ENSG00000108306

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000264658 ENSG00000108306 HEK293_OSMI2_6hA HEK293_TMG_6hB FBXL20 protein_coding protein_coding 4.465124 2.782663 6.965635 0.4948741 0.4644336 1.320683 1.406924 1.4702332 1.430818 0.1761070 0.1566231 -0.03893595 0.3612042 0.5477000 0.2046667 -0.34303333 0.001530091 0.001530091 FALSE TRUE
ENST00000394294 ENSG00000108306 HEK293_OSMI2_6hA HEK293_TMG_6hB FBXL20 protein_coding protein_coding 4.465124 2.782663 6.965635 0.4948741 0.4644336 1.320683 1.412146 0.5665200 2.662145 0.2321522 0.4206691 2.21255576 0.2959583 0.2080000 0.3810667 0.17306667 0.554005137 0.001530091 FALSE TRUE
ENST00000577399 ENSG00000108306 HEK293_OSMI2_6hA HEK293_TMG_6hB FBXL20 protein_coding protein_coding 4.465124 2.782663 6.965635 0.4948741 0.4644336 1.320683 1.258288 0.6108494 1.803515 0.3317892 0.3987138 1.54647303 0.2696125 0.1868667 0.2671333 0.08026667 0.859942539 0.001530091 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000108306 E001 81.6917818 0.547430103 2.062762e-02 9.810944e-02 17 39252663 39254168 1506 - 1.484 2.199 2.414
ENSG00000108306 E002 175.5413612 0.006759507 1.852022e-05 3.578517e-04 17 39254169 39259130 4962 - 2.111 2.376 0.887
ENSG00000108306 E003 6.8749927 0.008990849 1.195887e-01 3.151747e-01 17 39259131 39259296 166 - 0.770 1.029 0.985
ENSG00000108306 E004 25.0819434 0.090038826 4.399664e-01 6.586774e-01 17 39259297 39260343 1047 - 1.406 1.413 0.024
ENSG00000108306 E005 7.5705750 0.246342281 7.381485e-01 8.593652e-01 17 39260344 39260579 236 - 0.952 0.883 -0.259
ENSG00000108306 E006 2.2817580 0.110510204 5.788601e-02 1.980492e-01 17 39260580 39260586 7 - 0.632 0.257 -2.023
ENSG00000108306 E007 35.3286833 0.625702005 5.432390e-01 7.313913e-01 17 39260587 39260986 400 - 1.516 1.600 0.287
ENSG00000108306 E008 32.7475595 0.608146137 6.065620e-01 7.745849e-01 17 39260987 39261260 274 - 1.500 1.547 0.159
ENSG00000108306 E009 33.0879315 0.598218311 5.852161e-01 7.604438e-01 17 39261261 39261451 191 - 1.501 1.555 0.185
ENSG00000108306 E010 13.2824135 0.263314619 6.379682e-01 7.957107e-01 17 39261452 39261459 8 - 1.117 1.189 0.257
ENSG00000108306 E011 26.2358387 0.307641968 5.601853e-01 7.434673e-01 17 39261460 39261567 108 - 1.391 1.476 0.293
ENSG00000108306 E012 0.3393995 0.026089942 2.834191e-01   17 39263876 39264174 299 - 0.181 0.000 -9.082
ENSG00000108306 E013 43.2982224 0.001033137 1.699908e-01 3.904273e-01 17 39264175 39264387 213 - 1.638 1.638 0.000
ENSG00000108306 E014 27.5561016 0.002004704 9.195840e-01 9.620012e-01 17 39265397 39265453 57 - 1.410 1.491 0.278
ENSG00000108306 E015 22.5170318 0.001702540 3.157924e-01 5.557966e-01 17 39268827 39268871 45 - 1.360 1.359 -0.003
ENSG00000108306 E016 31.0379492 0.007344860 3.536976e-02 1.425391e-01 17 39270796 39270856 61 - 1.518 1.445 -0.250
ENSG00000108306 E017 40.2564022 0.029407327 9.668125e-02 2.759353e-01 17 39274970 39275100 131 - 1.624 1.561 -0.214
ENSG00000108306 E018 32.2945547 0.047217249 4.617364e-02 1.704418e-01 17 39281389 39281463 75 - 1.562 1.412 -0.518
ENSG00000108306 E019 35.3394902 0.007648813 5.538448e-02 1.922012e-01 17 39282729 39282855 127 - 1.566 1.515 -0.177
ENSG00000108306 E020 28.1772649 0.051962273 2.284911e-02 1.054782e-01 17 39285478 39285573 96 - 1.512 1.343 -0.583
ENSG00000108306 E021 31.0595355 0.002468620 1.029777e-07 3.807531e-06 17 39297127 39297195 69 - 1.586 1.293 -1.013
ENSG00000108306 E022 36.2679271 0.019197153 3.017139e-04 3.747382e-03 17 39298990 39299084 95 - 1.632 1.410 -0.760
ENSG00000108306 E023 23.2574782 0.012672476 1.789308e-03 1.562612e-02 17 39301001 39301075 75 - 1.438 1.239 -0.693
ENSG00000108306 E024 20.3268873 0.069802534 3.387592e-02 1.385175e-01 17 39303585 39303639 55 - 1.392 1.164 -0.803
ENSG00000108306 E025 16.8590817 0.067580179 2.524659e-01 4.905619e-01 17 39343180 39343241 62 - 1.266 1.189 -0.270
ENSG00000108306 E026 7.7821680 0.047795618 6.464686e-01 8.011649e-01 17 39401361 39401656 296 - 0.917 0.943 0.097
ENSG00000108306 E027 0.0000000       17 39401666 39401706 41 -      
ENSG00000108306 E028 10.3190489 0.127586327 3.247074e-01 5.639763e-01 17 39402173 39402523 351 - 1.053 1.005 -0.174