ENSG00000108010

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000331244 ENSG00000108010 HEK293_OSMI2_6hA HEK293_TMG_6hB GLRX3 protein_coding protein_coding 105.7217 47.05604 157.1208 6.731713 5.871937 1.739207 93.065475 38.955658 144.119404 5.770169 5.3571132 1.8870896 0.861900 0.8266667 0.9172667 0.09060000 3.853113e-06 3.853113e-06 FALSE  
MSTRG.4820.3 ENSG00000108010 HEK293_OSMI2_6hA HEK293_TMG_6hB GLRX3 protein_coding   105.7217 47.05604 157.1208 6.731713 5.871937 1.739207 9.167476 5.928423 9.992893 1.346232 0.4593831 0.7522656 0.097025 0.1226333 0.0636000 -0.05903333 1.700987e-02 3.853113e-06 TRUE  
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000108010 E001 0.0000000       10 130136227 130136351 125 +      
ENSG00000108010 E002 3.4512285 7.182358e-03 6.135565e-03 4.039701e-02 10 130136352 130136390 39 + 0.448 0.859 1.784
ENSG00000108010 E003 10.2361330 3.059556e-03 4.068194e-01 6.336133e-01 10 130136391 130136398 8 + 0.984 1.075 0.332
ENSG00000108010 E004 273.5316452 6.159847e-04 2.284176e-01 4.633941e-01 10 130136399 130136512 114 + 2.386 2.417 0.103
ENSG00000108010 E005 471.9124142 2.013029e-03 4.825600e-01 6.887637e-01 10 130145211 130145319 109 + 2.626 2.645 0.063
ENSG00000108010 E006 0.1723744 4.070667e-02 1.822725e-01   10 130159746 130159834 89 + 0.000 0.181 9.900
ENSG00000108010 E007 475.9637865 1.628255e-03 3.301449e-01 5.690960e-01 10 130159995 130160069 75 + 2.641 2.616 -0.085
ENSG00000108010 E008 924.4990744 2.710245e-04 5.182278e-01 7.138128e-01 10 130160796 130160997 202 + 2.926 2.916 -0.031
ENSG00000108010 E009 976.9996187 5.484944e-04 1.281561e-01 3.288735e-01 10 130166507 130166679 173 + 2.953 2.930 -0.077
ENSG00000108010 E010 734.4738272 1.472763e-03 6.227418e-03 4.084974e-02 10 130166919 130166980 62 + 2.838 2.778 -0.200
ENSG00000108010 E011 741.1388692 9.705506e-05 4.344751e-03 3.107083e-02 10 130169433 130169490 58 + 2.838 2.797 -0.137
ENSG00000108010 E012 723.7915721 2.307420e-04 7.279479e-02 2.303936e-01 10 130171584 130171636 53 + 2.823 2.795 -0.095
ENSG00000108010 E013 622.8152899 8.589943e-04 4.018647e-01 6.299289e-01 10 130174867 130174906 40 + 2.755 2.736 -0.064
ENSG00000108010 E014 793.0837531 1.744786e-04 7.692873e-01 8.782287e-01 10 130174997 130175089 93 + 2.855 2.858 0.013
ENSG00000108010 E015 474.2605931 1.855371e-04 9.498338e-01 9.769889e-01 10 130179342 130179373 32 + 2.633 2.632 -0.005
ENSG00000108010 E016 479.4527368 1.231697e-04 1.212596e-01 3.178568e-01 10 130179374 130179420 47 + 2.630 2.657 0.091
ENSG00000108010 E017 261.1815839 2.178100e-04 4.864071e-01 6.915246e-01 10 130179421 130179672 252 + 2.380 2.363 -0.058
ENSG00000108010 E018 111.6391628 4.061876e-04 3.780499e-15 5.875647e-13 10 130180113 130180184 72 + 1.909 2.184 0.922
ENSG00000108010 E019 92.3270854 4.934529e-04 8.822813e-20 2.506720e-17 10 130180185 130180321 137 + 1.796 2.142 1.165
ENSG00000108010 E020 74.4275720 4.380233e-02 2.653322e-04 3.378787e-03 10 130180322 130182881 2560 + 1.673 2.082 1.377
ENSG00000108010 E021 1.1140774 1.537876e-02 4.037877e-01   10 130183281 130183284 4 + 0.256 0.407 0.954
ENSG00000108010 E022 6.5563658 2.138511e-02 5.080184e-03 3.505046e-02 10 130183285 130183644 360 + 0.700 1.074 1.437
ENSG00000108010 E023 5.3453483 7.787544e-02 5.715021e-02 1.963677e-01 10 130183868 130184521 654 + 0.643 0.972 1.302