ENSG00000108582

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000225719 ENSG00000108582 HEK293_OSMI2_6hA HEK293_TMG_6hB CPD protein_coding protein_coding 12.33833 4.218767 21.94851 1.441898 0.9436126 2.376471 5.5725615 2.0703880 8.633798 0.5079963 2.0078912 2.0548126 0.48215000 0.53213333 0.38703333 -0.14510000 6.902080e-01 4.813813e-24 FALSE TRUE
ENST00000543464 ENSG00000108582 HEK293_OSMI2_6hA HEK293_TMG_6hB CPD protein_coding protein_coding 12.33833 4.218767 21.94851 1.441898 0.9436126 2.376471 2.8842100 0.0000000 6.907061 0.0000000 0.8262363 9.4340153 0.14193750 0.00000000 0.31880000 0.31880000 2.660632e-11 4.813813e-24 FALSE TRUE
ENST00000579502 ENSG00000108582 HEK293_OSMI2_6hA HEK293_TMG_6hB CPD protein_coding nonsense_mediated_decay 12.33833 4.218767 21.94851 1.441898 0.9436126 2.376471 0.6174897 0.8552714 0.000000 0.2530914 0.0000000 -6.4350809 0.14945000 0.21166667 0.00000000 -0.21166667 4.813813e-24 4.813813e-24   FALSE
ENST00000584051 ENSG00000108582 HEK293_OSMI2_6hA HEK293_TMG_6hB CPD protein_coding processed_transcript 12.33833 4.218767 21.94851 1.441898 0.9436126 2.376471 0.7000641 0.9246684 1.555223 0.9246684 0.3626885 0.7438417 0.05754167 0.13690000 0.07203333 -0.06486667 7.438187e-01 4.813813e-24 FALSE FALSE
MSTRG.14021.2 ENSG00000108582 HEK293_OSMI2_6hA HEK293_TMG_6hB CPD protein_coding   12.33833 4.218767 21.94851 1.441898 0.9436126 2.376471 2.2157457 0.2777346 4.605400 0.1702192 0.1368749 4.0036453 0.12145417 0.09383333 0.21110000 0.11726667 6.381300e-01 4.813813e-24 TRUE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000108582 E001 41.9519993 0.0552920616 0.4450279860 0.662145715 17 30378927 30379615 689 + 1.436 1.665 0.782
ENSG00000108582 E002 21.4119415 0.0169610852 0.2851281734 0.525721291 17 30379616 30379726 111 + 1.200 1.175 -0.090
ENSG00000108582 E003 0.0000000       17 30380236 30380642 407 +      
ENSG00000108582 E004 94.3500353 0.0330469160 0.0008882982 0.009000804 17 30384989 30385236 248 + 1.843 1.600 -0.824
ENSG00000108582 E005 0.2852693 0.1896053076 1.0000000000   17 30385237 30385292 56 + 0.096 0.000 -9.093
ENSG00000108582 E006 90.5678541 0.0277220258 0.0062681491 0.041037661 17 30420841 30420983 143 + 1.818 1.659 -0.537
ENSG00000108582 E007 85.7646326 0.0168018430 0.0968985510 0.276295420 17 30421664 30421833 170 + 1.780 1.758 -0.076
ENSG00000108582 E008 138.1853418 0.0131570750 0.0065784217 0.042599614 17 30422674 30423023 350 + 1.991 1.913 -0.262
ENSG00000108582 E009 110.4216783 0.0272433801 0.0359706165 0.144146444 17 30423506 30423697 192 + 1.895 1.814 -0.273
ENSG00000108582 E010 99.7400966 0.0252239790 0.0828378653 0.250405390 17 30427391 30427558 168 + 1.847 1.794 -0.181
ENSG00000108582 E011 74.8328182 0.0291969329 0.2398483501 0.476459096 17 30431772 30431881 110 + 1.719 1.707 -0.041
ENSG00000108582 E012 37.3660187 0.0228599822 0.0571734826 0.196402871 17 30438975 30438984 10 + 1.434 1.338 -0.335
ENSG00000108582 E013 70.7898295 0.0145552039 0.0086547819 0.052279865 17 30438985 30439077 93 + 1.708 1.591 -0.398
ENSG00000108582 E014 101.1417647 0.0221746908 0.0189230798 0.092179857 17 30442308 30442450 143 + 1.859 1.758 -0.341
ENSG00000108582 E015 96.7463547 0.0270848507 0.1357194866 0.340905654 17 30443802 30443971 170 + 1.829 1.803 -0.090
ENSG00000108582 E016 0.1614157 0.0337876356 1.0000000000   17 30443972 30444144 173 + 0.051 0.000 -8.111
ENSG00000108582 E017 136.2235525 0.0171055650 0.0996691129 0.281159910 17 30445691 30446020 330 + 1.975 1.959 -0.053
ENSG00000108582 E018 0.0000000       17 30447562 30447564 3 +      
ENSG00000108582 E019 95.8471543 0.0153917756 0.4913863875 0.694884757 17 30449553 30449672 120 + 1.813 1.870 0.190
ENSG00000108582 E020 72.8613727 0.0306449327 0.4181334798 0.642248302 17 30449673 30449748 76 + 1.701 1.729 0.093
ENSG00000108582 E021 1.2021518 0.0432694157 0.9346104958   17 30450236 30450294 59 + 0.245 0.262 0.130
ENSG00000108582 E022 69.7379450 0.0216590655 0.8258987333 0.911443689 17 30451711 30451756 46 + 1.674 1.758 0.284
ENSG00000108582 E023 79.3230076 0.0148883986 0.6603805982 0.810185112 17 30451757 30451809 53 + 1.731 1.804 0.245
ENSG00000108582 E024 69.4102429 0.0214465068 0.5926642939 0.765378426 17 30451810 30451846 37 + 1.677 1.732 0.187
ENSG00000108582 E025 0.8346052 0.2069803486 0.7782715901   17 30454021 30455338 1318 + 0.178 0.263 0.710
ENSG00000108582 E026 103.3869558 0.0258785765 0.8251867104 0.911030891 17 30455339 30455470 132 + 1.834 1.963 0.435
ENSG00000108582 E027 0.0000000       17 30455471 30456255 785 +      
ENSG00000108582 E028 74.9232003 0.0351123378 0.7304104220 0.854467538 17 30456256 30456324 69 + 1.702 1.792 0.303
ENSG00000108582 E029 61.0647295 0.0343728184 0.7365761040 0.858323966 17 30456325 30456351 27 + 1.614 1.713 0.335
ENSG00000108582 E030 70.2975940 0.0197758026 0.8541924024 0.927189101 17 30456462 30456526 65 + 1.667 1.809 0.478
ENSG00000108582 E031 0.4654660 0.0231114359 1.0000000000   17 30456527 30456863 337 + 0.139 0.000 -9.695
ENSG00000108582 E032 82.8466118 0.0068020732 0.1735452200 0.395257361 17 30461180 30461311 132 + 1.758 1.777 0.063
ENSG00000108582 E033 40.5183352 0.0009459145 0.2016729448 0.431724499 17 30461877 30461885 9 + 1.461 1.464 0.010
ENSG00000108582 E034 99.7378480 0.0060232993 0.0832959502 0.251360583 17 30461886 30462062 177 + 1.844 1.837 -0.023
ENSG00000108582 E035 42.2957551 0.0138849895 0.1403022252 0.347966964 17 30462370 30462395 26 + 1.485 1.438 -0.163
ENSG00000108582 E036 63.1110427 0.0166583773 0.8519864888 0.926204066 17 30462396 30462469 74 + 1.633 1.733 0.340
ENSG00000108582 E037 406.0529694 1.1437567538 0.3959984245 0.625188398 17 30464588 30466246 1659 + 2.391 2.686 0.980
ENSG00000108582 E038 413.6133889 0.8161524072 0.2468086145 0.484477365 17 30466247 30469989 3743 + 2.379 2.754 1.249