ENSG00000108669

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000361101 ENSG00000108669 HEK293_OSMI2_6hA HEK293_TMG_6hB CYTH1 protein_coding protein_coding 16.22823 21.90623 11.72681 0.2279526 0.228635 -0.9009591 5.3109089 7.4691241 3.582008 0.5048386 0.2487759 -1.058079 0.32923750 0.3407000 0.30560000 -0.03510000 0.84164718 0.04709663 FALSE TRUE
ENST00000446868 ENSG00000108669 HEK293_OSMI2_6hA HEK293_TMG_6hB CYTH1 protein_coding protein_coding 16.22823 21.90623 11.72681 0.2279526 0.228635 -0.9009591 5.2028590 7.4691241 3.582008 0.5048386 0.2487759 -1.058079 0.32160833 0.3407000 0.30560000 -0.03510000 0.84164718 0.04709663 FALSE TRUE
ENST00000586299 ENSG00000108669 HEK293_OSMI2_6hA HEK293_TMG_6hB CYTH1 protein_coding retained_intron 16.22823 21.90623 11.72681 0.2279526 0.228635 -0.9009591 1.8383533 2.9627190 0.771438 0.7397212 0.3867149 -1.927580 0.10838333 0.1355667 0.06453333 -0.07103333 0.74221234 0.04709663 FALSE FALSE
ENST00000591455 ENSG00000108669 HEK293_OSMI2_6hA HEK293_TMG_6hB CYTH1 protein_coding protein_coding 16.22823 21.90623 11.72681 0.2279526 0.228635 -0.9009591 1.7636947 2.3932331 1.490521 0.2540839 0.3378873 -0.679513 0.11026667 0.1093000 0.12623333 0.01693333 0.93482905 0.04709663 FALSE TRUE
MSTRG.15182.10 ENSG00000108669 HEK293_OSMI2_6hA HEK293_TMG_6hB CYTH1 protein_coding   16.22823 21.90623 11.72681 0.2279526 0.228635 -0.9009591 0.8084309 0.6589283 1.588529 0.2106753 0.4277298 1.256822 0.05938333 0.0302000 0.13683333 0.10663333 0.04709663 0.04709663 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000108669 E001 0.3447487 0.3710473793 0.822152316   17 78674048 78674048 1 - 0.000 0.159 15.339
ENSG00000108669 E002 606.1577371 1.3988643218 0.381204586 0.61319995 17 78674049 78675655 1607 - 2.515 2.823 1.023
ENSG00000108669 E003 94.3357322 0.4782803106 0.317975802 0.55790806 17 78675656 78675819 164 - 1.780 2.003 0.751
ENSG00000108669 E004 53.3853100 0.2840432887 0.305998965 0.54665152 17 78675820 78675847 28 - 1.547 1.757 0.712
ENSG00000108669 E005 82.4710514 0.4577121985 0.361696881 0.59705100 17 78675848 78675962 115 - 1.750 1.937 0.631
ENSG00000108669 E006 110.5267610 0.5524491242 0.346087436 0.58363892 17 78675963 78676118 156 - 1.864 2.066 0.680
ENSG00000108669 E007 84.5470310 0.4605832340 0.356688286 0.59309746 17 78676119 78676169 51 - 1.757 1.949 0.647
ENSG00000108669 E008 57.0784338 0.2611089768 0.176294361 0.39884415 17 78676170 78676994 825 - 1.482 1.808 1.107
ENSG00000108669 E009 13.2170456 0.1017483743 0.317552378 0.55750171 17 78676995 78677050 56 - 0.906 1.191 1.042
ENSG00000108669 E010 79.6415345 0.4587798306 0.318931501 0.55865998 17 78677051 78678471 1421 - 1.645 1.945 1.015
ENSG00000108669 E011 63.1828638 0.3736612669 0.387334313 0.61838454 17 78680190 78680218 29 - 1.653 1.818 0.558
ENSG00000108669 E012 124.6230963 0.6171420914 0.402835961 0.63061901 17 78680219 78680344 126 - 1.938 2.111 0.581
ENSG00000108669 E013 103.8429340 0.0051283492 0.875533225 0.93902791 17 78680971 78681042 72 - 1.917 2.014 0.325
ENSG00000108669 E014 0.5778428 0.1292092140 0.420615534   17 78681043 78681066 24 - 0.000 0.222 15.923
ENSG00000108669 E015 108.8707025 0.0005395709 0.003171064 0.02443817 17 78692417 78692493 77 - 2.015 2.001 -0.048
ENSG00000108669 E016 49.7758510 0.0082926270 0.061453750 0.20603846 17 78692494 78692495 2 - 1.688 1.667 -0.070
ENSG00000108669 E017 3.7542107 0.0075275096 0.937771941 0.97113370 17 78696007 78696009 3 - 0.587 0.673 0.374
ENSG00000108669 E018 49.6883266 0.0033306084 0.065060744 0.21402725 17 78698268 78698268 1 - 1.679 1.670 -0.033
ENSG00000108669 E019 117.1562040 0.0271134059 0.039766537 0.15412800 17 78698269 78698380 112 - 2.074 2.021 -0.176
ENSG00000108669 E020 145.0806730 0.0532150650 0.058472025 0.19935144 17 78698820 78698968 149 - 2.188 2.101 -0.291
ENSG00000108669 E021 100.0057869 0.0598026026 0.124878936 0.32355282 17 78700331 78700391 61 - 2.013 1.949 -0.215
ENSG00000108669 E022 79.5773404 0.0635909434 0.237448083 0.47362163 17 78700392 78700443 52 - 1.889 1.864 -0.087
ENSG00000108669 E023 48.0171944 0.0426238092 0.332189027 0.57101409 17 78701671 78701671 1 - 1.646 1.660 0.048
ENSG00000108669 E024 70.5504985 0.0059904915 0.063231120 0.20997103 17 78701672 78701751 80 - 1.822 1.819 -0.008
ENSG00000108669 E025 75.6265420 0.0513618040 0.160648317 0.37774887 17 78702122 78702240 119 - 1.879 1.836 -0.144
ENSG00000108669 E026 79.7566883 0.0481874073 0.048669080 0.17651857 17 78702538 78702604 67 - 1.940 1.839 -0.342
ENSG00000108669 E027 86.1336765 0.0306781878 0.039928112 0.15450740 17 78708197 78708261 65 - 1.952 1.884 -0.228
ENSG00000108669 E028 0.8866948 0.0185246192 0.750617184   17 78708912 78709350 439 - 0.170 0.273 0.870
ENSG00000108669 E029 0.8923043 0.5564408125 0.637759207   17 78709351 78709649 299 - 0.298 0.224 -0.547
ENSG00000108669 E030 73.6046449 0.0427794165 0.046978301 0.17250840 17 78709650 78709732 83 - 1.900 1.808 -0.309
ENSG00000108669 E031 0.1779838 0.1156936068 0.172138990   17 78716929 78717025 97 - 0.170 0.000 -16.612
ENSG00000108669 E032 0.3503582 0.0563351471 0.453501428   17 78723213 78723395 183 - 0.170 0.086 -1.132
ENSG00000108669 E033 0.1779838 0.1156936068 0.172138990   17 78723396 78723750 355 - 0.170 0.000 -16.612
ENSG00000108669 E034 0.0000000       17 78723893 78724046 154 -      
ENSG00000108669 E035 0.6120945 0.0223723980 1.000000000   17 78727658 78727965 308 - 0.170 0.218 0.448
ENSG00000108669 E036 6.7713599 0.2362907856 0.136681632 0.34243497 17 78736692 78736967 276 - 1.030 0.751 -1.066
ENSG00000108669 E037 41.2708289 0.0389438656 0.267731125 0.50738051 17 78782202 78782297 96 - 1.601 1.590 -0.040