ENSG00000107863

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000376410 ENSG00000107863 HEK293_OSMI2_6hA HEK293_TMG_6hB ARHGAP21 protein_coding protein_coding 12.44423 10.32303 19.67579 1.282766 0.8277111 0.9298916 6.7519647 3.69024184 11.9505286 0.99321000 0.5624590 1.692590 0.4712000 0.345233333 0.60940000 0.26416667 5.069025e-02 7.385555e-05 FALSE TRUE
ENST00000476067 ENSG00000107863 HEK293_OSMI2_6hA HEK293_TMG_6hB ARHGAP21 protein_coding retained_intron 12.44423 10.32303 19.67579 1.282766 0.8277111 0.9298916 0.1180497 0.71641373 0.2279836 0.71641373 0.2279836 -1.609929 0.0128500 0.090500000 0.01230000 -0.07820000 9.832785e-01 7.385555e-05   FALSE
ENST00000638156 ENSG00000107863 HEK293_OSMI2_6hA HEK293_TMG_6hB ARHGAP21 protein_coding nonsense_mediated_decay 12.44423 10.32303 19.67579 1.282766 0.8277111 0.9298916 2.1898411 4.17012745 0.6580807 0.90382545 0.3712351 -2.645453 0.2730375 0.393666667 0.03396667 -0.35970000 7.385555e-05 7.385555e-05 FALSE TRUE
ENST00000680286 ENSG00000107863 HEK293_OSMI2_6hA HEK293_TMG_6hB ARHGAP21 protein_coding protein_coding 12.44423 10.32303 19.67579 1.282766 0.8277111 0.9298916 0.1975934 0.64785224 0.0000000 0.64785224 0.0000000 -6.039692 0.0277125 0.060233333 0.00000000 -0.06023333 8.442682e-01 7.385555e-05 FALSE TRUE
MSTRG.3670.13 ENSG00000107863 HEK293_OSMI2_6hA HEK293_TMG_6hB ARHGAP21 protein_coding   12.44423 10.32303 19.67579 1.282766 0.8277111 0.9298916 0.8157399 0.09369619 2.7867223 0.09369619 0.9104646 4.753302 0.0454000 0.007633333 0.13890000 0.13126667 3.129297e-02 7.385555e-05 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000107863 E001 0.0000000       10 24583609 24583613 5 -      
ENSG00000107863 E002 1.4181277 0.0136968632 8.320433e-01 0.9150137475 10 24583614 24583616 3 - 0.368 0.381 0.077
ENSG00000107863 E003 4.6587706 0.1422997747 4.742432e-02 0.1735649574 10 24583617 24583630 14 - 0.503 0.987 1.995
ENSG00000107863 E004 541.6621123 1.7521608160 3.597450e-01 0.5955924113 10 24583631 24585701 2071 - 2.527 2.937 1.366
ENSG00000107863 E005 58.7665277 0.7646457922 2.796510e-01 0.5197505721 10 24585702 24585716 15 - 1.617 1.938 1.084
ENSG00000107863 E006 113.3371640 1.2393739242 3.820973e-01 0.6139387047 10 24585717 24585919 203 - 1.900 2.217 1.065
ENSG00000107863 E007 35.1726154 0.6216560633 3.261991e-01 0.5653759877 10 24585920 24585929 10 - 1.429 1.689 0.888
ENSG00000107863 E008 70.3596383 0.8345551689 3.350363e-01 0.5736004121 10 24585930 24586032 103 - 1.714 1.994 0.943
ENSG00000107863 E009 57.9716350 0.7731016030 3.259897e-01 0.5652322634 10 24586033 24586106 74 - 1.633 1.909 0.935
ENSG00000107863 E010 49.3148253 0.0463628556 7.195528e-01 0.8479457517 10 24589271 24589302 32 - 1.645 1.737 0.313
ENSG00000107863 E011 6.7317290 0.1407712092 4.149598e-01 0.6397827437 10 24589303 24590042 740 - 0.888 0.795 -0.361
ENSG00000107863 E012 2.3627247 0.1715752942 6.458988e-01 0.8007627348 10 24590206 24590453 248 - 0.512 0.465 -0.232
ENSG00000107863 E013 1.8130289 0.0877197852 5.638836e-02 0.1945400883 10 24590454 24590479 26 - 0.510 0.167 -2.253
ENSG00000107863 E014 2.4096527 0.1534404080 6.441252e-01 0.7995879895 10 24590480 24590550 71 - 0.512 0.466 -0.229
ENSG00000107863 E015 86.7457620 0.0068060104 7.119826e-01 0.8430818985 10 24591225 24591330 106 - 1.897 1.958 0.204
ENSG00000107863 E016 3.4659296 0.0555225635 2.026393e-01 0.4328655305 10 24591345 24591641 297 - 0.680 0.521 -0.704
ENSG00000107863 E017 60.0378978 0.0006862631 4.325569e-02 0.1632184735 10 24591642 24591683 42 - 1.764 1.757 -0.023
ENSG00000107863 E018 93.9457238 0.0005869714 4.478812e-01 0.6641390150 10 24591887 24592012 126 - 1.933 1.995 0.208
ENSG00000107863 E019 39.4140022 0.0013258740 6.137310e-01 0.7793813907 10 24594950 24594969 20 - 1.539 1.658 0.406
ENSG00000107863 E020 57.9403993 0.0146552078 4.905649e-01 0.6943706037 10 24594970 24595000 31 - 1.692 1.839 0.496
ENSG00000107863 E021 64.2775780 0.0104577273 8.869323e-01 0.9450645321 10 24595001 24595039 39 - 1.753 1.861 0.365
ENSG00000107863 E022 81.0228597 0.0102627159 8.297032e-01 0.9135998792 10 24595117 24595190 74 - 1.859 1.947 0.299
ENSG00000107863 E023 84.9035870 0.0176120179 9.780997e-01 0.9908068783 10 24595717 24595795 79 - 1.871 1.973 0.344
ENSG00000107863 E024 95.3081931 0.0061089257 1.113059e-01 0.3011501809 10 24595888 24596043 156 - 1.955 1.966 0.038
ENSG00000107863 E025 11.9500404 0.1338217083 9.290996e-02 0.2691441452 10 24596044 24596739 696 - 1.155 0.900 -0.937
ENSG00000107863 E026 70.1421386 0.0031619817 9.836440e-01 0.9936552200 10 24596740 24596821 82 - 1.799 1.889 0.305
ENSG00000107863 E027 52.3928487 0.0009151098 9.220803e-01 0.9633192796 10 24596822 24596840 19 - 1.674 1.760 0.292
ENSG00000107863 E028 65.7423839 0.0006493301 9.327634e-01 0.9685126169 10 24596841 24596882 42 - 1.773 1.861 0.297
ENSG00000107863 E029 54.7403552 0.0006646980 7.226269e-01 0.8496884609 10 24597447 24597468 22 - 1.686 1.794 0.366
ENSG00000107863 E030 84.9845448 0.0028168102 3.412721e-01 0.5792225306 10 24597469 24597583 115 - 1.897 1.950 0.180
ENSG00000107863 E031 63.6418996 0.0009733681 7.134961e-03 0.0452558649 10 24597945 24598009 65 - 1.802 1.767 -0.120
ENSG00000107863 E032 71.4262492 0.0034059205 2.637628e-02 0.1164028898 10 24600646 24600788 143 - 1.845 1.826 -0.065
ENSG00000107863 E033 73.2610780 0.0064031064 2.195441e-01 0.4528561344 10 24600789 24600930 142 - 1.837 1.862 0.084
ENSG00000107863 E034 92.4260896 0.0133303041 9.338067e-02 0.2700276822 10 24601978 24602103 126 - 1.950 1.929 -0.071
ENSG00000107863 E035 58.3698751 0.0207008987 8.003010e-03 0.0493229979 10 24604312 24604348 37 - 1.787 1.652 -0.457
ENSG00000107863 E036 0.0000000       10 24605767 24605774 8 -      
ENSG00000107863 E037 0.3393995 0.0262174574 4.004125e-01   10 24607444 24607498 55 - 0.160 0.000 -11.327
ENSG00000107863 E038 98.6780459 0.0199738258 6.737191e-02 0.2191777932 10 24607499 24607601 103 - 1.990 1.934 -0.189
ENSG00000107863 E039 103.5619122 0.0137603068 2.509381e-01 0.4890020269 10 24607745 24607903 159 - 1.989 2.005 0.055
ENSG00000107863 E040 1.8091165 0.0110281568 1.246600e-03 0.0117690294 10 24609430 24609453 24 - 0.160 0.753 3.393
ENSG00000107863 E041 84.9964564 0.0066620226 3.496141e-01 0.5869213790 10 24619473 24619681 209 - 1.894 1.941 0.159
ENSG00000107863 E042 139.9239945 0.0217335993 1.291561e-01 0.3304430995 10 24619682 24620149 468 - 2.126 2.113 -0.042
ENSG00000107863 E043 92.6740383 0.0278230725 3.577069e-02 0.1436333844 10 24620150 24620439 290 - 1.973 1.878 -0.319
ENSG00000107863 E044 95.3099751 0.0029062264 6.428409e-06 0.0001432102 10 24620440 24620878 439 - 1.995 1.881 -0.386
ENSG00000107863 E045 122.0542516 0.0102512244 1.296792e-04 0.0018568721 10 24620879 24621369 491 - 2.104 1.971 -0.444
ENSG00000107863 E046 0.4654660 0.0225897119 2.125401e-01   10 24622733 24622762 30 - 0.222 0.000 -11.910
ENSG00000107863 E047 0.3228314 0.3193992474 5.004362e-01   10 24622763 24622842 80 - 0.160 0.000 -11.331
ENSG00000107863 E048 0.3032425 0.0274424043 9.247436e-02   10 24629014 24629523 510 - 0.000 0.287 13.438
ENSG00000107863 E049 0.8344176 0.0198433823 8.951151e-01   10 24629524 24629862 339 - 0.222 0.287 0.488
ENSG00000107863 E050 0.4702677 0.0215521277 9.388869e-01   10 24629863 24629995 133 - 0.160 0.167 0.071
ENSG00000107863 E051 31.6623642 0.0013532789 7.699466e-04 0.0080266820 10 24629996 24630050 55 - 1.533 1.395 -0.474
ENSG00000107863 E052 43.7075168 0.0012282499 6.250930e-04 0.0067969763 10 24633402 24633480 79 - 1.660 1.552 -0.368
ENSG00000107863 E053 52.8243730 0.0162733962 6.476436e-03 0.0420784967 10 24635011 24635103 93 - 1.744 1.612 -0.447
ENSG00000107863 E054 35.2481336 0.0190827221 1.207339e-04 0.0017463079 10 24666985 24667009 25 - 1.606 1.332 -0.945
ENSG00000107863 E055 55.3655342 0.0262033153 4.758447e-04 0.0054575117 10 24670218 24670338 121 - 1.791 1.543 -0.843
ENSG00000107863 E056 36.4655140 0.0115008736 1.747663e-03 0.0153532329 10 24670339 24670397 59 - 1.596 1.433 -0.561
ENSG00000107863 E057 0.0000000       10 24706512 24706630 119 -      
ENSG00000107863 E058 0.0000000       10 24714297 24714378 82 -      
ENSG00000107863 E059 54.9159289 0.0300725794 2.023253e-03 0.0172141745 10 24721837 24722011 175 - 1.781 1.581 -0.679
ENSG00000107863 E060 53.3345475 0.0298100791 9.976484e-03 0.0580635548 10 24722012 24722225 214 - 1.755 1.613 -0.481
ENSG00000107863 E061 19.2627104 0.0243573756 6.199110e-02 0.2072467634 10 24722226 24722279 54 - 1.319 1.210 -0.385
ENSG00000107863 E062 3.2485823 0.0550699821 2.910259e-01 0.5316062818 10 24722486 24722760 275 - 0.640 0.522 -0.530
ENSG00000107863 E063 1.3073442 0.2985883343 9.493445e-01   10 24723157 24723247 91 - 0.323 0.442 0.677
ENSG00000107863 E064 11.3601436 0.0121019866 1.366373e-01 0.3423553686 10 24723562 24724088 527 - 1.099 1.014 -0.312