ENSG00000108599

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000225737 ENSG00000108599 HEK293_OSMI2_6hA HEK293_TMG_6hB AKAP10 protein_coding protein_coding 7.19798 3.534177 12.16399 0.634736 0.7265754 1.780279 4.4435429 2.4788795 7.5197718 0.3044697 0.03974266 1.5971098 0.69125833 0.7190000 0.62276667 -0.09623333 7.213485e-01 1.359366e-05 FALSE TRUE
ENST00000395536 ENSG00000108599 HEK293_OSMI2_6hA HEK293_TMG_6hB AKAP10 protein_coding protein_coding 7.19798 3.534177 12.16399 0.634736 0.7265754 1.780279 0.2047474 0.0000000 1.0571573 0.0000000 0.11896164 6.7376290 0.01821667 0.0000000 0.08860000 0.08860000 1.359366e-05 1.359366e-05 FALSE TRUE
MSTRG.13872.3 ENSG00000108599 HEK293_OSMI2_6hA HEK293_TMG_6hB AKAP10 protein_coding   7.19798 3.534177 12.16399 0.634736 0.7265754 1.780279 1.0297142 0.0000000 1.0422658 0.0000000 0.52120363 6.7173554 0.09446667 0.0000000 0.08110000 0.08110000 4.549214e-01 1.359366e-05 TRUE TRUE
MSTRG.13872.4 ENSG00000108599 HEK293_OSMI2_6hA HEK293_TMG_6hB AKAP10 protein_coding   7.19798 3.534177 12.16399 0.634736 0.7265754 1.780279 0.7087612 0.6228858 0.8925811 0.1358874 0.13074178 0.5121114 0.09899167 0.1737667 0.07526667 -0.09850000 1.188308e-01 1.359366e-05 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000108599 E001 19.2128116 0.512413984 0.39391774 0.62345100 17 19904302 19904907 606 - 1.196 1.373 0.620
ENSG00000108599 E002 16.1021599 0.438872860 0.26264697 0.50185645 17 19904908 19905060 153 - 1.086 1.367 0.994
ENSG00000108599 E003 27.9436215 0.567450346 0.20498115 0.43588878 17 19905061 19905230 170 - 1.288 1.631 1.179
ENSG00000108599 E004 121.5257111 1.342276417 0.36033039 0.59596501 17 19905231 19905996 766 - 1.918 2.248 1.106
ENSG00000108599 E005 57.4486877 0.860388515 0.40608213 0.63312693 17 19905997 19906167 171 - 1.645 1.850 0.694
ENSG00000108599 E006 31.6653814 0.668163974 0.39939818 0.62776618 17 19906168 19906226 59 - 1.403 1.581 0.613
ENSG00000108599 E007 21.5799513 0.560772475 0.49022819 0.69416192 17 19906227 19906232 6 - 1.265 1.376 0.386
ENSG00000108599 E008 41.1043133 0.017293132 0.29426823 0.53485362 17 19909181 19909238 58 - 1.530 1.668 0.471
ENSG00000108599 E009 36.3502935 0.001966007 0.37798768 0.61052811 17 19909239 19909276 38 - 1.487 1.607 0.411
ENSG00000108599 E010 38.5731110 0.008408715 0.42218956 0.64528896 17 19909926 19909978 53 - 1.508 1.630 0.417
ENSG00000108599 E011 48.7709842 0.004856516 0.81644031 0.90612848 17 19920036 19920118 83 - 1.626 1.683 0.191
ENSG00000108599 E012 40.4653797 0.021045749 0.52125057 0.71574064 17 19924408 19924512 105 - 1.555 1.572 0.057
ENSG00000108599 E013 16.7440573 0.026626591 0.14517341 0.35515997 17 19924513 19924517 5 - 1.215 1.107 -0.385
ENSG00000108599 E014 37.7247395 0.030961655 0.49252707 0.69569146 17 19931805 19931978 174 - 1.528 1.530 0.008
ENSG00000108599 E015 1.1420522 0.014849547 0.06771513   17 19936002 19936285 284 - 0.360 0.000 -10.334
ENSG00000108599 E016 46.2178661 0.009793082 0.94086812 0.97268733 17 19936286 19936430 145 - 1.598 1.666 0.233
ENSG00000108599 E017 51.8345403 0.012725870 0.64384540 0.79943817 17 19939713 19939849 137 - 1.653 1.689 0.122
ENSG00000108599 E018 21.6912461 0.060157206 0.13872345 0.34557344 17 19940887 19940897 11 - 1.328 1.181 -0.517
ENSG00000108599 E019 44.9204005 0.016291056 0.14768605 0.35896960 17 19940898 19941010 113 - 1.612 1.558 -0.185
ENSG00000108599 E020 44.7221808 0.020815407 0.61315182 0.77906739 17 19941826 19941910 85 - 1.592 1.622 0.105
ENSG00000108599 E021 0.0000000       17 19947141 19947406 266 -      
ENSG00000108599 E022 47.7697198 0.010532526 0.30641888 0.54705538 17 19947407 19947505 99 - 1.629 1.629 -0.001
ENSG00000108599 E023 82.0087229 0.017680718 0.54187085 0.73040975 17 19958014 19958334 321 - 1.849 1.878 0.097
ENSG00000108599 E024 49.7335425 0.008411499 0.03379632 0.13832296 17 19958335 19958424 90 - 1.663 1.582 -0.277
ENSG00000108599 E025 33.8909830 0.024564351 0.13679648 0.34259839 17 19958425 19958443 19 - 1.500 1.427 -0.250
ENSG00000108599 E026 56.0125039 0.008516970 0.03696516 0.14683332 17 19958444 19958567 124 - 1.713 1.641 -0.246
ENSG00000108599 E027 22.8089801 0.002082599 0.43617165 0.65593379 17 19958568 19958571 4 - 1.317 1.317 -0.001
ENSG00000108599 E028 28.3148800 0.004399577 0.19465517 0.42288805 17 19962840 19962859 20 - 1.417 1.382 -0.122
ENSG00000108599 E029 42.0488881 0.008890961 0.02906014 0.12453827 17 19962860 19962966 107 - 1.598 1.503 -0.325
ENSG00000108599 E030 18.9175337 0.006523630 0.05428286 0.18975091 17 19962967 19962991 25 - 1.268 1.145 -0.438
ENSG00000108599 E031 17.7177831 0.005343579 0.15957287 0.37614713 17 19962992 19963022 31 - 1.232 1.162 -0.250
ENSG00000108599 E032 1.5110739 0.012198908 0.57882114 0.75639369 17 19967919 19968034 116 - 0.394 0.327 -0.391
ENSG00000108599 E033 21.5794807 0.027007013 0.09588722 0.27456365 17 19968414 19968461 48 - 1.325 1.218 -0.377
ENSG00000108599 E034 20.6182971 0.001844719 0.01663568 0.08410768 17 19977592 19977828 237 - 1.313 1.162 -0.533
ENSG00000108599 E035 0.1779838 0.054574509 1.00000000   17 19978234 19978343 110 - 0.074 0.000 -7.529