ENSG00000108061

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000369452 ENSG00000108061 HEK293_OSMI2_6hA HEK293_TMG_6hB SHOC2 protein_coding protein_coding 8.135756 1.122206 14.78049 0.3124277 0.3880724 3.707461 2.7231250 1.032708 4.147627 0.2683981 1.7327188 1.995425 0.5379000 0.9360333 0.28016667 -0.65586667 8.198815e-03 1.649589e-10 FALSE TRUE
ENST00000489783 ENSG00000108061 HEK293_OSMI2_6hA HEK293_TMG_6hB SHOC2 protein_coding processed_transcript 8.135756 1.122206 14.78049 0.3124277 0.3880724 3.707461 0.8770762 0.000000 1.343184 0.0000000 0.7993488 7.080214 0.0615500 0.0000000 0.09036667 0.09036667 7.206109e-01 1.649589e-10 FALSE FALSE
ENST00000692776 ENSG00000108061 HEK293_OSMI2_6hA HEK293_TMG_6hB SHOC2 protein_coding protein_coding 8.135756 1.122206 14.78049 0.3124277 0.3880724 3.707461 3.7777121 0.000000 8.357754 0.0000000 0.7138879 9.708697 0.2612125 0.0000000 0.56650000 0.56650000 1.649589e-10 1.649589e-10 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000108061 E001 0.0000000       10 110919367 110919441 75 +      
ENSG00000108061 E002 0.0000000       10 110919575 110919575 1 +      
ENSG00000108061 E003 0.3040503 0.0244411696 1.000000000   10 110919576 110919587 12 + 0.089 0.000 -12.917
ENSG00000108061 E004 0.3040503 0.0244411696 1.000000000   10 110919588 110919588 1 + 0.089 0.000 -12.913
ENSG00000108061 E005 0.3040503 0.0244411696 1.000000000   10 110919589 110919590 2 + 0.089 0.000 -12.913
ENSG00000108061 E006 0.3040503 0.0244411696 1.000000000   10 110919591 110919592 2 + 0.089 0.000 -12.913
ENSG00000108061 E007 0.3040503 0.0244411696 1.000000000   10 110919593 110919599 7 + 0.089 0.000 -12.913
ENSG00000108061 E008 0.4820342 0.0220049876 1.000000000   10 110919600 110919602 3 + 0.127 0.000 -13.499
ENSG00000108061 E009 0.6600180 0.0239385770 0.790344618   10 110919603 110919603 1 + 0.163 0.000 -13.916
ENSG00000108061 E010 0.6600180 0.0239385770 0.790344618   10 110919604 110919606 3 + 0.163 0.000 -13.916
ENSG00000108061 E011 8.1687015 0.0036614574 0.159988162 0.37678089 10 110919607 110919618 12 + 0.809 0.669 -0.569
ENSG00000108061 E012 22.1738006 0.0063632817 0.001942671 0.01668657 10 110919619 110919657 39 + 1.206 0.920 -1.041
ENSG00000108061 E013 0.1779838 0.1113083280 0.944581015   10 110920003 110920146 144 + 0.047 0.000 -11.920
ENSG00000108061 E014 0.6600180 0.0239385770 0.790344618   10 110920897 110920974 78 + 0.163 0.000 -13.916
ENSG00000108061 E015 0.0000000       10 110941377 110941474 98 +      
ENSG00000108061 E016 1.9223396 0.0105630560 0.800167023 0.89640390 10 110951608 110951790 183 + 0.329 0.453 0.694
ENSG00000108061 E017 0.9169527 0.0155269288 0.882764385   10 110951791 110951792 2 + 0.195 0.283 0.693
ENSG00000108061 E018 0.0000000       10 110955416 110955466 51 +      
ENSG00000108061 E019 219.8312392 0.0440045105 0.001232537 0.01166805 10 110964125 110965031 907 + 2.162 1.994 -0.563
ENSG00000108061 E020 40.8486923 0.0230622564 0.254653818 0.49314596 10 110965032 110965061 30 + 1.427 1.440 0.045
ENSG00000108061 E021 0.3088520 0.0306210336 0.188077025   10 110965062 110967161 2100 + 0.047 0.282 3.011
ENSG00000108061 E022 0.1779838 0.1113083280 0.944581015   10 110967162 110967278 117 + 0.047 0.000 -11.920
ENSG00000108061 E023 0.1723744 0.1601040808 0.062524863   10 110967279 110970194 2916 + 0.000 0.284 17.918
ENSG00000108061 E024 0.2027342 0.0362452587 0.057238252   10 110982796 110983439 644 + 0.000 0.283 17.915
ENSG00000108061 E025 77.4711151 0.0234079182 0.076839244 0.23846986 10 110985628 110985765 138 + 1.703 1.669 -0.113
ENSG00000108061 E026 0.0000000       10 110985766 110985922 157 +      
ENSG00000108061 E027 81.5289037 0.0227278689 0.005837750 0.03894155 10 111000415 111000545 131 + 1.734 1.604 -0.443
ENSG00000108061 E028 101.9059007 0.0350072588 0.048535577 0.17625749 10 111004606 111004794 189 + 1.824 1.754 -0.234
ENSG00000108061 E029 75.7395358 0.0159110713 0.287414794 0.52818001 10 111007531 111007653 123 + 1.684 1.732 0.160
ENSG00000108061 E030 61.7577029 0.0007675304 0.919560923 0.96200106 10 111009248 111009385 138 + 1.589 1.712 0.416
ENSG00000108061 E031 0.1779838 0.1113083280 0.944581015   10 111009386 111009712 327 + 0.047 0.000 -11.920
ENSG00000108061 E032 65.8597393 0.0366422925 0.168910462 0.38912189 10 111009713 111009830 118 + 1.602 1.821 0.744
ENSG00000108061 E033 0.8461841 0.0172671820 0.706811462   10 111009831 111010565 735 + 0.163 0.283 1.018
ENSG00000108061 E034 321.2067654 0.7179109505 0.157824158 0.37347136 10 111011610 111017307 5698 + 2.244 2.633 1.297