ENSG00000108175

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000334512 ENSG00000108175 HEK293_OSMI2_6hA HEK293_TMG_6hB ZMIZ1 protein_coding protein_coding 8.315518 12.56751 6.933554 1.602443 0.1044321 -0.8571005 1.3497511 1.8699410 1.1514750 0.4613234 0.2912244 -0.6947293 0.16720417 0.14546667 0.1670667 0.021600000 0.97164636 0.02597004 FALSE TRUE
ENST00000472035 ENSG00000108175 HEK293_OSMI2_6hA HEK293_TMG_6hB ZMIZ1 protein_coding processed_transcript 8.315518 12.56751 6.933554 1.602443 0.1044321 -0.8571005 0.5120660 0.7108213 0.3328709 0.1681057 0.2126598 -1.0719763 0.06197500 0.05546667 0.0474000 -0.008066667 0.86796994 0.02597004 FALSE FALSE
MSTRG.4248.3 ENSG00000108175 HEK293_OSMI2_6hA HEK293_TMG_6hB ZMIZ1 protein_coding   8.315518 12.56751 6.933554 1.602443 0.1044321 -0.8571005 0.3028152 0.0000000 0.6900210 0.0000000 0.6900210 6.1293262 0.04232083 0.00000000 0.0976000 0.097600000 0.82118193 0.02597004 FALSE TRUE
MSTRG.4248.4 ENSG00000108175 HEK293_OSMI2_6hA HEK293_TMG_6hB ZMIZ1 protein_coding   8.315518 12.56751 6.933554 1.602443 0.1044321 -0.8571005 0.9275411 1.1448913 1.4481377 0.5966200 0.4669900 0.3363698 0.11317083 0.09963333 0.2109000 0.111266667 0.79206685 0.02597004 FALSE TRUE
MSTRG.4248.6 ENSG00000108175 HEK293_OSMI2_6hA HEK293_TMG_6hB ZMIZ1 protein_coding   8.315518 12.56751 6.933554 1.602443 0.1044321 -0.8571005 4.8296540 7.9797548 3.2047294 0.9046380 0.2242200 -1.3134539 0.56961250 0.63766667 0.4614667 -0.176200000 0.02597004 0.02597004 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000108175 E001 1.5560104 0.0866906475 3.398158e-01 5.778045e-01 10 79068966 79069072 107 + 0.500 0.341 -0.862
ENSG00000108175 E002 1.7871992 0.1139566663 9.241128e-01 9.644456e-01 10 79069073 79069124 52 + 0.436 0.458 0.111
ENSG00000108175 E003 2.7801840 0.0118153818 1.285442e-01 3.295700e-01 10 79069125 79069233 109 + 0.362 0.662 1.467
ENSG00000108175 E004 3.9990238 0.0504038526 6.581089e-01 8.087622e-01 10 79069234 79069270 37 + 0.607 0.738 0.555
ENSG00000108175 E005 12.2293703 0.0032792869 4.178850e-01 6.420622e-01 10 79118915 79119024 110 + 1.132 1.097 -0.126
ENSG00000108175 E006 19.9065247 0.0258387474 8.427617e-02 2.533013e-01 10 79139682 79139777 96 + 1.395 1.247 -0.514
ENSG00000108175 E007 12.7366705 0.0044365417 9.261065e-03 5.495447e-02 10 79162053 79162055 3 + 1.242 1.035 -0.742
ENSG00000108175 E008 19.6043906 0.0382226760 1.764209e-01 3.990051e-01 10 79162056 79162133 78 + 1.373 1.254 -0.419
ENSG00000108175 E009 23.1978147 0.0115107512 6.448564e-04 6.960178e-03 10 79201584 79201692 109 + 1.514 1.269 -0.848
ENSG00000108175 E010 23.3009221 0.0016181665 5.190613e-07 1.599792e-05 10 79208336 79208449 114 + 1.542 1.227 -1.093
ENSG00000108175 E011 22.3409517 0.0111686874 4.077862e-04 4.806127e-03 10 79216169 79216274 106 + 1.496 1.230 -0.923
ENSG00000108175 E012 0.1779838 0.0349795955 2.449460e-01   10 79242821 79242848 28 + 0.157 0.000 -12.234
ENSG00000108175 E013 2.2916280 0.0125232518 3.437113e-01 5.813754e-01 10 79242849 79242969 121 + 0.362 0.561 1.022
ENSG00000108175 E014 3.9844243 0.1485010991 3.305627e-01 5.695098e-01 10 79243669 79243738 70 + 0.505 0.765 1.133
ENSG00000108175 E015 0.4054685 0.5693138462 6.115106e-01   10 79277179 79277180 2 + 0.000 0.180 10.636
ENSG00000108175 E016 42.3094761 0.0016018823 5.891573e-02 2.003172e-01 10 79277181 79277325 145 + 1.655 1.593 -0.210
ENSG00000108175 E017 43.7701663 0.0011385205 1.108826e-02 6.274086e-02 10 79289775 79289889 115 + 1.687 1.593 -0.319
ENSG00000108175 E018 63.7967877 0.0111227000 6.031102e-02 2.035190e-01 10 79290959 79291176 218 + 1.839 1.757 -0.275
ENSG00000108175 E019 46.2145867 0.0008655774 8.258081e-01 9.113750e-01 10 79292158 79292356 199 + 1.616 1.675 0.201
ENSG00000108175 E020 10.9572714 0.0032023711 2.351287e-01 4.710591e-01 10 79293363 79293380 18 + 1.104 1.026 -0.285
ENSG00000108175 E021 51.1106798 0.0012609197 5.237505e-01 7.176400e-01 10 79293381 79293653 273 + 1.688 1.701 0.045
ENSG00000108175 E022 1.6300328 0.1898147215 6.851937e-01 8.260039e-01 10 79293654 79296470 2817 + 0.440 0.386 -0.293
ENSG00000108175 E023 40.9447260 0.0011357299 4.797964e-02 1.749484e-01 10 79296471 79296653 183 + 1.647 1.582 -0.221
ENSG00000108175 E024 0.1779838 0.0349795955 2.449460e-01   10 79296654 79296935 282 + 0.157 0.000 -12.234
ENSG00000108175 E025 37.4531388 0.0011183319 1.504627e-01 3.629653e-01 10 79297613 79297690 78 + 1.593 1.554 -0.132
ENSG00000108175 E026 56.4788872 0.0016024943 4.125210e-02 1.579856e-01 10 79298406 79298580 175 + 1.780 1.725 -0.189
ENSG00000108175 E027 59.8417719 0.0018313831 1.250517e-02 6.844796e-02 10 79299050 79299191 142 + 1.819 1.743 -0.257
ENSG00000108175 E028 73.1909914 0.0007984195 1.359166e-01 3.412111e-01 10 79300732 79300942 211 + 1.868 1.851 -0.056
ENSG00000108175 E029 53.6918210 0.0014347116 7.180036e-02 2.284041e-01 10 79302107 79302212 106 + 1.752 1.707 -0.153
ENSG00000108175 E030 70.2832784 0.0057485369 1.411779e-01 3.492644e-01 10 79304015 79304175 161 + 1.858 1.821 -0.126
ENSG00000108175 E031 46.7846542 0.0008754254 2.542976e-01 4.927542e-01 10 79305164 79305231 68 + 1.671 1.657 -0.048
ENSG00000108175 E032 55.8945123 0.0009084273 4.526989e-01 6.676800e-01 10 79305533 79305601 69 + 1.728 1.737 0.031
ENSG00000108175 E033 82.8504826 0.0005666095 6.513519e-01 8.044076e-01 10 79306100 79306344 245 + 1.888 1.917 0.098
ENSG00000108175 E034 58.3071236 0.0107086183 6.232175e-01 7.860407e-01 10 79307405 79307571 167 + 1.705 1.784 0.269
ENSG00000108175 E035 70.8045071 0.0014308101 8.494016e-01 9.245951e-01 10 79310924 79311184 261 + 1.814 1.853 0.130
ENSG00000108175 E036 1187.6927891 0.0026672223 6.729431e-09 3.277351e-07 10 79312642 79316519 3878 + 2.964 3.098 0.447