ENSG00000108557

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000353383 ENSG00000108557 HEK293_OSMI2_6hA HEK293_TMG_6hB RAI1 protein_coding protein_coding 11.46404 17.20846 6.992569 1.021683 0.1485623 -1.298 6.0854569 9.794163 3.4911750 1.0452619 0.08624865 -1.4855553 0.53193750 0.5668000 0.4992333 -0.06756667 7.121596e-01 6.650374e-23 FALSE TRUE
ENST00000395774 ENSG00000108557 HEK293_OSMI2_6hA HEK293_TMG_6hB RAI1 protein_coding protein_coding 11.46404 17.20846 6.992569 1.021683 0.1485623 -1.298 0.6455922 0.000000 1.3579504 0.0000000 0.10795113 7.0958721 0.07808333 0.0000000 0.1938667 0.19386667 6.650374e-23 6.650374e-23 FALSE TRUE
ENST00000582514 ENSG00000108557 HEK293_OSMI2_6hA HEK293_TMG_6hB RAI1 protein_coding processed_transcript 11.46404 17.20846 6.992569 1.021683 0.1485623 -1.298 2.6707970 4.183053 0.5527907 0.1433886 0.30436874 -2.8973307 0.20375417 0.2437667 0.0809000 -0.16286667 5.212307e-01 6.650374e-23   FALSE
ENST00000583166 ENSG00000108557 HEK293_OSMI2_6hA HEK293_TMG_6hB RAI1 protein_coding protein_coding 11.46404 17.20846 6.992569 1.021683 0.1485623 -1.298 1.3656767 2.358041 1.2042254 0.4755666 0.27257530 -0.9636578 0.12378333 0.1390333 0.1707333 0.03170000 8.906489e-01 6.650374e-23 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000108557 E001 2.9603807 0.0360448089 0.7219912685 0.849275292 17 17681431 17681457 27 + 0.514 0.572 0.270
ENSG00000108557 E002 9.9182779 0.0035187662 0.1056718842 0.291818293 17 17681458 17681728 271 + 0.824 1.015 0.723
ENSG00000108557 E003 9.7990693 0.0439552709 0.8279205135 0.912571853 17 17681729 17681793 65 + 1.003 0.960 -0.159
ENSG00000108557 E004 0.0000000       17 17682495 17682563 69 +      
ENSG00000108557 E005 4.4446612 0.0068487707 0.0349351719 0.141410639 17 17683546 17683703 158 + 0.892 0.575 -1.303
ENSG00000108557 E006 13.0762251 0.0207387771 0.0165023445 0.083648804 17 17683704 17685050 1347 + 1.282 0.987 -1.059
ENSG00000108557 E007 25.7856647 0.0088853820 0.3796867709 0.611940823 17 17724028 17724159 132 + 1.433 1.340 -0.321
ENSG00000108557 E008 0.7389688 0.0193698730 0.0113148094   17 17782132 17782215 84 + 0.514 0.073 -3.626
ENSG00000108557 E009 1135.4405786 0.0072190867 0.0003138477 0.003870348 17 17792933 17798383 5451 + 3.048 2.967 -0.272
ENSG00000108557 E010 73.1656921 0.0029441216 0.1683570213 0.388352432 17 17798384 17798513 130 + 1.761 1.817 0.189
ENSG00000108557 E011 69.0951132 0.0005882514 0.7244154186 0.850790273 17 17803756 17803849 94 + 1.806 1.772 -0.113
ENSG00000108557 E012 16.5915252 0.0524014950 0.6403106999 0.797088413 17 17803850 17804114 265 + 1.239 1.164 -0.267
ENSG00000108557 E013 5.4875618 0.2540620705 0.5197454019 0.714856189 17 17809282 17809389 108 + 0.647 0.785 0.568
ENSG00000108557 E014 47.8437420 0.0008058066 0.3007687152 0.541237261 17 17809390 17809439 50 + 1.591 1.636 0.152
ENSG00000108557 E015 255.9714133 0.0081034577 0.0004027827 0.004757722 17 17809970 17810733 764 + 2.229 2.373 0.482
ENSG00000108557 E016 160.1513745 0.0773653413 0.0473422350 0.173372445 17 17810734 17811453 720 + 1.970 2.182 0.713