68869882 1.009947 0.3140785 0.1031726 0.176509006 -1.654079 0.07841667 0.0819 0.06910000 -0.01280000 8.766338e-01 1.118963e-07 FALSE  
ENST00000435638 ENSG00000109107 HEK293_OSMI2_6hA HEK293_TMG_6hB ALDOC protein_coding protein_coding 8.431233 12.86722 4.351455 2.275673 0.1934705 -1.561939 0.03800638 0.000000 0.2414822 0.0000000 0.141716625 4.652385 0.00900000 0.0000 0.05840000 0.05840000 1.500020e-01 1.118963e-07 FALSE  
ENST00000460201 ENSG00000109107 HEK293_OSMI2_6hA HEK293_TMG_6hB ALDOC protein_coding protein_coding 8.431233 12.86722 4.351455 2.275673 0.1934705 -1.561939 0.07378638 0.000000 0.2335074 0.0000000 0.009493294 4.605893 0.01253750 0.0000 0.05383333 0.05383333 1.118963e-07 1.118963e-07 FALSE  
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000109107 E001 0.0000000       17 28573115 28573119 5 -      
ENSG00000109107 E002 119.7474703 0.0304399553 0.135629825 0.34077116 17 28573120 28573621 502 - 1.888 2.011 0.413
ENSG00000109107 E003 90.1697131 0.0007456966 0.036511637 0.14563064 17 28573735 28573934 200 - 1.778 1.890 0.379
ENSG00000109107 E004 74.3505358 0.0207080062 0.265687128 0.50509107 17 28574067 28574241 175 - 1.711 1.802 0.309
ENSG00000109107 E005 51.8345780 0.0023715256 0.069666202 0.22412570 17 28574494 28574577 84 - 1.531 1.664 0.455
ENSG00000109107 E006 36.4086506 0.0011647063 0.197938308 0.42708693 17 28574696 28574709 14 - 1.399 1.509 0.377
ENSG00000109107 E007 32.6385503 0.0013749781 0.072667892 0.23013600 17 28574710 28574713 4 - 1.315 1.472 0.544
ENSG00000109107 E008 50.1259190 0.0011281272 0.416941431 0.64134716 17 28574714 28574787 74 - 1.651 1.619 -0.108
ENSG00000109107 E009 53.0158095 0.0010582271 0.016537719 0.08377036 17 28574788 28574856 69 - 1.735 1.618 -0.397
ENSG00000109107 E010 38.6142024 0.0012721845 0.093847861 0.27085288 17 28574952 28574963 12 - 1.584 1.491 -0.319
ENSG00000109107 E011 40.8292354 0.0012259968 0.035004291 0.14160057 17 28574964 28574978 15 - 1.625 1.509 -0.397
ENSG00000109107 E012 44.1168874 0.0060932050 0.087101279 0.25845382 17 28574979 28575006 28 - 1.645 1.546 -0.337
ENSG00000109107 E013 0.4812263 0.0212848909 0.566361103   17 28575007 28575122 116 - 0.214 0.123 -0.956
ENSG00000109107 E014 94.3875725 0.0012409680 0.027048134 0.11845526 17 28575123 28575334 212 - 1.950 1.868 -0.275
ENSG00000109107 E015 44.7807141 0.0122463134 0.534251190 0.72510592 17 28575421 28575496 76 - 1.524 1.580 0.193
ENSG00000109107 E016 32.1394218 0.0107834545 0.683767986 0.82511693 17 28575497 28575544 48 - 1.451 1.422 -0.101
ENSG00000109107 E017 1.4700451 0.0119767902 0.002820095 0.02231555 17 28575545 28575914 370 - 0.682 0.174 -2.949
ENSG00000109107 E018 4.1843772 0.0123347650 0.725329543 0.85135732 17 28575965 28576017 53 - 0.682 0.632 -0.213
ENSG00000109107 E019 1.7273893 0.0118187605 0.882870263 0.94278849 17 28576018 28576020 3 - 0.356 0.394 0.218
ENSG00000109107 E020 0.8315845 0.3557587101 0.433591798   17 28576021 28576279 259 - 0.361 0.173 -1.403
ENSG00000109107 E021 0.6653672 0.2314949971 0.241502462   17 28576280 28576424 145 - 0.356 0.125 -1.934
ENSG00000109107 E022 29.8655744 0.0197406838 0.947669508 0.97615702 17 28576801 28576948 148 - 1.399 1.396 -0.013