ENSG00000109066

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000335464 ENSG00000109066 HEK293_OSMI2_6hA HEK293_TMG_6hB TMEM104 protein_coding protein_coding 21.25334 32.96393 10.71695 3.727197 0.3230839 -1.620086 14.067945 22.966604 7.3960210 2.7816599 0.3571432 -1.633395 0.68185833 0.69530000 0.69143333 -0.003866667 1.000000e+00 2.137722e-09 FALSE TRUE
ENST00000578764 ENSG00000109066 HEK293_OSMI2_6hA HEK293_TMG_6hB TMEM104 protein_coding protein_coding 21.25334 32.96393 10.71695 3.727197 0.3230839 -1.620086 1.188638 2.046839 0.6076167 0.3702057 0.2481534 -1.735645 0.06062083 0.06223333 0.05636667 -0.005866667 9.338318e-01 2.137722e-09 FALSE FALSE
ENST00000582773 ENSG00000109066 HEK293_OSMI2_6hA HEK293_TMG_6hB TMEM104 protein_coding protein_coding 21.25334 32.96393 10.71695 3.727197 0.3230839 -1.620086 1.640961 2.684348 1.1329848 0.3415264 0.2786465 -1.237130 0.08631250 0.08116667 0.10443333 0.023266667 8.035776e-01 2.137722e-09 FALSE TRUE
MSTRG.15040.11 ENSG00000109066 HEK293_OSMI2_6hA HEK293_TMG_6hB TMEM104 protein_coding   21.25334 32.96393 10.71695 3.727197 0.3230839 -1.620086 2.062921 2.025195 0.0000000 0.4287121 0.0000000 -7.669023 0.06499583 0.05990000 0.00000000 -0.059900000 2.137722e-09 2.137722e-09 FALSE FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000109066 E001 0.7263945 0.0247800008 1.000000000   17 74776486 74776496 11 + 0.212 0.220 0.068
ENSG00000109066 E002 1.6058348 0.2865825992 0.515350149 0.71188259 17 74776497 74776498 2 + 0.466 0.348 -0.643
ENSG00000109066 E003 1.7367029 0.3393178945 0.564207092 0.74627771 17 74776499 74776499 1 + 0.466 0.374 -0.498
ENSG00000109066 E004 3.6895516 0.0135207792 0.976143983 0.98985908 17 74776500 74776508 9 + 0.618 0.615 -0.009
ENSG00000109066 E005 16.2389709 0.0025424303 0.627998099 0.78922905 17 74776509 74776519 11 + 1.112 1.163 0.182
ENSG00000109066 E006 50.6398143 0.0125044466 0.092763562 0.26889795 17 74776520 74776577 58 + 1.504 1.651 0.499
ENSG00000109066 E007 46.9978735 0.0098858603 0.070972213 0.22666129 17 74777264 74777266 3 + 1.468 1.620 0.520
ENSG00000109066 E008 99.1944287 0.0031810221 0.039990175 0.15469469 17 74777267 74777375 109 + 1.823 1.931 0.366
ENSG00000109066 E009 1.7301657 0.0200236084 0.836710101 0.91765556 17 74777578 74777738 161 + 0.354 0.395 0.237
ENSG00000109066 E010 114.3290861 0.0003963855 0.441210938 0.65959282 17 74785482 74785603 122 + 1.999 1.967 -0.105
ENSG00000109066 E011 2.1535731 0.2833813735 0.060281670 0.20345842 17 74785604 74785680 77 + 0.738 0.302 -2.156
ENSG00000109066 E012 20.3368866 0.0557478354 0.722231601 0.84945742 17 74788747 74788788 42 + 1.282 1.227 -0.195
ENSG00000109066 E013 108.6868880 0.0042490081 0.047998146 0.17499332 17 74788789 74788870 82 + 2.030 1.928 -0.341
ENSG00000109066 E014 141.3421350 0.0021561900 0.041334940 0.15819973 17 74790200 74790296 97 + 2.130 2.043 -0.289
ENSG00000109066 E015 107.8381426 0.0044752757 0.067090961 0.21860300 17 74790956 74791036 81 + 2.022 1.928 -0.315
ENSG00000109066 E016 127.9655706 0.0003576733 0.006486416 0.04213044 17 74795012 74795111 100 + 2.099 1.998 -0.336
ENSG00000109066 E017 77.2391684 0.0007346628 0.003967352 0.02896842 17 74795524 74795526 3 + 1.907 1.771 -0.458
ENSG00000109066 E018 153.7175074 0.0003887596 0.028808087 0.12381120 17 74795527 74795632 106 + 2.157 2.082 -0.252
ENSG00000109066 E019 1.5484778 0.0140571812 0.442060931 0.66010810 17 74798262 74798325 64 + 0.212 0.367 1.078
ENSG00000109066 E020 140.5904312 0.0013250824 0.442599110 0.66045200 17 74819750 74819843 94 + 2.083 2.050 -0.110
ENSG00000109066 E021 328.8627617 0.0002403752 0.288309016 0.52905616 17 74835927 74836497 571 + 2.409 2.432 0.079
ENSG00000109066 E022 323.5727465 0.0035609452 0.883586322 0.94315594 17 74836498 74837098 601 + 2.429 2.418 -0.037
ENSG00000109066 E023 180.0414432 0.0002924095 0.963141377 0.98352037 17 74837099 74837353 255 + 2.169 2.169 0.002
ENSG00000109066 E024 187.6096017 0.0006105074 0.082713733 0.25011920 17 74837354 74837589 236 + 2.138 2.195 0.190
ENSG00000109066 E025 685.3712937 0.0001216727 0.094106409 0.27136387 17 74837590 74838886 1297 + 2.727 2.752 0.083
ENSG00000109066 E026 478.3398717 0.0002327523 0.005226314 0.03581134 17 74838887 74839795 909 + 2.547 2.602 0.182
ENSG00000109066 E027 2.1084827 0.1645758077 0.282443984 0.52285296 17 74849273 74849344 72 + 0.620 0.366 -1.264