ENSG00000108578

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000261714 ENSG00000108578 HEK293_OSMI2_6hA HEK293_TMG_6hB BLMH protein_coding protein_coding 40.40866 31.11115 42.43148 5.380552 2.450712 0.4475796 37.48731 28.99192 36.41357 4.917 2.472099 0.3287241 0.9271958 0.9333 0.8572 -0.0761 0.006784209 0.006784209 FALSE  
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000108578 E001 3.1721204 0.2348772298 0.5776732241 0.755578886 17 30248203 30248204 2 - 0.575 0.670 0.414
ENSG00000108578 E002 492.3131571 1.6546420839 0.4863048484 0.691471970 17 30248205 30248821 617 - 2.565 2.799 0.776
ENSG00000108578 E003 447.6999120 1.6380057128 0.5201598152 0.715068567 17 30248822 30249168 347 - 2.545 2.743 0.659
ENSG00000108578 E004 3.0478146 0.0332568426 0.0010827501 0.010548179 17 30249169 30250283 1115 - 0.207 0.812 3.164
ENSG00000108578 E005 0.2735028 0.0259533658 0.9952610735   17 30266879 30266884 6 - 0.116 0.127 0.149
ENSG00000108578 E006 251.4501132 0.0144521455 0.2908887234 0.531504209 17 30266885 30266954 70 - 2.351 2.452 0.337
ENSG00000108578 E007 0.3641499 0.0278458362 1.0000000000   17 30271269 30271270 2 - 0.116 0.127 0.153
ENSG00000108578 E008 318.9852052 0.0002091606 0.6341694496 0.793052713 17 30271271 30271388 118 - 2.474 2.534 0.201
ENSG00000108578 E009 3.6785816 0.0075214794 0.0133844318 0.071966323 17 30271389 30271493 105 - 0.813 0.482 -1.437
ENSG00000108578 E010 3.8553775 0.0079581303 0.1063425187 0.292894405 17 30272258 30272560 303 - 0.771 0.571 -0.847
ENSG00000108578 E011 234.1830635 0.0122725755 0.8089319363 0.901552738 17 30272561 30272628 68 - 2.333 2.408 0.251
ENSG00000108578 E012 302.5354634 0.0141385104 0.6076354402 0.775308600 17 30272741 30272889 149 - 2.463 2.501 0.125
ENSG00000108578 E013 126.5209251 0.0076367491 0.5175361807 0.713331278 17 30272890 30272899 10 - 2.090 2.119 0.098
ENSG00000108578 E014 5.3674966 0.0056183953 0.0162606380 0.082754363 17 30272900 30273130 231 - 0.922 0.643 -1.114
ENSG00000108578 E015 4.0871653 0.1484680381 0.5790154729 0.756530106 17 30273278 30273479 202 - 0.753 0.643 -0.459
ENSG00000108578 E016 4.8147462 0.0230416403 0.1278881708 0.328493577 17 30273765 30274037 273 - 0.833 0.646 -0.759
ENSG00000108578 E017 1.8210936 0.0237617850 0.0890270970 0.261942526 17 30274038 30274041 4 - 0.574 0.305 -1.431
ENSG00000108578 E018 228.5829195 0.0113475912 0.2980379859 0.538495227 17 30274042 30274197 156 - 2.355 2.366 0.039
ENSG00000108578 E019 218.8222552 0.0067284968 0.0387030388 0.151359491 17 30285388 30285480 93 - 2.355 2.325 -0.098
ENSG00000108578 E020 5.2241261 0.0652429482 0.0079454772 0.049068140 17 30285481 30285539 59 - 0.954 0.525 -1.765
ENSG00000108578 E021 169.0049175 0.0133665268 0.0158023653 0.081092832 17 30286814 30286851 38 - 2.269 2.183 -0.286
ENSG00000108578 E022 160.3316553 0.0086767593 0.0076029239 0.047494991 17 30286852 30286902 51 - 2.243 2.164 -0.266
ENSG00000108578 E023 116.8594814 0.0067185166 0.0228727688 0.105538690 17 30287806 30287823 18 - 2.096 2.040 -0.188
ENSG00000108578 E024 218.8113851 0.0089767877 0.0278072509 0.120731983 17 30287824 30287947 124 - 2.363 2.315 -0.160
ENSG00000108578 E025 108.0243844 0.0020235216 0.0002577641 0.003301964 17 30289373 30289413 41 - 2.081 1.990 -0.306
ENSG00000108578 E026 146.0038287 0.0028186939 0.0001924606 0.002591930 17 30289414 30289482 69 - 2.209 2.122 -0.290
ENSG00000108578 E027 0.9994175 0.0503560252 0.0090699443   17 30290990 30291179 190 - 0.454 0.000 -11.343
ENSG00000108578 E028 1.6053550 0.6551892031 0.4097618247 0.635828535 17 30291180 30291310 131 - 0.513 0.288 -1.265
ENSG00000108578 E029 190.1457270 0.0132497077 0.4777040470 0.685572241 17 30291311 30291491 181 - 2.272 2.291 0.061
ENSG00000108578 E030 79.8727218 0.0155504872 0.9073073330 0.955761351 17 30291492 30291508 17 - 1.881 1.933 0.176
ENSG00000108578 E031 0.7201878 0.0273182577 0.1740177788   17 30291589 30291806 218 - 0.347 0.127 -1.848
ENSG00000108578 E032 107.0139128 0.0210590969 0.6152438502 0.780436941 17 30291807 30291913 107 - 1.981 2.082 0.341
ENSG00000108578 E033 60.4488464 0.0346468110 0.1672473485 0.386896330 17 30291914 30292056 143 - 1.680 1.880 0.677