ENSG00000108671

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000261712 ENSG00000108671 HEK293_OSMI2_6hA HEK293_TMG_6hB PSMD11 protein_coding protein_coding 57.68868 55.22834 61.31964 7.542839 2.971521 0.1509144 23.802905 26.412840 15.703489 4.311250 0.9197182 -0.7497819 0.41632083 0.4747333 0.25733333 -0.21740000 0.0000183998 1.83998e-05 FALSE TRUE
ENST00000457654 ENSG00000108671 HEK293_OSMI2_6hA HEK293_TMG_6hB PSMD11 protein_coding protein_coding 57.68868 55.22834 61.31964 7.542839 2.971521 0.1509144 9.390213 11.842830 8.138509 1.379855 0.1052643 -0.5406235 0.16510417 0.2156000 0.13323333 -0.08236667 0.0009360103 1.83998e-05 FALSE TRUE
ENST00000578397 ENSG00000108671 HEK293_OSMI2_6hA HEK293_TMG_6hB PSMD11 protein_coding retained_intron 57.68868 55.22834 61.31964 7.542839 2.971521 0.1509144 6.150880 1.107580 12.186530 0.761618 0.3372848 3.4480212 0.10468750 0.0247000 0.19936667 0.17466667 0.2112382947 1.83998e-05 FALSE TRUE
ENST00000649012 ENSG00000108671 HEK293_OSMI2_6hA HEK293_TMG_6hB PSMD11 protein_coding protein_coding 57.68868 55.22834 61.31964 7.542839 2.971521 0.1509144 3.718630 3.517989 2.869359 0.689886 1.3426514 -0.2930984 0.06362083 0.0631000 0.04503333 -0.01806667 0.7862276965 1.83998e-05 FALSE TRUE
MSTRG.14119.5 ENSG00000108671 HEK293_OSMI2_6hA HEK293_TMG_6hB PSMD11 protein_coding   57.68868 55.22834 61.31964 7.542839 2.971521 0.1509144 12.574324 10.069755 20.520394 2.574331 1.3548759 1.0263007 0.21290000 0.1761000 0.33420000 0.15810000 0.0219698584 1.83998e-05 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000108671 E001 0.6966548 0.1882321403 9.930330e-01   17 32444379 32444460 82 + 0.240 0.259 0.140
ENSG00000108671 E002 0.8690291 0.0294835415 6.617765e-01   17 32444461 32444473 13 + 0.241 0.325 0.589
ENSG00000108671 E003 41.8858932 0.5253492685 2.503007e-01 4.882753e-01 17 32444474 32444503 30 + 1.461 1.720 0.884
ENSG00000108671 E004 43.6479618 0.5424167384 2.579430e-01 4.966796e-01 17 32444504 32444504 1 + 1.481 1.736 0.867
ENSG00000108671 E005 57.1862786 0.6745473382 3.644892e-01 5.994464e-01 17 32444505 32444509 5 + 1.644 1.830 0.629
ENSG00000108671 E006 61.7037241 0.7409458863 4.641594e-01 6.759649e-01 17 32444510 32444511 2 + 1.723 1.838 0.387
ENSG00000108671 E007 89.0098940 0.8459193216 4.469784e-01 6.634260e-01 17 32444512 32444518 7 + 1.864 2.003 0.468
ENSG00000108671 E008 252.4342760 1.4679939356 5.505800e-01 7.367513e-01 17 32444519 32444614 96 + 2.315 2.452 0.454
ENSG00000108671 E009 0.6071052 0.0198114019 4.778402e-01   17 32445667 32445987 321 + 0.137 0.265 1.180
ENSG00000108671 E010 373.8640598 0.0928353487 6.110737e-01 7.776558e-01 17 32446945 32447046 102 + 2.548 2.584 0.119
ENSG00000108671 E011 0.3503582 0.0330764998 8.231540e-01   17 32447047 32447333 287 + 0.137 0.107 -0.405
ENSG00000108671 E012 434.9988660 0.0026596963 2.027463e-01 4.329962e-01 17 32454495 32454619 125 + 2.648 2.624 -0.082
ENSG00000108671 E013 2.0386082 0.0437703903 1.981020e-01 4.272360e-01 17 32454752 32454877 126 + 0.599 0.379 -1.095
ENSG00000108671 E014 335.4312031 0.0012394666 1.030787e-03 1.014731e-02 17 32464049 32464120 72 + 2.558 2.490 -0.228
ENSG00000108671 E015 286.7320446 0.0010747673 8.143016e-05 1.260134e-03 17 32464521 32464578 58 + 2.498 2.411 -0.289
ENSG00000108671 E016 373.0872664 0.0017413226 1.075884e-04 1.589611e-03 17 32468999 32469071 73 + 2.613 2.525 -0.291
ENSG00000108671 E017 452.2039758 0.0012538020 1.119941e-03 1.081864e-02 17 32469072 32469193 122 + 2.682 2.622 -0.200
ENSG00000108671 E018 572.7625620 0.0001541872 3.549985e-09 1.840260e-07 17 32473801 32473945 145 + 2.794 2.715 -0.260
ENSG00000108671 E019 2.6682732 0.0105785187 8.509013e-06 1.824067e-04 17 32473946 32474081 136 + 0.841 0.107 -4.401
ENSG00000108671 E020 442.3724249 0.0001404587 3.161276e-05 5.649347e-04 17 32474764 32474824 61 + 2.671 2.611 -0.199
ENSG00000108671 E021 30.6914809 0.1731023204 5.723646e-01 7.519529e-01 17 32476680 32477520 841 + 1.508 1.486 -0.075
ENSG00000108671 E022 424.2747946 0.0003630657 5.758843e-03 3.853821e-02 17 32477521 32477583 63 + 2.642 2.602 -0.130
ENSG00000108671 E023 3.2921567 0.3522247023 9.262469e-01 9.652376e-01 17 32477584 32477829 246 + 0.604 0.643 0.171
ENSG00000108671 E024 540.9148103 0.0018002043 5.481887e-03 3.711802e-02 17 32479251 32479376 126 + 2.754 2.705 -0.164
ENSG00000108671 E025 20.5053771 0.0734531570 7.326569e-01 8.557770e-01 17 32479377 32479850 474 + 1.337 1.320 -0.059
ENSG00000108671 E026 345.5889998 0.0082631508 2.506224e-01 4.886493e-01 17 32479851 32479886 36 + 2.548 2.521 -0.089
ENSG00000108671 E027 10.1264807 0.3486869815 7.682419e-01 8.775722e-01 17 32479887 32480077 191 + 0.977 1.086 0.399
ENSG00000108671 E028 6.8812157 0.2152189927 9.639882e-01 9.839063e-01 17 32480078 32480145 68 + 0.875 0.909 0.130
ENSG00000108671 E029 389.3396736 0.0041325539 1.651947e-01 3.842074e-01 17 32480146 32480191 46 + 2.598 2.572 -0.086
ENSG00000108671 E030 277.1813611 0.0046151873 2.725883e-01 5.124398e-01 17 32480192 32480197 6 + 2.448 2.427 -0.070
ENSG00000108671 E031 5.0022901 0.2816520245 7.511340e-01 8.674660e-01 17 32480198 32480488 291 + 0.672 0.826 0.623
ENSG00000108671 E032 605.0890545 0.0039520971 7.807527e-01 8.851703e-01 17 32480489 32480631 143 + 2.767 2.782 0.052
ENSG00000108671 E033 84.8330290 0.0005168294 2.335215e-03 1.928389e-02 17 32480632 32480752 121 + 1.841 1.975 0.453
ENSG00000108671 E034 855.5012988 0.0011914585 1.549746e-02 7.994610e-02 17 32480753 32481310 558 + 2.887 2.952 0.216
ENSG00000108671 E035 1480.5324863 0.0004969577 2.630635e-32 2.552814e-29 17 32481311 32483319 2009 + 3.059 3.227 0.558