ENSG00000108021

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000328090 ENSG00000108021 HEK293_OSMI2_6hA HEK293_TMG_6hB TASOR2 protein_coding protein_coding 18.32259 11.8635 29.79291 3.156386 0.6868298 1.327709 0.9221657 0.70156149 1.12518492 0.37357726 0.163267474 0.673867 0.05409583 0.09486667 0.0378666667 -0.05700000 1.000000e+00 8.86283e-08 FALSE TRUE
ENST00000645567 ENSG00000108021 HEK293_OSMI2_6hA HEK293_TMG_6hB TASOR2 protein_coding protein_coding 18.32259 11.8635 29.79291 3.156386 0.6868298 1.327709 3.8612228 2.09328503 9.41809542 1.06216601 1.231405906 2.164322 0.18687083 0.13930000 0.3159666667 0.17666667 6.916303e-01 8.86283e-08 FALSE TRUE
ENST00000695737 ENSG00000108021 HEK293_OSMI2_6hA HEK293_TMG_6hB TASOR2 protein_coding protein_coding 18.32259 11.8635 29.79291 3.156386 0.6868298 1.327709 1.4186677 0.30591373 2.79840363 0.30591373 0.688095701 3.152148 0.05862500 0.05510000 0.0936000000 0.03850000 4.065105e-01 8.86283e-08 FALSE TRUE
ENST00000695832 ENSG00000108021 HEK293_OSMI2_6hA HEK293_TMG_6hB TASOR2 protein_coding protein_coding 18.32259 11.8635 29.79291 3.156386 0.6868298 1.327709 0.6625467 1.85104320 0.60308605 1.25024872 0.330719169 -1.601950 0.05032917 0.12360000 0.0207333333 -0.10286667 7.770467e-01 8.86283e-08 FALSE TRUE
ENST00000695833 ENSG00000108021 HEK293_OSMI2_6hA HEK293_TMG_6hB TASOR2 protein_coding protein_coding 18.32259 11.8635 29.79291 3.156386 0.6868298 1.327709 0.7983100 1.83594638 0.86908847 0.46395969 0.450704213 -1.070280 0.06792083 0.16156667 0.0285666667 -0.13300000 3.329701e-01 8.86283e-08 FALSE TRUE
ENST00000695837 ENSG00000108021 HEK293_OSMI2_6hA HEK293_TMG_6hB TASOR2 protein_coding nonsense_mediated_decay 18.32259 11.8635 29.79291 3.156386 0.6868298 1.327709 1.0610546 1.03582006 0.01695317 0.81022910 0.008731974 -5.278036 0.11850000 0.07093333 0.0005666667 -0.07036667 1.915426e-02 8.86283e-08 TRUE FALSE
MSTRG.3486.16 ENSG00000108021 HEK293_OSMI2_6hA HEK293_TMG_6hB TASOR2 protein_coding   18.32259 11.8635 29.79291 3.156386 0.6868298 1.327709 1.4544174 0.49905811 1.34576751 0.49905811 0.415719622 1.413208 0.06671667 0.03303333 0.0458000000 0.01276667 5.865351e-01 8.86283e-08 FALSE TRUE
MSTRG.3486.19 ENSG00000108021 HEK293_OSMI2_6hA HEK293_TMG_6hB TASOR2 protein_coding   18.32259 11.8635 29.79291 3.156386 0.6868298 1.327709 2.3939129 1.70307739 6.61342902 0.85292150 0.508680743 1.950988 0.10521250 0.11336667 0.2221666667 0.10880000 7.403518e-01 8.86283e-08 FALSE TRUE
MSTRG.3486.6 ENSG00000108021 HEK293_OSMI2_6hA HEK293_TMG_6hB TASOR2 protein_coding   18.32259 11.8635 29.79291 3.156386 0.6868298 1.327709 1.6418399 0.04521755 2.80626095 0.04521755 0.152180196 5.672510 0.06310833 0.00300000 0.0945333333 0.09153333 8.862830e-08 8.86283e-08 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000108021 E001 0.3559677 0.5601622128 7.200612e-01   10 5684589 5684653 65 + 0.159 0.000 -10.295
ENSG00000108021 E002 0.3559677 0.5601622128 7.200612e-01   10 5684654 5684730 77 + 0.159 0.000 -12.035
ENSG00000108021 E003 0.5339515 0.9093532864 6.924445e-01   10 5684731 5684734 4 + 0.225 0.000 -12.469
ENSG00000108021 E004 2.3926072 0.0086897084 3.218398e-01 5.613034e-01 10 5684735 5684826 92 + 0.552 0.391 -0.815
ENSG00000108021 E005 4.5380057 0.0509723377 5.334332e-01 7.245253e-01 10 5684827 5684837 11 + 0.739 0.646 -0.390
ENSG00000108021 E006 4.8302895 0.0125968519 5.775322e-01 7.554767e-01 10 5684838 5684847 10 + 0.756 0.690 -0.272
ENSG00000108021 E007 6.8355737 0.0051608905 8.962908e-01 9.499341e-01 10 5684848 5684860 13 + 0.857 0.893 0.135
ENSG00000108021 E008 11.1030219 0.0030735459 8.299119e-01 9.137259e-01 10 5684861 5684882 22 + 1.044 1.086 0.153
ENSG00000108021 E009 13.1961202 0.0031964045 3.951083e-01 6.244742e-01 10 5684883 5684936 54 + 1.091 1.192 0.362
ENSG00000108021 E010 10.8033407 0.0298117455 6.114581e-01 7.778757e-01 10 5684937 5684941 5 + 1.020 1.098 0.284
ENSG00000108021 E011 10.0438099 0.0054483379 9.730146e-01 9.884742e-01 10 5684942 5684947 6 + 1.009 1.030 0.078
ENSG00000108021 E012 9.8894789 0.0052864925 7.792759e-01 8.843350e-01 10 5684948 5684964 17 + 0.999 1.049 0.181
ENSG00000108021 E013 46.6484835 0.0014939431 1.200437e-02 6.645936e-02 10 5684965 5685175 211 + 1.686 1.556 -0.441
ENSG00000108021 E014 0.3393995 0.0250677655 5.470763e-01   10 5692816 5692918 103 + 0.155 0.000 -13.342
ENSG00000108021 E015 0.0000000       10 5699448 5699492 45 +      
ENSG00000108021 E016 1.2835031 0.5337817267 6.143982e-01   10 5699493 5699737 245 + 0.397 0.174 -1.602
ENSG00000108021 E017 36.0026949 0.0321977048 1.576364e-02 8.096505e-02 10 5709530 5709625 96 + 1.605 1.357 -0.854
ENSG00000108021 E018 29.7961346 0.1037944946 1.140600e-01 3.058487e-01 10 5709626 5709663 38 + 1.534 1.230 -1.054
ENSG00000108021 E019 46.9826338 0.9669971136 9.499988e-01 9.770806e-01 10 5712394 5712539 146 + 1.704 1.490 -0.731
ENSG00000108021 E020 63.6856714 0.1952025743 4.168441e-01 6.412635e-01 10 5712823 5712918 96 + 1.848 1.569 -0.946
ENSG00000108021 E021 45.0157168 0.9724705955 9.792524e-01 9.913932e-01 10 5714135 5714207 73 + 1.694 1.445 -0.848
ENSG00000108021 E022 1.3905307 0.5495343442 9.108075e-01 9.575334e-01 10 5714208 5714574 367 + 0.363 0.309 -0.333
ENSG00000108021 E023 44.9362637 0.0777885007 1.635964e-01 3.820969e-01 10 5717659 5717750 92 + 1.693 1.453 -0.819
ENSG00000108021 E024 16.3241608 0.1025656269 2.331999e-01 4.688486e-01 10 5720260 5720397 138 + 1.266 1.045 -0.789
ENSG00000108021 E025 104.7779213 0.0181689953 3.200525e-06 7.846437e-05 10 5720544 5720668 125 + 2.076 1.733 -1.154
ENSG00000108021 E026 69.0339937 0.0006152319 1.012398e-13 1.258628e-11 10 5720755 5720774 20 + 1.903 1.532 -1.255
ENSG00000108021 E027 106.1668750 0.0004390866 2.535272e-16 4.575425e-14 10 5720871 5720970 100 + 2.077 1.755 -1.083
ENSG00000108021 E028 117.0796877 0.0003478739 4.509861e-14 6.002179e-12 10 5723677 5723777 101 + 2.109 1.836 -0.917
ENSG00000108021 E029 100.1915484 0.0004471453 9.519356e-12 8.206119e-10 10 5724430 5724533 104 + 2.042 1.777 -0.893
ENSG00000108021 E030 1.1089159 0.0192084747 4.713477e-02   10 5726826 5726884 59 + 0.397 0.000 -15.257
ENSG00000108021 E031 100.7602053 0.0066394803 1.834324e-06 4.832616e-05 10 5726885 5726957 73 + 2.043 1.791 -0.847
ENSG00000108021 E032 93.3122500 0.0140040903 2.332724e-05 4.355199e-04 10 5727061 5727123 63 + 2.017 1.729 -0.969
ENSG00000108021 E033 148.9987610 0.0074058762 1.440931e-06 3.907126e-05 10 5730487 5730661 175 + 2.210 1.959 -0.841
ENSG00000108021 E034 275.0614000 0.0010169050 7.168834e-17 1.396139e-14 10 5730662 5731203 542 + 2.469 2.245 -0.748
ENSG00000108021 E035 112.9953899 0.0005186578 1.060432e-04 1.571429e-03 10 5735304 5735546 243 + 2.061 1.933 -0.430
ENSG00000108021 E036 54.5560482 0.0007575457 4.382443e-01 6.574264e-01 10 5739618 5739623 6 + 1.724 1.704 -0.067
ENSG00000108021 E037 209.4485266 0.0002528134 3.854612e-09 1.981240e-07 10 5739624 5739902 279 + 2.334 2.191 -0.480
ENSG00000108021 E038 202.7815490 0.0023456771 9.485094e-07 2.711763e-05 10 5739903 5740154 252 + 2.323 2.157 -0.555
ENSG00000108021 E039 229.1946249 0.0002323944 5.494515e-09 2.733944e-07 10 5740155 5740497 343 + 2.369 2.235 -0.449
ENSG00000108021 E040 291.6989699 0.0002026989 7.088501e-09 3.438419e-07 10 5742097 5742526 430 + 2.468 2.352 -0.384
ENSG00000108021 E041 234.5814690 0.0008345842 7.696440e-02 2.387143e-01 10 5746179 5746464 286 + 2.350 2.318 -0.107
ENSG00000108021 E042 1803.9408951 0.0002343882 8.820750e-01 9.424016e-01 10 5746465 5749245 2781 + 3.221 3.236 0.052
ENSG00000108021 E043 530.2717365 0.0009761031 8.860014e-07 2.557162e-05 10 5749246 5749878 633 + 2.652 2.776 0.413
ENSG00000108021 E044 242.0522339 0.0002624818 1.269625e-05 2.580630e-04 10 5749879 5750027 149 + 2.312 2.439 0.422
ENSG00000108021 E045 0.0000000       10 5753408 5753432 25 +      
ENSG00000108021 E046 0.1779838 0.0417732904 1.000000e+00   10 5754461 5754532 72 + 0.084 0.000 -12.101
ENSG00000108021 E047 252.9869917 0.0010886305 5.915532e-10 3.590398e-08 10 5756613 5756738 126 + 2.305 2.491 0.620
ENSG00000108021 E048 304.0314199 0.0037243159 6.884335e-08 2.657691e-06 10 5757520 5757673 154 + 2.374 2.585 0.703
ENSG00000108021 E049 185.8889029 0.0009271670 1.361623e-06 3.717005e-05 10 5758887 5758928 42 + 2.182 2.346 0.549
ENSG00000108021 E050 200.3546966 0.0003798725 4.011989e-12 3.725973e-10 10 5758929 5758992 64 + 2.198 2.403 0.683
ENSG00000108021 E051 8.4660635 0.1736098384 2.186052e-01 4.517698e-01 10 5760840 5761289 450 + 0.842 1.104 0.976
ENSG00000108021 E052 281.4371008 0.0015300123 4.040823e-16 7.133313e-14 10 5761290 5761471 182 + 2.325 2.575 0.831
ENSG00000108021 E053 2.1781359 0.0879391160 4.479618e-02 1.671226e-01 10 5761472 5761801 330 + 0.317 0.693 1.871
ENSG00000108021 E054 206.4208490 0.0066400249 1.032791e-07 3.817012e-06 10 5762532 5762646 115 + 2.179 2.453 0.912
ENSG00000108021 E055 5.1186510 0.3008875426 2.751587e-01 5.151790e-01 10 5762647 5763028 382 + 0.656 0.919 1.047
ENSG00000108021 E056 376.9615293 0.0142765395 6.273261e-08 2.444010e-06 10 5763029 5764899 1871 + 2.405 2.750 1.149