ENSG00000108604

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000323347 ENSG00000108604 HEK293_OSMI2_6hA HEK293_TMG_6hB SMARCD2 protein_coding protein_coding 104.5804 157.6038 59.81863 21.26193 1.211947 -1.397486 13.44245 17.9094 20.00780 2.177761 0.8540681 0.1597606 0.1754792 0.1169333 0.3342000 0.2172667 4.542566e-06 4.542566e-06 FALSE TRUE
ENST00000448276 ENSG00000108604 HEK293_OSMI2_6hA HEK293_TMG_6hB SMARCD2 protein_coding protein_coding 104.5804 157.6038 59.81863 21.26193 1.211947 -1.397486 81.85199 124.1741 34.71652 22.343667 0.8000061 -1.8383709 0.7316458 0.7764667 0.5803667 -0.1961000 4.349285e-02 4.542566e-06 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000108604 E001 1370.058383 3.004608e-04 3.034001e-10 1.940032e-08 17 63832081 63832501 421 - 2.988 3.076 0.293
ENSG00000108604 E002 946.912188 4.432923e-04 1.962806e-08 8.619849e-07 17 63832502 63832603 102 - 2.821 2.918 0.323
ENSG00000108604 E003 603.943487 1.429528e-04 3.652272e-05 6.380412e-04 17 63832604 63832638 35 - 2.642 2.718 0.253
ENSG00000108604 E004 1681.067218 7.379250e-05 1.248340e-03 1.177873e-02 17 63832639 63832991 353 - 3.120 3.155 0.116
ENSG00000108604 E005 1004.373805 9.270582e-05 3.891459e-01 6.198318e-01 17 63833069 63833170 102 - 2.932 2.921 -0.037
ENSG00000108604 E006 1195.143505 1.373062e-04 1.506509e-05 2.994381e-04 17 63833298 63833420 123 - 3.039 2.985 -0.180
ENSG00000108604 E007 1052.881615 1.085984e-04 4.175583e-04 4.902586e-03 17 63833587 63833704 118 - 2.978 2.932 -0.153
ENSG00000108604 E008 511.575888 2.993438e-04 3.919590e-04 4.652926e-03 17 63833705 63833722 18 - 2.685 2.616 -0.229
ENSG00000108604 E009 397.628367 8.769170e-04 1.929465e-02 9.349083e-02 17 63833909 63833911 3 - 2.567 2.509 -0.196
ENSG00000108604 E010 762.311429 5.246837e-04 6.906610e-02 2.229130e-01 17 63833912 63834006 95 - 2.830 2.796 -0.114
ENSG00000108604 E011 379.740424 6.669660e-04 8.604967e-01 9.306001e-01 17 63834167 63834177 11 - 2.500 2.503 0.012
ENSG00000108604 E012 949.522993 6.954791e-04 5.147842e-01 7.115074e-01 17 63834178 63834328 151 - 2.909 2.895 -0.047
ENSG00000108604 E013 1.905613 8.690964e-02 7.838867e-01 8.868818e-01 17 63834362 63834473 112 - 0.445 0.385 -0.323
ENSG00000108604 E014 717.484849 1.822234e-04 4.318085e-01 6.525966e-01 17 63834474 63834575 102 - 2.787 2.774 -0.043
ENSG00000108604 E015 722.619998 7.865542e-04 9.469692e-02 2.724144e-01 17 63834705 63834800 96 - 2.806 2.770 -0.119
ENSG00000108604 E016 11.981647 9.297863e-02 3.653816e-01 6.002569e-01 17 63834801 63835145 345 - 1.156 0.997 -0.579
ENSG00000108604 E017 656.650133 2.725684e-03 5.741677e-01 7.531408e-01 17 63835412 63835490 79 - 2.750 2.733 -0.057
ENSG00000108604 E018 697.447900 1.943893e-03 1.836535e-01 4.086829e-01 17 63835491 63835567 77 - 2.790 2.754 -0.118
ENSG00000108604 E019 10.671707 2.034354e-01 7.843806e-01 8.871460e-01 17 63835568 63835657 90 - 0.995 0.992 -0.013
ENSG00000108604 E020 14.937683 1.182229e-01 1.449171e-01 3.548499e-01 17 63836746 63836921 176 - 1.305 1.060 -0.874
ENSG00000108604 E021 872.597681 1.256541e-04 1.943605e-03 1.669039e-02 17 63836922 63837044 123 - 2.896 2.852 -0.147
ENSG00000108604 E022 1.616601 3.635217e-01 9.986210e-01 1.000000e+00 17 63837146 63837194 49 - 0.342 0.379 0.223
ENSG00000108604 E023 521.420786 1.078943e-03 6.340053e-02 2.103479e-01 17 63837195 63837237 43 - 2.673 2.630 -0.142
ENSG00000108604 E024 613.740896 1.796348e-03 8.124282e-01 9.036659e-01 17 63837441 63837625 185 - 2.704 2.712 0.025
ENSG00000108604 E025 5.771716 1.055173e-01 7.986615e-01 8.955427e-01 17 63838610 63838728 119 - 0.715 0.773 0.234
ENSG00000108604 E026 4.914961 8.350096e-03 6.750279e-01 8.195757e-01 17 63842381 63842458 78 - 0.661 0.728 0.281
ENSG00000108604 E027 91.730103 6.959846e-03 8.570845e-05 1.314364e-03 17 63842459 63842465 7 - 1.678 1.939 0.881
ENSG00000108604 E028 261.648829 2.009315e-03 1.443455e-06 3.912719e-05 17 63842466 63842868 403 - 2.199 2.375 0.587
ENSG00000108604 E029 1.334785 1.452461e-02 8.737939e-01   17 63843020 63843272 253 - 0.341 0.311 -0.192
ENSG00000108604 E030 1.653310 1.520189e-02 7.385370e-01 8.595690e-01 17 63843273 63843433 161 - 0.341 0.408 0.385