ENSG00000108424

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000290158 ENSG00000108424 HEK293_OSMI2_6hA HEK293_TMG_6hB KPNB1 protein_coding protein_coding 281.1559 175.6276 392.0564 40.52672 7.898516 1.158497 24.92184 18.507864 23.697545 4.983051 1.2153239 0.3564286 0.10339583 0.10470000 0.060400000 -0.04430000 0.0122671144 0.0005163763 FALSE TRUE
ENST00000577875 ENSG00000108424 HEK293_OSMI2_6hA HEK293_TMG_6hB KPNB1 protein_coding protein_coding 281.1559 175.6276 392.0564 40.52672 7.898516 1.158497 21.18567 5.854748 35.006620 1.306584 5.8817568 2.5778988 0.06872083 0.03500000 0.089066667 0.05406667 0.0385614423 0.0005163763 FALSE FALSE
ENST00000577918 ENSG00000108424 HEK293_OSMI2_6hA HEK293_TMG_6hB KPNB1 protein_coding processed_transcript 281.1559 175.6276 392.0564 40.52672 7.898516 1.158497 46.10622 27.247018 72.322899 5.639599 6.0080306 1.4080243 0.14178333 0.15803333 0.184500000 0.02646667 0.7816280179 0.0005163763 FALSE TRUE
ENST00000579901 ENSG00000108424 HEK293_OSMI2_6hA HEK293_TMG_6hB KPNB1 protein_coding processed_transcript 281.1559 175.6276 392.0564 40.52672 7.898516 1.158497 20.48981 4.575892 40.680255 2.429436 8.1008042 3.1494091 0.05695000 0.02106667 0.104633333 0.08356667 0.5318894309 0.0005163763 FALSE FALSE
ENST00000677341 ENSG00000108424 HEK293_OSMI2_6hA HEK293_TMG_6hB KPNB1 protein_coding retained_intron 281.1559 175.6276 392.0564 40.52672 7.898516 1.158497 13.34480 13.767249 1.626918 6.838402 0.1872808 -3.0732340 0.07470000 0.06663333 0.004166667 -0.06246667 0.0007656696 0.0005163763 FALSE TRUE
MSTRG.14561.14 ENSG00000108424 HEK293_OSMI2_6hA HEK293_TMG_6hB KPNB1 protein_coding   281.1559 175.6276 392.0564 40.52672 7.898516 1.158497 72.94342 50.571563 99.131494 11.436855 3.9599400 0.9708774 0.25769167 0.28846667 0.252633333 -0.03583333 0.4728766735 0.0005163763 FALSE TRUE
MSTRG.14561.5 ENSG00000108424 HEK293_OSMI2_6hA HEK293_TMG_6hB KPNB1 protein_coding   281.1559 175.6276 392.0564 40.52672 7.898516 1.158497 30.83730 25.581912 46.332942 6.845320 3.3128787 0.8566617 0.11498333 0.14210000 0.117933333 -0.02416667 0.7009537959 0.0005163763 FALSE TRUE
MSTRG.14561.6 ENSG00000108424 HEK293_OSMI2_6hA HEK293_TMG_6hB KPNB1 protein_coding   281.1559 175.6276 392.0564 40.52672 7.898516 1.158497 33.43762 21.530999 44.201969 3.876906 2.3647316 1.0373518 0.11990417 0.12720000 0.112766667 -0.01443333 0.8411847270 0.0005163763 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000108424 E001 0.9122530 0.2537232949 5.249775e-01   17 47649476 47649494 19 + 0.181 0.354 1.280
ENSG00000108424 E002 26.6032089 0.0015568903 3.990140e-01 6.273946e-01 17 47649495 47649877 383 + 1.406 1.479 0.253
ENSG00000108424 E003 23.8640382 0.0024155736 8.518935e-01 9.261263e-01 17 47649919 47649924 6 + 1.379 1.410 0.109
ENSG00000108424 E004 58.0868048 0.0055588852 9.675093e-01 9.856881e-01 17 47649925 47649937 13 + 1.759 1.774 0.052
ENSG00000108424 E005 66.3623215 0.0052940561 6.483007e-01 8.023842e-01 17 47649938 47649942 5 + 1.826 1.818 -0.027
ENSG00000108424 E006 165.6822394 0.0063806495 6.368400e-02 2.110163e-01 17 47649943 47650003 61 + 2.244 2.166 -0.261
ENSG00000108424 E007 179.9298895 0.0032258756 2.479762e-02 1.115982e-01 17 47650004 47650102 99 + 2.277 2.204 -0.245
ENSG00000108424 E008 69.3137954 0.0007448585 3.341866e-02 1.372360e-01 17 47650103 47650151 49 + 1.872 1.793 -0.265
ENSG00000108424 E009 72.5212490 0.0073847889 5.375706e-01 7.273574e-01 17 47650152 47650177 26 + 1.831 1.889 0.197
ENSG00000108424 E010 160.2752507 0.0043643998 9.950278e-01 9.990694e-01 17 47650178 47650215 38 + 2.190 2.212 0.074
ENSG00000108424 E011 321.0068405 0.0064741877 9.253088e-02 2.684709e-01 17 47650216 47650284 69 + 2.522 2.462 -0.202
ENSG00000108424 E012 1.8081594 0.0521610612 5.974002e-01 7.685954e-01 17 47650358 47650385 28 + 0.489 0.411 -0.404
ENSG00000108424 E013 461.5508757 0.0018722851 6.006576e-03 3.975427e-02 17 47650386 47650444 59 + 2.678 2.620 -0.194
ENSG00000108424 E014 13.3504598 0.0069980064 8.443311e-02 2.535801e-01 17 47651196 47651376 181 + 1.214 1.055 -0.568
ENSG00000108424 E015 1188.8748388 0.0014704954 3.910224e-07 1.247324e-05 17 47652694 47652876 183 + 3.100 3.009 -0.303
ENSG00000108424 E016 961.9045319 0.0019777492 6.545032e-06 1.455411e-04 17 47656860 47656924 65 + 3.009 2.916 -0.311
ENSG00000108424 E017 1486.6420782 0.0020207514 1.237232e-06 3.416431e-05 17 47656925 47657060 136 + 3.200 3.102 -0.323
ENSG00000108424 E018 1566.3344779 0.0012660127 7.099370e-09 3.442708e-07 17 47658508 47658660 153 + 3.221 3.127 -0.314
ENSG00000108424 E019 1.8840871 0.2009040572 5.456542e-01 7.331933e-01 17 47660882 47660904 23 + 0.494 0.347 -0.789
ENSG00000108424 E020 1.9969821 0.0685685942 1.158796e-01 3.089408e-01 17 47660905 47660935 31 + 0.558 0.256 -1.699
ENSG00000108424 E021 6.8216385 0.1272977986 4.656926e-01 6.770721e-01 17 47660936 47661118 183 + 0.933 0.796 -0.527
ENSG00000108424 E022 996.6608879 0.0011063994 1.866018e-06 4.905461e-05 17 47661119 47661178 60 + 3.017 2.942 -0.249
ENSG00000108424 E023 3.2692822 0.1717445277 1.888799e-01 4.155581e-01 17 47662169 47662238 70 + 0.718 0.415 -1.399
ENSG00000108424 E024 2.2648028 0.7679323710 7.301633e-01 8.543484e-01 17 47662550 47662650 101 + 0.482 0.544 0.296
ENSG00000108424 E025 1064.2563287 0.0014439027 1.260269e-06 3.471546e-05 17 47663089 47663178 90 + 3.050 2.965 -0.284
ENSG00000108424 E026 1194.7458804 0.0013421716 1.940462e-04 2.610179e-03 17 47664159 47664269 111 + 3.090 3.034 -0.187
ENSG00000108424 E027 548.7778826 0.0019063226 2.465792e-01 4.842644e-01 17 47665057 47665060 4 + 2.735 2.723 -0.040
ENSG00000108424 E028 1136.6320898 0.0009387034 1.181598e-01 3.128215e-01 17 47665061 47665158 98 + 3.050 3.042 -0.027
ENSG00000108424 E029 1456.8338216 0.0009870218 1.891141e-01 4.158478e-01 17 47668186 47668364 179 + 3.157 3.152 -0.016
ENSG00000108424 E030 798.0594353 0.0012098870 5.960563e-01 7.677739e-01 17 47668365 47668410 46 + 2.891 2.900 0.029
ENSG00000108424 E031 7.3534001 0.0089824393 2.135813e-03 1.798374e-02 17 47668411 47668801 391 + 1.027 0.624 -1.589
ENSG00000108424 E032 6.3070734 0.0107035922 3.247212e-01 5.639830e-01 17 47669573 47669677 105 + 0.792 0.935 0.547
ENSG00000108424 E033 1381.4456667 0.0002292348 4.552525e-01 6.697073e-01 17 47669678 47669869 192 + 3.128 3.138 0.033
ENSG00000108424 E034 0.7962354 0.0567653588 3.886862e-01   17 47670324 47670343 20 + 0.182 0.342 1.201
ENSG00000108424 E035 1.3139786 0.1071449511 2.391790e-01   17 47670377 47670457 81 + 0.250 0.479 1.371
ENSG00000108424 E036 1183.4825112 0.0021933768 3.432509e-01 5.809237e-01 17 47670702 47670832 131 + 3.062 3.066 0.013
ENSG00000108424 E037 0.5365243 0.0248156081 3.631463e-01   17 47671710 47671862 153 + 0.101 0.256 1.618
ENSG00000108424 E038 1155.4434707 0.0020614408 2.795881e-02 1.211639e-01 17 47673018 47673088 71 + 3.064 3.037 -0.088
ENSG00000108424 E039 1267.9744336 0.0035707312 1.278519e-01 3.284501e-01 17 47673089 47673165 77 + 3.102 3.082 -0.067
ENSG00000108424 E040 1385.0506736 0.0041497719 1.562895e-01 3.713091e-01 17 47673490 47673561 72 + 3.141 3.120 -0.070
ENSG00000108424 E041 2.2047056 0.2158682519 3.930582e-01 6.228460e-01 17 47673562 47673839 278 + 0.562 0.348 -1.109
ENSG00000108424 E042 1728.2592736 0.0026080929 5.037981e-01 7.034390e-01 17 47674638 47674782 145 + 3.226 3.232 0.020
ENSG00000108424 E043 16.6612741 0.2576191962 9.406823e-01 9.726114e-01 17 47675714 47676076 363 + 1.222 1.260 0.135
ENSG00000108424 E044 15.4512062 0.1115671949 7.917545e-01 8.914724e-01 17 47676077 47676408 332 + 1.179 1.245 0.235
ENSG00000108424 E045 1243.1017425 0.0019575088 8.403618e-01 9.196240e-01 17 47676409 47676491 83 + 3.078 3.096 0.060
ENSG00000108424 E046 1214.5904253 0.0007515867 8.106262e-01 9.026311e-01 17 47677020 47677127 108 + 3.065 3.090 0.082
ENSG00000108424 E047 1456.8492330 0.0007932155 9.982782e-01 1.000000e+00 17 47678046 47678189 144 + 3.145 3.166 0.069
ENSG00000108424 E048 1424.3452727 0.0001143120 9.244680e-02 2.682909e-01 17 47678308 47678413 106 + 3.130 3.166 0.118
ENSG00000108424 E049 112.6588635 0.1161973582 9.072321e-01 9.557467e-01 17 47678414 47680019 1606 + 2.023 2.081 0.194
ENSG00000108424 E050 1645.9167836 0.0002306019 4.059739e-02 1.563134e-01 17 47680020 47680134 115 + 3.191 3.232 0.136
ENSG00000108424 E051 1721.0938125 0.0109092712 2.339467e-01 4.696949e-01 17 47680508 47680602 95 + 3.196 3.270 0.246
ENSG00000108424 E052 1379.5303781 0.0646670997 2.468667e-01 4.845469e-01 17 47680603 47680669 67 + 3.077 3.202 0.418
ENSG00000108424 E053 2344.3492353 0.1409257605 1.339969e-01 3.380836e-01 17 47682404 47682790 387 + 3.261 3.478 0.723
ENSG00000108424 E054 4033.8349629 0.0007289586 7.587928e-15 1.134335e-12 17 47682791 47684312 1522 + 3.541 3.668 0.423
ENSG00000108424 E055 588.1541444 0.0046636408 8.442298e-06 1.811595e-04 17 47684313 47685505 1193 + 2.674 2.862 0.624